Ischemic Tolerance – Blessing or Curse [PDF]
Physiological Research, 2021 Application of knowledge about ischemic tolerance to clinic requires the solid understanding of mechanism of creation of this phenomenon. This review summarizes research that has been carried out in many laboratories over a long period of time, but the main focus will be on own experimental research.
J, Burda, R, Burda
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P2X7 Receptors in Astrocytes: A Switch for Ischemic Tolerance [PDF]
Molecules, 2022 A sub-lethal ischemic episode (preconditioning [PC]) protects neurons against a subsequent lethal ischemic injury. This phenomenon is known as ischemic tolerance.
Yuri Hirayama +3 more
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Plasma metabolomic profiling of patients with transient ischemic attack reveals positive role of neutrophils in ischemic toleranceResearch in context [PDF]
EBioMedicine, 2023 Summary: Background: Transient ischemic attack (TIA) induces ischemic tolerance that can reduce the subsequent ischemic damage and improve prognosis of patients with stroke. However, the underlying mechanisms remain elusive.
Rongrong Liu +3 more
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The Perspective of Using Ischemic Tolerance in Clinical Practice [PDF]
BiomedicinesIschemic–reperfusion injury represents an extremely serious problem in the human population. It mainly affects the elderly population and currently used treatments have poor results.
Rastislav Burda +2 more
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Review Cerebral Ischemic Tolerance and Preconditioning: Methods, Mechanisms, Clinical Applications, and Challenges [PDF]
Frontiers in Neurology, 2020 Stroke is one of the leading causes of morbidity and mortality worldwide, and it is increasing in prevalence. The limited therapeutic window and potential severe side effects prevent the widespread clinical application of the venous injection of ...
Yulei Hao +6 more
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Astrocyte-Mediated Ischemic Tolerance [PDF]
The Journal of Neuroscience, 2015 Preconditioning (PC) using a preceding sublethal ischemic insult is an attractive strategy for protecting neurons by inducing ischemic tolerance in the brain. Although the underlying molecular mechanisms have been extensively studied, almost all studies have focused on neurons.
Yuri Hirayama +5 more
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3-Weeks of Exercise Training Increases Ischemic-Tolerance in Hearts From High-Fat Diet Fed Mice [PDF]
Frontiers in Physiology, 2019 Physical activity is an efficient strategy to delay development of obesity and insulin resistance, and thus the progression of obesity/diabetes-related cardiomyopathy.
Neoma T. Boardman +4 more
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Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection [PDF]
Cardiovascular Diabetology, 2017 Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause of death in diabetes mellitus (DM). In addition to eliciting cardiomyopathy, DM induces a ‘wicked triumvirate’: (i) increasing the risk and incidence of IHD and ...
Jake Russell +4 more
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Frontiers in Molecular Neuroscience, 2022 Epileptic seizures result in pronounced over-expression of neuropeptide Y (NPY). In vivo and in vitro studies revealed that NPY exerts potent anticonvulsive actions through presynaptic Y2 receptors by suppressing glutamate release from principal neurons.
Meinrad Drexel, Günther Sperk
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Ischemic tolerance in stroke treatment [PDF]
Expert Review of Cardiovascular Therapy, 2009 Although outcome after stroke treatment has significantly improved over the last 30 years, there has been no revolutionary breakthrough. Among different combined approaches, systemic thrombolysis in combination with neuroprotection became a favorite research target.
Sandu N +5 more
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