Results 71 to 80 of about 50,311 (298)

Sequential Wnt Agonist then Antagonist Treatment Accelerates Tissue Repair and Minimizes Fibrosis [PDF]

, 2019
Tissue fibrosis compromises organ function and occurs as a potential long-term outcome in response to acute tissue injuries. Currently, lack of mechanistic understanding prevents effective prevention and treatment of the progression from acute injury to ...
Fu, Haiyan, Huang, Sui, Liu, Youhua, Tian, Xiao-Jun, Wang, Xiaojie, Xing, Jianhua, Zhang, Rong, Zhou, Dong   +7 more
core   +2 more sources

Modified Sleep Apnea Severity Index and Cardiovascular Risk in CPAP‐Intolerant OSA Patients

The Laryngoscope, EarlyView.
The modified sleep apnea severity index (mSASI) combines patient anatomy, weight, sleep study metrics, and symptoms into a composite OSA index ranging from 1 (least severe) to 3 (most severe). Our study found that mSASI correlated better with baseline cardiovascular risk measured by the 5‐year Framingham Risk Score compared to the AHI.
Praneet C. Kaki, Jennifer A. Goldfarb, Melissa Xu, Daniel J. Campbell, Nicole Molin, Erin Creighton, Thomas M. Kaffenberger, Maurits Boon, Colin Huntley   +8 more
wiley   +1 more source

Association between clinical presentations before myocardial infarction and coronary mortality: a prospective population-based study using linked electronic records. [PDF]

, 2014
BACKGROUND: Ischaemia in different arterial territories before acute myocardial infarction (AMI) may influence post-AMI outcomes. No studies have evaluated prospectively collected information on ischaemia and its effect on short- and long-term coronary ...
Bhaskaran, Krishnan, Denaxas, Spiros, Hemingway, Harry, Herrett, Emily, Smeeth, Liam, Timmis, Adam   +5 more
core   +1 more source

Non-ischemic myocardial preconditioning

Molecular and Cellular Biochemistry, 1998
The reduction of infarct size produced by brief ischemic episodes prior to a sustained occlusion of a coronary artery, called ischemic preconditioning, is a well known phenomenon that occurs in several species, but its mechanism is still under investigation.
Domenech Lira, Raúl, Macho Fisher, Pilar   +1 more
openaire   +3 more sources

Remote ischemic preconditioning

Journal of Cardiovascular Medicine, 2013
Since cardiac surgery began, surgeons have aimed to find methods of minimizing myocardial injury resulting from ischemia and reperfusion. The concept of somehow conditioning the heart in order to attenuate ischemia and reperfusion-related injury has evolved in cardiovascular research over decades, from ischemic preconditioning and postconditioning to ...
Thielmann, Matthias Klaus, Wendt, Daniel, Tsagakis, Konstantinos, Price, Vivien, Dohle, Daniel-Sebastian, Pasa, Susanne, Kottenberg, Eva   +6 more
openaire   +4 more sources

Integrity of Cerebellar Fastigial Nucleus Intrinsic Neurons Is Critical for the Global Ischemic Preconditioning

Brain Sciences, 2017
Excitation of intrinsic neurons of cerebellar fastigial nucleus (FN) renders brain tolerant to local and global ischemia. This effect reaches a maximum 72 h after the stimulation and lasts over 10 days.
Eugene V. Golanov, Angelique S. Regnier-Golanov, Gavin W. Britz   +2 more
doaj   +1 more source

Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs [PDF]

, 1999
Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
David W. Busija, Ferenc Bari, Ferenc Domoki, James V. Perciaccante, Roland Veltkamp   +4 more
core   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Preconditioning in globally ischemic isolated rat hearts: effect on function and metabolic indices of myocardial damage [PDF]

, 1996
We assessed the effects of ischemic preconditioning on heart recovery and metabolic indices of damage following global ischemia and reperfusion, in relationship to post-ischemic lactate release.
Arad, M., Huizer, T. (Tom), Jong, J.W. (Jan Willem) de, Jonge, R. (Robert) de, Rabinowitz, B.   +4 more
core   +1 more source

Ischemic preconditioning and clinical scenarios [PDF]

Current Opinion in Neurology, 2013
Ischemic preconditioning (IPC) is gaining attention as a novel neuroprotective therapy and could provide an improved mechanistic understanding of tolerance to cerebral ischemia. The purpose of this article is to review the recent work in the field of IPC and its applications to clinical scenarios.The cellular signaling pathways that are activated ...
Srinivasan V, Narayanan, Kunjan R, Dave, Miguel A, Perez-Pinzon   +2 more
openaire   +2 more sources