Results 81 to 90 of about 50,311 (298)

Myocardial apoptosis and ischemic preconditioning [PDF]

Cardiovascular Research, 2002
Necrosis and apoptosis are two forms of cell death in the myocardium that have been associated with ischemia and reperfusion. Although it has been well documented that necrosis, as a major form of myocyte cell death, rapidly leads to a destruction of a large group of cells after myocardial ischemia and reperfusion, the induction of apoptosis in ...
Zhi-Qing, Zhao, Jakob, Vinten-Johansen
openaire   +2 more sources

Multimodal Assessment of Kidney Quality During 24‐h of Normothermic Machine Perfusion

Artificial Organs, EarlyView.
Normothermic machine perfusion (NMP) has emerged as a promising tool for assessing kidney quality prior to transplantation; however, reliable biomarkers remain to be established. In this study, thirteen porcine kidneys were perfused for 24 h using an autologous leukocyte‐filtered whole blood‐based perfusate applying urine recirculation.
Marlene Pühringer, Magdalena Kött, Andras T. Meszaros, Michael J. Blumer, Bettina Zelger, Stefan Redl, Martin Hermann, Thomas Resch, Simon Mathis, Gabriel Putzer, Judith Martini, Christina Bogensperger, Franka Messner, Julia Hofmann, Margot Fodor, Andrea Griesmacher, Annemarie Weissenbacher, Theresa Hautz, Gert Mayer, Hannes Neuwirt, Gerald Brandacher, Silvia Oberparleiter, Stefan Schneeberger   +22 more
wiley   +1 more source

Improved resistance to ischemia and reperfusion, but impaired protection by ischemic preconditioning in patients with type 1 diabetes mellitus: a pilot study

Cardiovascular Diabetology, 2012
Background In patients with type 1 diabetes mellitus (T1DM), cardiovascular events are more common, and the outcome following a myocardial infarction is worse than in nondiabetic subjects.
Engbersen Richard, Riksen Niels P, Mol Marc J, Bravenboer Bert, Boerman Otto C, Meijer Patrick, Oyen Wim JG, Tack Cees, Rongen Gerard A, Smits Paul   +9 more
doaj   +1 more source

The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]

, 2012
This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L, Krafft, Paul R, Leitzke, Arthur S, Tang, Jiping, Van Allen, Nicole R, Zhang, John H   +5 more
core   +1 more source

Development of a Swine Whole Eye Transplant Ex Vivo Perfusion Protocol

Artificial Organs, EarlyView.
This study establishes the first subnormothermic machine perfusion protocol for whole eye transplants in a swine model, enabling up to 18 h of preservation with stable metabolic function, limited edema, and recovery of mydriasis. ABSTRACT Background The first human Whole Eye Transplant (WET) has sparked new hope for patients who have lost vision due to
Haïzam Oubari, Lucile Cabanel, Yanis Berkane, Ali Mojallal, Mark A. Randolph, Basak Uygun, Korkut Uygun, Curtis L. Cetrulo Jr., Alexandre G. Lellouch   +8 more
wiley   +1 more source

Two Weeks of Ischemic Conditioning Improves Walking Speed and Reduces Neuromuscular Fatigability in Chronic Stroke Survivors [PDF]

, 2019
This pilot study examined whether ischemic conditioning (IC), a noninvasive, cost-effective, and easy-to-administer intervention, could improve gait speed and paretic leg muscle function in stroke survivors. We hypothesized that 2 wk of IC training would
Alqahtani, Saad Z., Boerger, Timothy F., Durand, Matthew J., Gutterman, David D., Hyngstrom, Allison S., Nguyen, Jennifer, Schmit, Brian D., Wright, Michael T.   +7 more
core   +1 more source

Endothelial preconditioning by transient oxidative stress reduces inflammatory responses of cultured endothelial cells to TNF-α [PDF]

, 2000
Brief episodes of ischemia can render an organ resistant to subsequent severe ischemia. This ‘ischemic preconditioning’ is ascribed to various mechanisms, including oxidative stress. We investigated whether preconditioning exists on an endothelial level.
Akimitsu T., BERNHARD F. BECKER, CHRISTIAN KUPATT, DeFily D. V., Hearse D. J., Hoshida S., Jerome S. N., Schreck R., Schulz R., Siegfried M. R., STEFAN ZAHLER, Yao Z.   +11 more
core   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, EarlyView.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Alternation of gene expression in brain-derived exosomes after cerebral ischemic preconditioning in mice

Heliyon
Aims: Cerebral ischemic preconditioning is a neuroprotective therapy against cerebral ischemia and ischemia-reperfusion injury. This study aims to demonstrate the alternation of gene expression in exosomes from brain tissue of mice after ischemic ...
He Li, Xiaoxi Zhang, Hongye Xu, Hanchen Liu, Yongxin Zhang, Lei Zhang, Yu Zhou, Yongwei Zhang, Jianmin Liu, Mei Jing, Ping Zhang, Pengfei Yang   +11 more
doaj   +1 more source

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection [PDF]

, 2015
Ischemic preconditioning is the phenomenon whereby brief periods of sublethal ischemia protect against a subsequent, more prolonged, ischemic insult. In remote ischemic preconditioning (RIPC), ischemia to one organ protects others organs at a distance ...
Baik, Alan H., Chakraborty, Abhishek A., Clish, Clary B., Davidson, Shawn M, Gibson, William J., Hanse, Eric A., Kaelin, William G., Kelekar, Ameeta, Miller, Christine M., Moslehi, Javid, Olenchock, Benjamin A., Pierce, Kerry A., Sullivan, Lucas Bryan, Vander Heiden, Matthew G., Wagers, Amy J., Williams, Jeremy   +15 more
core   +1 more source