Results 91 to 100 of about 262,486 (214)
Cardiomyocyte mitochondria as targets of humoral factors released by remote ischemic preconditioning
, 2016 Introduction: Remote ischemic preconditioning (RIPC) reduces myocardial infarct size, and protection can be transferred with plasma to other individuals, even across species.
Gerd Heusch +5 more
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Experimental Physiology, EarlyView.Abstract Renal ischaemia–reperfusion (I/R) injury leads to acute tubular necrosis and renal failure, triggering pathological mechanisms including inflammation, reactive oxygen species generation, apoptosis and mitochondrial dysfunction. The mitochondrial peptide humanin (HN), known to possess anti‐apoptotic and anti‐inflammatory properties, has been ...
Leyla Abueid +4 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti +2 more
wiley +1 more source
The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity
The Journal of Physiology, EarlyView.Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas +5 more
wiley +1 more source
Radiation‐Induced Skin Injury in Cancer Radiotherapy: From Mechanisms to Management
Advanced Oncology, Volume 1, Issue 1, December 2026.Radiation‐induced skin injuries (RISI) remain a significant challenge faced by cancer patients receiving radiotherapy (RT). This perspective article examines the pathophysiology of RISI and evaluates the currently existing and emerging therapeutic strategies, including stem cell‐derived exosomes and advanced hydrogels.
Zeynep Meral Toutoungi +3 more
wiley +1 more source
Ischemic preconditioning: Protection against myocardial necrosis and apoptosis
, 2007 Efstathios K Iliodromitis1, Antigone Lazou2, Dimitrios Th Kremastinos112nd University Department of Cardiology, Medical School, University of Athens, Greece; 2Lab of Animal Physiology, School of Biology, Aristotle University of Thessaloniki ...
Antigone Lazou +2 more
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Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2396-2411, November 2026.ABSTRACT Purpose To develop a data‐efficient strategy for accelerated MRI reconstruction with Diffusion Probabilistic Generative Models (DPMs) that enables faster scan times in clinical stroke MRI when only limited fully‐sampled data are available. Methods Our simple training strategy first pre‐trains a DPM on a large, diverse collection of publicly ...
Yamin Arefeen +4 more
wiley +1 more source
Disease Models & Mechanisms, 2014 Following a period of ischemia (local restriction of blood supply to a tissue), the restoration of blood supply to the affected area causes significant tissue damage.
Kieran McCafferty +3 more
doaj +1 more source
Gq Signaling in Microglia Triggers Interferon Responses and Improves Outcome After Ischemic Stroke
Glia, Volume 74, Issue 10, October 2026.Chemogenetic activation of Gq signaling in microglia ahead of ischemic stroke reduces infarct size in mice. Seven days after stroke, Gq‐primed microglia in the penumbra show enhanced interferon responses, altered branching patterns, and reduced phagocytosis.
Lynn Bitar +8 more
wiley +1 more source
Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm [PDF]
, 2006 Background: Hypoxic cell death follows interruption of blood supply to tissues. Although successful restoration of blood flow is mandatory for salvage of ischemic tissues, reperfusion can paradoxically place tissues at risk of further injury.
MacAllister, R.J. +4 more
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