Results 61 to 70 of about 6,150 (181)
Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate. [PDF]
PLoS ONE, 2016 Pancreatic amyloid formation by islet amyloid polypeptide (IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta-cells and co-secreted with insulin to maintain glucose homeostasis.
Ingrid C Rulifson +16 more
doaj +1 more source
Small, Volume 22, Issue 41, 22 July 2026.We present a pathology‐responsive, activity‐based prodrug strategy that tackles multiple hallmarks of Alzheimer's disease (AD). Rationally designed BE compounds convert under oxidative stress into redox‐active aminophenols, neutralizing ROS and redirecting both metal‐free and metal‐bound Aβ aggregation.
Jimin Lee +13 more
wiley +1 more source
The Scientific World Journal, 2003 Amylin (islet amyloid polypeptide) is a peptide synthesized principally in the b-cells of the pancreatic islets together with insulin and has actions as a hormone, growth factor, and modifier of behavior.
Peter J. Wookey +3 more
doaj +1 more source
Small Science, Volume 6, Issue 7, July 2026.We demonstrate that polymeric Janus nanorods (JNRs) delay both oligomerization and fibrillation of human islet amyloid polypeptide (hIAPP) through high‐affinity and sequence‐specific interactions. JNRs display a β‐hairpin mimetic ligand (LP2) on one face, enabling multivalent binding.
Mathilde Jégo +17 more
wiley +1 more source
eLife, 2016 Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and biological measurements, we define the toxic species produced during IAPP ...
Andisheh Abedini +15 more
doaj +1 more source
Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement
Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.At the center the 3D structure of DYRK1A has been displayed. The dual‐function of DYRK1A involved in cancer and neurodegeneration, i.e., its overexpression drives Down syndrome, neurodegenerative disease etc., and underexpression causes intellectual disability, seizures, etc.
Sampriti Paul +2 more
wiley +1 more source
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
A Tetramer Derived from Islet Amyloid Polypeptide
The Journal of Organic Chemistry, 2017 Aggregation of the islet amyloid polypeptide (IAPP) to form fibrils and oligomers is important in the progression of type 2 diabetes. This article describes X-ray crystallographic and solution-state NMR studies of peptides derived from residues 11-17 of IAPP that assemble to form tetramers.
Yilin Wang +3 more
openaire +5 more sources
Idealized Models of Protofilaments of Human Islet Amyloid Polypeptide [PDF]
Journal of Chemical Information and Modeling, 2012 Fibrils formed by assembly of human islet amyloid polypeptide (hIAPP) are found in most patients with type II diabetes. Structurally, these fibrils are composed of multiple protofilaments and are characterized by extended beta sheets, variable helical twists, and different morphologies.
Yiyu Li +3 more
openaire +2 more sources
The Journal of Physiology, Volume 604, Issue 13, Page 5170-5199, 1 July 2026.Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand +2 more
wiley +1 more source