P2X7 Receptors in Astrocytes: A Switch for Ischemic Tolerance [PDF]
Molecules, 2022 A sub-lethal ischemic episode (preconditioning [PC]) protects neurons against a subsequent lethal ischemic injury. This phenomenon is known as ischemic tolerance.
Yuri Hirayama +3 more
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Ischemic Tolerance—A Way to Reduce the Extent of Ischemia–Reperfusion Damage [PDF]
Cells, 2023 Individual tissues have significantly different resistance to ischemia–reperfusion damage. There is still no adequate treatment for the consequences of ischemia–reperfusion damage.
Rastislav Burda +2 more
doaj +4 more sources
The Perspective of Using Ischemic Tolerance in Clinical Practice [PDF]
BiomedicinesIschemic–reperfusion injury represents an extremely serious problem in the human population. It mainly affects the elderly population and currently used treatments have poor results.
Rastislav Burda +2 more
doaj +3 more sources
Review Cerebral Ischemic Tolerance and Preconditioning: Methods, Mechanisms, Clinical Applications, and Challenges [PDF]
Frontiers in Neurology, 2020 Stroke is one of the leading causes of morbidity and mortality worldwide, and it is increasing in prevalence. The limited therapeutic window and potential severe side effects prevent the widespread clinical application of the venous injection of ...
Yulei Hao +6 more
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Immune mechanisms in cerebral ischemic tolerance [PDF]
Frontiers in Neuroscience, 2014 Stressor-induced tolerance is a central mechanism in the response of bacteria, plants, and animals to potentially harmful environmental challenges.
Lidia eGarcia-Bonilla +4 more
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Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors [PDF]
Biomolecules, 2022 In this study, we characterize biophysical changes in NMDA receptor function in response to brief non-injurious ischemic stress (ischemic preconditioning).
Mian Xie +6 more
doaj +2 more sources
Plasma metabolomic profiling of patients with transient ischemic attack reveals positive role of neutrophils in ischemic toleranceResearch in context [PDF]
EBioMedicine, 2023 Summary: Background: Transient ischemic attack (TIA) induces ischemic tolerance that can reduce the subsequent ischemic damage and improve prognosis of patients with stroke. However, the underlying mechanisms remain elusive.
Rongrong Liu +3 more
doaj +2 more sources
Genome-Wide Transcription Analysis of Electroacupuncture Precondition-Induced Ischemic Tolerance on SD Rat With Ischemia–Reperfusion Injury [PDF]
Frontiers in Genetics, 2021 Acupuncture promotes the recovery of neurological function by the overall improvement of ischemic brain injury. It is not only regarded as a rehabilitative treatment but also a pretreatment method for stroke.
Shuping Fu +11 more
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SOD1 regulates CXCR4 transcription in cortical neurons for establishment of cerebral ischemic tolerance [PDF]
Journal of Advanced ResearchIntroduction: Understanding of cerebral ischemic tolerance could provide important insight into viable neuroprotective strategies against ischemic stroke.
Ming-Xi Li +5 more
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3-Weeks of Exercise Training Increases Ischemic-Tolerance in Hearts From High-Fat Diet Fed Mice [PDF]
Frontiers in Physiology, 2019 Physical activity is an efficient strategy to delay development of obesity and insulin resistance, and thus the progression of obesity/diabetes-related cardiomyopathy.
Neoma T. Boardman +4 more
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