Results 101 to 110 of about 20,996 (256)
The relationship between diabetes and pancreatic cancer [PDF]
, 2003 About 80% of pancreatic cancer patients have glucose intolerance or frank diabetes. This observation has led to the following two hypotheses: i. pancreatic cancer causes the associated diabetes and ii.
Wang, F +3 more
core +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.Holothuria leucospilota n‐hexane extract shows antidiabetic, anti‐inflammatory, and anti‐apoptotic effects in STZ‐induced diabetic rats. The extract modulates key pathways in glucose metabolism, insulin secretion, inflammation, and apoptosis. Treatment significantly decreased glucose and amyloid beta levels, increased insulin, and improved glycemic ...
Niloufar Darbandi +1 more
wiley +1 more source
Scientific Reports, 2018 The formation of amyloid fibrils by human islet amyloid polypeptide protein (hIAPP) has been implicated in pancreas dysfunction and diabetes. However, efficient treatment options to reduce amyloid fibrils in vivo are still lacking.
Andras Franko +15 more
semanticscholar +1 more source
A Tetramer Derived from Islet Amyloid Polypeptide
The Journal of Organic Chemistry, 2017 Aggregation of the islet amyloid polypeptide (IAPP) to form fibrils and oligomers is important in the progression of type 2 diabetes. This article describes X-ray crystallographic and solution-state NMR studies of peptides derived from residues 11-17 of IAPP that assemble to form tetramers.
Yilin Wang +3 more
openaire +5 more sources
Sulfated Polysaccharides in the Hallmarks of Metabolic Syndrome: Functions and Mechanisms
Food Frontiers, Volume 7, Issue 1, January 2026.The SPs sources are very diverse, including various fishes, sea cucumbers, seaweeds, etc. These SPs are able to improve the glucose and lipid metabolism disorders, hormonal dysregulation, oxidative stress, inflammatory response, complications, and gut homeostasis of MetS by regulating biochemical indicators related to MetS. ABSTRACT Metabolic syndrome (
Fuqiang Zhao +9 more
wiley +1 more source
The Scientific World Journal, 2003 Amylin (islet amyloid polypeptide) is a peptide synthesized principally in the b-cells of the pancreatic islets together with insulin and has actions as a hormone, growth factor, and modifier of behavior.
Peter J. Wookey +3 more
doaj +1 more source
What's in a Name? Classification of Diabetes Mellitus in Veterinary Medicine and Why It Matters [PDF]
, 2016 Diabetes Mellitus (DM) is a syndrome caused by various etiologies. The clinical manifestations of DM are not indicative of the cause of the disease, but might be indicative of the stage and severity of the disease process.
Abdul-Rasoul +110 more
core +3 more sources
IET Nanobiotechnology, Volume 2026, Issue 1, 2026.Human islet amyloid polypeptide (hIAPP) oligomers, formed through an accumulation pathway, are toxic to insulin‐secreting pancreatic β‐cells and are considered to contribute for β‐cell death and insulin deficiency commonly observed in type 2 diabetes (T2D) patients.
Mahboobeh Nazari +8 more
wiley +1 more source
Interaction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide. [PDF]
PLoS ONE, 2011 Assembly of amyloid-beta peptide (Aβ) into cytotoxic oligomeric and fibrillar aggregates is believed to be a major pathologic event in Alzheimer's disease (AD) and interfering with Aβ aggregation is an important strategy in the development of novel ...
Nasrollah Rezaei-Ghaleh +4 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Accumulation of islet amyloid polypeptide (IAPP)-containing amyloid fibrils is the main pathological finding in pancreatic islets in type 2 diabetes.
M. Oskarsson +6 more
semanticscholar +1 more source