Results 11 to 20 of about 865,811 (229)
Dynamic changes in DNA methylation in ischemic tolerance [PDF]
Frontiers in Neurology, 2015 Epigenetic mediators of gene expression are hypothesized to regulate transcriptomic responses to preconditioning ischemia and ischemic tolerance. Here we utilized a methyl-DNA enrichment protocol and sequencing (ChIP-seq) to identify patterns of DNA ...
Robert eMeller +2 more
doaj +4 more sources
Mechanisms and Prospects of Ischemic Tolerance Induced by Cerebral Preconditioning [PDF]
International Neurourology Journal, 2010 In the brain, brief episodes of ischemia induce tolerance against a subsequent severe episode of ischemia. This phenomenon of endogenous neuroprotection is known as preconditioning-induced ischemic tolerance.
Mohammad Iqbal Hossain Bhuiyan +1 more
doaj +2 more sources
Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection [PDF]
Cardiovascular Diabetology, 2017 Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause of death in diabetes mellitus (DM). In addition to eliciting cardiomyopathy, DM induces a ‘wicked triumvirate’: (i) increasing the risk and incidence of IHD and ...
Jake Russell +4 more
doaj +2 more sources
Ischemic Tolerance Induced by Glial Cells [PDF]
Neurochemical Research, 2022 Schuichi Koizumi, Yuri Hirayama
exaly +2 more sources
Role of homocysteine in the ischemic stroke nad development of ischemic tolerance [PDF]
Frontiers in Neuroscience, 2016 Homocysteine (Hcy) is a toxic, sulfur-containing intermediate of methionine metabolism. Hyperhomocysteinemia (hHcy), as a consequence of impaired Hcy metabolism or defects in crucial co-factors that participate in its recycling, is assumed as an ...
Jan Lehotsky +7 more
doaj +2 more sources
Frontiers in Immunology, 2022 The development of tolerance triggered by a sublethal ischemic episode (preconditioning, PC) involves a complex crosstalk between neurons, astrocytes and microglia, although the role of the peripheral immune system in this context is largely unexplored ...
Diana Amantea +7 more
doaj +1 more source
Stroke: Vascular and Interventional Neurology, 2022 Background Electrical stimulation of the cerebellar fastigial nucleus (FN) reduces the infarct size induced by middle cerebral artery occlusion in rats.
Yasuko Fukushi +5 more
doaj +1 more source
Ischemic Tolerance of the Brain and Spinal Cord: A Review [PDF]
Neurologia Medico-Chirurgica, 2017 Atsuhito Uneda +2 more
exaly +2 more sources
Frontiers in Molecular Neuroscience, 2022 Epileptic seizures result in pronounced over-expression of neuropeptide Y (NPY). In vivo and in vitro studies revealed that NPY exerts potent anticonvulsive actions through presynaptic Y2 receptors by suppressing glutamate release from principal neurons.
Meinrad Drexel, Günther Sperk
doaj +1 more source
Ischemic preconditioning treatment of astrocytes transfers ischemic tolerance to neurons. [PDF]
Cond Med, 2017 Ischemic preconditioning (IPC) represents a potential therapy against cerebral ischemia. While our group has previously shown IPC to induce neuroprotection through various pathways, the role of astrocytes in supporting IPC-induced neuroprotection has not
Narayanan SV, Perez-Pinzon MA.
europepmc +5 more sources