Results 71 to 80 of about 6,150 (181)

RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes

Molecular Metabolism
Objective: Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 diabetes (T2D), but the mechanisms that underlie this process are incompletely ...
Noyonika Mukherjee, Christopher J. Contreras, Li Lin, Kaitlyn A. Colglazier, Egan G. Mather, Michael A. Kalwat, Nathalie Esser, Steven E. Kahn, Andrew T. Templin   +8 more
doaj   +1 more source

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

Molecular Neurodegeneration, 2007
Background Amyloid-related degenerative diseases are associated with the accumulation of misfolded proteins as amyloid fibrils in tissue. In Alzheimer disease (AD), amyloid accumulates in several distinct types of insoluble plaque deposits, intracellular
Rasool Suhail, Thompson Jennifer L, Breydo Leonid, Wu Jessica, Margol Lawrence, Necula Mihaela, Cotman Carl W, Saing Tommy, Sarsoza Floyd, Head Elizabeth, Kayed Rakez, Gurlo Tatyana, Butler Peter, Glabe Charles G   +13 more
doaj   +1 more source

Lipid Dynamics in the Amyloid Cascade Hypothesis: Evaluating the Biological Relevance of In Vitro Models

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle, Fabio Lolicato, Carmelo Tempra, Martina Pannuzzo, Michele F. M. Sciacca, Danilo Milardi, Carmelo La Rosa   +6 more
wiley   +1 more source

Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway

Frontiers in Pharmacology, 2019
The human islet amyloid polypeptide (hIAPP), the major component of islet amyloid deposition, is one of the amyloidogenic peptides and has been associated with β cell loss and dysfunction in type 2 diabetes (T2D).
Jianzhen Lin, Ao Jiao, Ao Jiao, Wu Lv, Chengshuo Zhang, Yue Shi, Zhaoming Yang, Ning Sun, Xiaohang Li, Jialin Zhang   +9 more
doaj   +1 more source

Effect of Surface Chemistry on Islet Amyloid Polypeptide Conformation [PDF]

Biointerphases, 2020
The formation of dense, linear protein arrays (fibrils) is the hallmark of a number of degenerative diseases, such as Alzheimer’s and type-2 diabetes. Protein fibrils have also attracted interest as building blocks for new materials.
openaire   +2 more sources

Electrochemical Assay of Human Islet Amyloid Polypeptide and Its Aggregation

Sensors, 2008
Square wave voltammetry is used in this work to detect human islet amyloid polypeptide (hIAPP) by using the oxidized signal of the tyrosine residue in hIAPP. A detection limit of 1×10-6 M for hIAPP has been obtained. A kinetic study of the aggregation
Genxi Li, Dongmei Zhang, Zhenyu Chen, Nandi Zhou   +3 more
doaj   +1 more source

Membrane-mediated amyloid deposition of human islet amyloid polypeptide [PDF]

Biophysical Reviews, 2017
Amyloid deposition of human islet amyloid polypeptide (hIAPP) within the islet of Langerhans is closely associated with type II diabetes mellitus. Accumulating evidence indicates that the membrane-mediated aggregation and subsequent deposition of hIAPP are linked to the dysfunction and death of insulin-producing pancreatic β-cells, but the molecular ...
openaire   +2 more sources

Porcine islet amyloid polypeptide fragments are refractory to amyloid formation

FEBS Letters, 2010
Of 10 variation sites between sequences of amyloid-resistant porcine islet amyloid polypeptide (pIAPP) and amyloid-prone human IAPP (hIAPP), seven locate within residues 17-29, the most amyloidogenic fragment within hIAPP. To investigate how these variations affect amyloidogenicity, 26 IAPP(17-29) or IAPP(20-29) variants were synthesized and their ...
Zhang, Xin, Cheng, Biao, Gong, Hao, Li, Chuanzhou, Chen, Hong, Zheng, Ling, Huang, Kun   +6 more
openaire   +4 more sources

Amylin Revisited: A 5-Year Perspective on Its Emerging Role in the Treatment of Diabesity

Journal of Obesity & Metabolic Syndrome
Amylin is a pancreatic peptide hormone that regulates blood glucose levels and appetite. This review outlines the physiological role of amylin and highlights recent clinical studies exploring its therapeutic potential in diabetes and obesity.
Chae Won Chung, Jaetaek Kim
doaj   +1 more source

Cell-to-cell transmission of IAPP aggregates in T2DM induces neuronal death by triggering oxidative stress and ferroptosis

Neurobiology of Disease
Type 2 diabetes mellitus (T2DM) is associated with an elevated risk of neurodegenerative diseases, yet the underlying mechanisms remain elusive. A hallmark feature of T2DM is the amyloid deposition of islet amyloid polypeptide (IAPP) in the pancreas ...
Honglin Zheng, Yapei Yuan, Na Zhang, Hang Zhang, Suying Duan, Chenyang Liu, Yaochong Zhang, Qiang Li, Han Liu, Mibo Tang, Haiyang Luo, Yuming Xu   +11 more
doaj   +1 more source