Results 21 to 30 of about 63,266 (244)
Journal of Cerebral Blood Flow & Metabolism, 1997 A brief period of cerebral ischemia confers transient tolerance to a subsequent ischemic challenge in the brain. This phenomenon of ischemic tolerance has been confirmed in various animal models of forebrain ischemia and focal cerebral ischemia. Since the ischemic tolerance afforded by preceding ischemia can bring about robust protection of the brain ...
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Frontiers in Molecular Neuroscience, 2018 Hibernating 13-lined ground squirrels (Ictidomys tridecemlineatus; TLGS) rank among the most brain hypoperfusion-tolerant mammals known. Herein we provide some evidence of cycling between an epithelial phenotype and a hybrid epithelial/mesenchymal (E/M ...
Yang-ja Lee +3 more
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New role of astrocytes in neuroprotective mechanisms after ischemic stroke
Arquivos de Neuro-Psiquiatria, 2023 Astrocytes are the most abundant cell subtypes in the central nervous system. Previous studies believed that astrocytes are supporting cells in the brain, which only provide nutrients for neurons.
Xiaoyun Xie, Jingli Liu
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eLife, 2020 Many organisms in nature have evolved mechanisms to tolerate severe hypoxia or ischemia, including the hibernation-capable Arctic ground squirrel (AGS).
Neel S Singhal +5 more
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SUMOylation participates in induction of ischemic tolerance [PDF]
Journal of Neurochemistry, 2009 AbstractGround squirrels in hibernation torpor have been shown to have striking increases in global SUMOylation on tissue immunoblots. Here, we find evidence that global SUMOylation is also involved in ischemic tolerance in primary cortical neuronal cultures (from rats and mice) and SHSY5Y human neuroblastoma cells.
Yang Ja, Lee +5 more
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HBA1C level and its role on ischemic stroke patients with prediabetes [PDF]
Romanian Journal of Neurology, 2023 Background. Stroke is the highest cause of death in Indonesia. Impaired glucose tolerance becomes one of the metabolic risk factors that contribute to ischemic stroke. This study will observe the role of HbA1c level on ischemic stroke in “Dr.
Abdul Gofir +3 more
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The Uremic Myocardium and Ischemic Tolerance [PDF]
Circulation, 2012 Uremia is associated with an increased prevalence of ischemic heart disease. Already, at the start of dialysis, the prevalence of coronary artery disease is 38%.1 The frequency of myocardial infarction in renal patients is high and the outcome is poor.2 Despite significant improvement of therapeutic modalities, the unadjusted 2-year mortality for ...
Ralf, Dikow, Stefan E, Hardt
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Hypothermia Protects and Prolongs the Tolerance Time of Retinal Ganglion Cells against Ischemia. [PDF]
PLoS ONE, 2016 PURPOSE:Hypothermia has been shown to be neuroprotective in the therapy of ischemic stroke in the brain. To date no studies exist on the level of the inner retina and it is unclear if hypothermia would prolong the ischemic tolerance time of retinal ...
Maximilian Schultheiss +9 more
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Nascent proteomes of ischemic-injured and ischemic-tolerant neuronal cells [PDF]
International Journal of Computational Biology and Drug Design, 2011 In a recent study on ischemic rodent brains, we quantitatively characterised and compared brain proteomes under ischemic-preconditioned or injured or tolerant conditions. We discovered an enriched presence of repressive transcriptional regulator proteins with essential roles as epigenetic regulators in ischemic-tolerant brains (Stapels et al., 2010 ...
An Zhou, Roger Simon, Larry David
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Journal of Pharmacological Sciences, 2005 Excessive elevation of intracellular calcium level seems to be a trigger of ischemic neuronal injury. Calcium/calmodulin (CaM)-dependent protein kinase kinase (CaM-KK) is an upstream kinase for CaM kinase IV (CaM-KIV) that was reported to prevent ...
Shigetoshi Yano +3 more
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