Results 121 to 130 of about 121,748 (297)

Islet organoids: a new hope for islet transplantation in diabetes

open access: yesFrontiers in Immunology
Diabetes mellitus, including Type 1 diabetes (T1D) and advanced Type 2 diabetes (T2D), remains a major global health challenge due to the destruction or dysfunction of insulin-producing β-cells. Islet transplantation offers a promising therapeutic strategy. However, it is limited by organ shortage globally and other risk factors. Recent advancements in
Xuemei Yu   +6 more
openaire   +3 more sources

Bahaman patch reefs: Numerous and neglected

open access: yesThe Depositional Record, EarlyView.
Abstract Phanerozoic patch reefs are extensively studied because they are abundant and are potential reservoirs for valuable fluids. In contrast, geologic studies of modern reefs have largely focused on platform margins, leaving patch reefs comparatively neglected. What conditions favour patch‐reef development?
Paul Enos, Clay Robertson
wiley   +1 more source

Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response

open access: yesiScience, 2018
Summary: Impaired pancreatic β-cell survival contributes to the reduced β-cell mass in diabetes, but underlying regulatory mechanisms and key players in this process remain incompletely understood.
Kanaka Durga Devi Gorrepati   +5 more
doaj  

Effects of the Dietary Supplement 5α‐Hydroxy‐Laxogenin in the Orchiectomized Rat Model

open access: yesDrug Testing and Analysis, EarlyView.
The dietary supplement ingredient 5α‐hydroxy‐laxogenin was investigated in the castrated male rat for potential androgenic and anabolic effects. Moreover, androgen receptor binding of 5α‐hydroxy‐laxogenin was modelled by in silico docking. While molecular modelling supports androgen receptor binding, we observed neither androgenic nor anabolic effects ...
Daniel Derwand   +4 more
wiley   +1 more source

A Practical Guide to Rodent Islet Isolation and Assessment

open access: yesBiological Procedures Online, 2009
Pancreatic islets of Langerhans secrete hormones that are vital to the regulation of blood glucose and are, therefore, a key focus of diabetes research. Purifying viable and functional islets from the pancreas for study is an intricate process.
Carter Jeffrey   +4 more
doaj  

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy