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Polyphenol Interactions with Amyloid Fibrils: A Molecular Docking Study
East European Journal of PhysicsPolyphenols, a versatile group of naturally occurring compounds with many favorable biological properties currently attract increasing research interest in the context of their ability to inhibit the formation and to destabilize special protein ...
Uliana Malovytsia +5 more
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A Novel Pentapeptide Inhibitor Reduces Amyloid Deposit Formation by Direct Interaction with hIAPP
International Journal of Endocrinology, 2019 Backgrounds. The presence of amyloid deposits of human islet amyloid polypeptide (hIAPP) in islet β-cells has been associated with type 2 diabetes occurrence and islet graft failure.
Yue Shi +4 more
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Upsala Journal of Medical Sciences, 2017 Background: Enhanced IAPP production may contribute to islet amyloid formation in type 2 diabetes. The objective of this study was to determine the effects of the saturated fatty acid palmitate on IAPP levels in human β-cells.
Camilla Krizhanovskii +4 more
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A small molecule improves diabetes in mice expressing human islet amyloid polypeptide. [PDF]
Islets, 2023 Bhagat V, Verchere CB.
europepmc +1 more source
A pancreatic player in dementia: pathological role for islet amyloid polypeptide accumulation in the brain. [PDF]
Neural Regen Res, 2023 Bortoletto AS, Parchem RJ.
europepmc +1 more source
Clinical Interventions in Aging, 2015 Hye Rin Jeong, Seong Soo A AnDepartment of Bionano Technology, Gachon Medical Research Institute, Gachon University, Gyeonggi-do, Republic of KoreaAbstract: Human islet amyloid polypeptide (h-IAPP) is a peptide hormone that is synthesized and cosecreted ...
Jeong HR, An SSA
doaj