Results 11 to 20 of about 50,595 (277)

Epsilon PKC increases brain mitochondrial SIRT1 protein levels via heat shock protein 90 following ischemic preconditioning in rats. [PDF]

PLoS ONE, 2013
Ischemic preconditioning is a neuroprotective mechanism whereby a sublethal ischemic exposure is protective against a subsequent lethal ischemic attack. We previously demonstrated that SIRT1, a nuclear localized stress-activated deacetylase, is vital for
John W Thompson, Kunjan R Dave, Isabel Saul, Srinivasan V Narayanan, Miguel A Perez-Pinzon   +4 more
doaj   +1 more source

Cerebral Ischemic Preconditioning Aggravates Death of Oligodendrocytes

Biomolecules, 2022
Neurodegeneration can benefit from ischemic preconditioning, a natural adaptive reaction to sublethal noxious stimuli. Although there is growing interest in advancing preconditioning to preserve brain function, preconditioning is not yet considered ...
Teng Guan, Ying Guo, Chengren Li, Ting Zhou, Qiang Yu, Chaoxian Yang, Guohui Zhang, Jiming Kong   +7 more
doaj   +1 more source

Connexin43 and Ischemic Preconditioning [PDF]

Cardiovascular Research, 2004
Connexin43 (Cx43) is the essential protein to form hemichannels and gap junctions in the myocardium. The phosphorylation status of Cx43 which is regulated by a variety of protein kinases and phosphatases determines hemichannel and/or gap junction conductance and permeability.
Rainer, Schulz, Gerd, Heusch
openaire   +3 more sources

Short-duration ischemic preconditioning does not improve jump or change of direction performance in elite male handball players. [PDF]

PLoS One
Kamiş O, Akçay N, Keskin K, Rolnick N, García Sánchez C, de Queiros VS, Turhan FH, Vieira JG, Montoye A, Aniceto RR.   +9 more
europepmc   +2 more sources

Viability assessment and transplantation of fatty liver grafts using end‐ischemic normothermic machine perfusion

Liver Transplantation, EarlyView., 2022
Abstract End‐ischemic viability testing by normothermic machine perfusion (NMP) represents an effective strategy to recover liver grafts having initially been discarded for liver transplantation (LT). However, its results in the setting of significant (≥30%) macrovesicular steatosis (MaS) have not been specifically assessed.
Damiano Patrono, Riccardo De Carlis, Alessandro Gambella, Francesca Farnesi, Alice Podestà, Andrea Lauterio, Francesco Tandoi, Luciano De Carlis, Renato Romagnoli   +8 more
wiley   +1 more source

Mechanisms and Prospects of Ischemic Tolerance Induced by Cerebral Preconditioning [PDF]

International Neurourology Journal, 2010
In the brain, brief episodes of ischemia induce tolerance against a subsequent severe episode of ischemia. This phenomenon of endogenous neuroprotection is known as preconditioning-induced ischemic tolerance.
Mohammad Iqbal Hossain Bhuiyan, Youn Jung Kim   +1 more
doaj   +1 more source

Ischemic Preconditioning [PDF]

Stroke, 2004
The quest for effective therapeutics for the treatment of stroke has resulted in more than a dozen clinical trials of putative neuroprotective drugs. None has proven successful. Although trial design may be a factor in these failures, the negative results of these attempts to find effective exogenous therapies for cerebral ischemia have stimulated ...
Antoine Hakim, Roger Simon
openaire   +1 more source

Novel role for the innate immune receptor toll-like receptor 4 (TLR4) in the regulation of the wnt signaling pathway and photoreceptor apoptosis [PDF]

, 2012
Recent evidence has implicated innate immunity in regulating neuronal survival in the brain during stroke and other neurodegenerations. Photoreceptors are specialized light-detecting neurons in the retina that are essential for vision.
A Poltorak, A Wenzel, Abigail S. Hackam, AK Silva, AL Kindzelskii, Amit K. Patel, AO Edwards, AS Hackam, B Marsh, BJ Marsh, BJ Marsh, C Bowes, C Liu, C Niehrs, C Zhang, Chhinder P. Sodhi, CP Sodhi, CY Logan, D Jiang, David J. Hackam, DJ Kaczorowski, E Cario, E Chaum, E Okun, F Hua, F Limana, G Faraco, G Tezel, GA Limb, GM Seigel, GR Barile, GS Hageman, GT Higgins, H Yi, H Yi, HL Rosenzweig, HL Rosenzweig, HP Scholl, Hyun Yi, IA El-Ghrably, J Merenmies, J Qiu, J Watson, JK Shen, JR Caso, K Hoshino, K Kaarniranta, K Miyake, K Takeda, KP Mollen, L Barandon, L Minghetti, M Mizukami, MA Fragoso, Mauricio Martins Rodrigues, MD Gordon, MK Ko, MT Lotze, N Arimura, P Matzinger, PJ Franco, PY Leung, Q Xing, R Gauthier, R Gorina, R Kacimi, R Seitz, R Shechter, RM Vabulas, RR Caspi, RT Moon, S Lehnardt, S Lin, S Tell, S Walter, S Zareparsi, SC Gribar, SC Tang, SC Tang, SR Coats, T Ha, T Harada, T Harada, T Nakazawa, U Kilic, V Bocchini, V Fontaine, Y de Kozak, Y Xin, Z Tu   +89 more
core   +14 more sources

Alleviation of ischemic brain injury by exercise preconditioning is associated with modulation of autophagy and mitochondrial dynamics in cerebral cortex of female aged mice

Experimental Gerontology, 2023
Evidence from clinical studies and preclinical studies supports that exercise preconditioning can not only reduce the risk of stroke but also improve brain tissue and functional outcome after stroke.
Yuan-Yuan Qin, Shan-Yao Pan, Jia-Ru Dai, Qing-Mei Wang, Xun Luo, Zheng-Hong Qin, Li Luo   +6 more
doaj   +1 more source

Effects of remote limb ischemic conditioning on muscle strength in healthy young adults: A randomized controlled trial [PDF]

, 2020
Remote limb ischemic conditioning (RLIC) is a clinically feasible method in which brief, sub-lethal bouts of ischemia protects remote organs or tissues from subsequent ischemic injury.
Bland, Marghuretta D, Chen, Ling, Gidday, Jeffrey M, Hershey, Tamara, Lang, Catherine E, Lee, Jin-Moo, Mattlage, Anna E, Surkar, Swati M   +7 more
core   +2 more sources