Results 51 to 60 of about 50,311 (298)

Preconditioning as a method of neuroprotection in a model of brain infarct

Анналы клинической и экспериментальной неврологии, 2017
Preconditioning of ischemic and hypoxic type was investigated as a method of protecting brain against acute ischemic injury. The preconditioning methods were applied to experimental rats 24 h before the time when local brain infarct was done by middle ...
R. M. Khudoerkov, N. S. Samojlenkova, S. A. Gavrilova, Yu. A. Pirogov, V. B. Koshelev   +4 more
doaj   +1 more source

Sevoflurane preconditioning induces tolerance to brain ischemia partially via inhibiting thioredoxin-1 nitration

BMC Anesthesiology, 2018
Background Sevoflurane preconditioning induces brain ischemic tolerance, but the mechanism remains poorly elucidated. Nitration is an important form of post-translational modification in pathological signaling.
Shiquan Wang, Yuheng Li, Jinlong Wei, Pei Li, Qianzi Yang   +4 more
doaj   +1 more source

EFEITOS DO PRÉ-CONDICIONAMENTO HEPÁTICO EM RATOS CIRRÓTICOS, SUBMETIDOS À ISQUEMIA E REPERFUSÃO HEPÁTICA RESULTADOS PRELIMINARES PRECONDITIONING WITH ISCHEMIC-REPERFUSION FOR PROTECTION FROM ISCHEMIC INJURY IN RAT LIVER CIRRHOSIS PRELIMINARY RESULT

Acta Cirúrgica Brasileira, 2001
Baseando-se nos efeitos estimuladores do metabolismo energético pelo pré-condicionamento isquêmico (PCI) no tecido hepático, estudou-se dois grupos de ratos cirróticos submetidos a isquemia de 20 min e reperfusão de 120 min, após o PCI ou não ...
E.G. Pacheco, F.S. Ramalho, L.N.Z. Ramalho, S. Zucoloto, O. Castro e Silva Jr., A.F. Oliveira   +5 more
doaj   +1 more source

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection [PDF]

, 2004
Background - Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial reactive oxygen species (ROS) signaling.
Duchen, M, Hausenloy, D, Wynne, A, Yellon, D   +3 more
core   +1 more source

Remote Ischemic Preconditioning [PDF]

Circulation, 2011
Circulatory arrest and stroke are among the leading causes of death and disability worldwide, and they are difficult to treat. Only a limited number of therapeutic approaches have reached the bedside (eg, hypothermia and recombinant tissue plasminogen activator)1 and, unfortunately, relatively few patients are eligible.
Michael A. Moskowitz, Christian Waeber
openaire   +1 more source

Cardioprotective effects of exogenous and endogenous hydrocortisone in the rabbit model of ischemia-reperfusion Efectos cardioprotectores de la hidrocortisona exógena y endógena en el modelo isquemia-reperfusión de conejo [PDF]

, 2010
Reducing the infarct size in acute myocardial infarction is one of the most important goals driving new drug research and development. During the last two decades, many clinical studies have found cardioprotective effects of corticosteroids, but their ...
Davarian, A., Khori, V., Nayebpour, M.
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Functional protection by acute phase proteins alpha(1)-acid glycoprotein and alpha(1)-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation. [PDF]

, 2000
BACKGROUND: Ischemia followed by reperfusion (I/R) causes apoptosis, inflammation, and tissue damage leading to organ malfunction. Ischemic preconditioning can protect against such injury.
BUURMAN, WA, DAEMEN, M, Denecker, Geertrui, HEEMSKERK, VH, VAN 'T VEER, C, Vandenabeele, Peter, WOLFS, TGAM   +6 more
core   +3 more sources

The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi‐Morbidity

AGING MEDICINE, EarlyView.
Exosomes transporting miRNAs play a crucial bidirectional regulatory role in the process of sarcopenia, both in natural aging and under various pathological conditions. ABSTRACT Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease ...
Bingyu Huang, Zhao Peng, Lin Kang
wiley   +1 more source

Ischemic preconditioning: Interruption of various

Journal of the Saudi Heart Association, 2017
Ischemic heart diseases are the leading cause of morbidity and mortality worldwide. Reperfusion of an ischemic heart is necessary to regain the normal functioning of the heart. However, abrupt reperfusion of an ischemic heart elicits a cascade of adverse
Ahsas Goyal, Neetu Agrawal
doaj   +1 more source