Results 81 to 90 of about 121,748 (297)

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, EarlyView.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source

Water‐Soluble Molecular Wires for Membrane Potential Imaging

Angewandte Chemie, EarlyView.
Fully water‐soluble fluorescent rosamine‐based amphiphilic molecular wires were developed for imaging membrane potentials. The performance of the probes was evaluated in single cardiomyocytes, murine pituitary gland, and islets of Langerhans.
Mirna El Khatib, Margret A. Fye, Keita Uchida, Ana L. Obaid, Thomas Troxler, Dylan Valente, Brian M. Salzberg, Benjamin Prosser, Irina N. Kaverina, Sergei A. Vinogradov   +9 more
wiley   +2 more sources

BRD4 Signaling Maintains the Differentiated State of β Cells

Advanced Science, EarlyView.
The comprehensive exploration revealed the critical role of BRD4 in β cells. BRD4 plays a fundamental role in maintaining β cell differentiation because both long‐term and acute BRD4 deficiency result in a reduction in insulin secretion and downregulation of differentiation markers.
Fuqiang Liu, Guang Liu, Jia Song, Yujing Sun, Mengmeng Yang, Hualin Liu, Hongkai Zhao, Jiamu Chen, Qincheng Qiao, Siyue Li, Chenglong Yu, Jingru Qu, Ying Zou, Tixiao Wang, Jidong Liu, Lei Zhao, Huihui Tian, Tao Huang, Manna Zhang, Li Chen, Ruxing Zhao, Yuanyuan Du, Xinguo Hou   +22 more
wiley   +1 more source

The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

eLife
The gain-of-function mutation in the TALK-1 K+ channel (p.L114P) is associated with maturity-onset diabetes of the young (MODY). TALK-1 is a key regulator of β-cell electrical activity and glucose-stimulated insulin secretion.
Arya Y Nakhe, Prasanna K Dadi, Jinsun Kim, Matthew T Dickerson, Soma Behera, Jordyn R Dobson, Shristi Shrestha, Jean-Philippe Cartailler, Leesa Sampson, Mark A Magnuson, David A Jacobson   +10 more
doaj   +1 more source

YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis

Advanced Science, EarlyView.
This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li, Xueying Li, Chunhong Liu, Zhenzhi Li, Kaixin Ding, Yuxin Wang, Ning Gu, Liwei Xie, Zheng Chen   +8 more
wiley   +1 more source

Development Status and Future Prospects of Hydrogen Energy Technology: Production, Storage, and Cost Analysis

Advanced Energy and Sustainability Research, EarlyView.
Hydrogen is an energy carrier, produced from renewable and nonrenewable resources. It can be stored in a variety of materials and transported to distant locations. This article reviews progress in hydrogen technology by looking at environmental and economic impact, cost analysis, and policy support at government level as way forward for bringing it to ...
Xuexue Pan, Houhua Zhou, Dinmukhambet Baimbetov, Samal Syrlybekkyzy, Berik Bakhytzhanovich Akhmetov, Qamar Abbas   +5 more
wiley   +1 more source

Transcriptional Regulation of Chemokine Genes: A Link to Pancreatic Islet Inflammation?

Biomolecules, 2015
Enhanced expression of chemotactic cytokines (aka chemokines) within pancreatic islets likely contributes to islet inflammation by regulating the recruitment and activation of various leukocyte populations, including macrophages, neutrophils, and T ...
Susan J. Burke, J. Jason Collier
doaj   +1 more source

Conditional Survival for Pancreas Graft and Its Associated Factors After Pancreas Transplantation

Annals of Gastroenterological Surgery, EarlyView.
This study investigates conditional survival (CS) for pancreas grafts in recipients of pancreas transplantation (PTx) in Japan, using data from 526 cases. Findings reveal that CS increases over time post‐transplant, offering a more optimistic long‐term prognosis than traditional actuarial survival. While donor sex and PTx procedure type influence early
Yoshito Tomimaru, Toshinori Ito, Tetsuhisa Kitamura, Takashi Kenmochi, Yuichiro Doki, Hidetoshi Eguchi   +5 more
wiley   +1 more source

New Neuronal Subtypes With a “Pre-Pancreatic” Signature in the Sea Urchin Stongylocentrotus purpuratus

Frontiers in Endocrinology, 2018
Neurons and pancreatic endocrine cells have a common physiology and express a similar toolkit of transcription factors during development. To explain these common features, it has been hypothesized that pancreatic cells most likely co-opted a pre ...
Margherita Perillo, Periklis Paganos, Teresa Mattiello, Maria Cocurullo, Paola Oliveri, Maria I. Arnone   +5 more
doaj   +1 more source

Intermittent intraperitoneal implantation of islets in rat islet transplantation

Cell Transplantation, 1996
Two critical issues need to be addressed regarding islet cell transplantation: obtaining sufficient supply of cells for implantation, and the maintenance of the viability of these cells. Our present study has two protocols. One is islet cell implantation under the renal capsule, and the other, repeated injection of islet cells into the peritoneal ...
Hideto Sakimoto, Yasuhiko Fukuda, Hiroo Iwata, Takashi Urushihara, Kiyohiko Dohi, Hirotaka Tashiro, M. Ikeda, Masahiro Nishihara, Kouichi Okugawa   +8 more
openaire   +3 more sources