Results 111 to 120 of about 20,996 (256)

Genetically Modified Lactococcus lactis Hypersecreting IL‐1Ra Improves Glucose Metabolism and Modulates the Gut Microbiota in an Obese Mouse Model

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder and typically develops later in life due to systemic dysfunction in metabolic homeostasis and various factors related to β‐cell inflammation. Interestingly, recent studies have proposed that intra‐islet expression of inflammatory cytokines, particularly interleukin (IL)‐1β, contributes to ...
Masahiro Yoda, Natsumi Nomura, Shoko Yoda, Mao Kagotani, Aito Murakami, Fu Namai, Tadashi Fujii, Takumi Tochio, Takashi Sato, Takeshi Shimosato, Yun Shen   +10 more
wiley   +1 more source

Pro Islet Amyloid Polypeptide (ProIAPP) Immunoreactivity in the Islets of Langerhans [PDF]

Upsala Journal of Medical Sciences, 2000
Islet amyloid is typically found in type 2 diabetes mellitus and is believed to participate in the beta cell deterioration. The islet amyloid fibril consists of the 37-amino-acid islet amyloid polypeptide (IAPP) but its pathogenesis is only partly understood.
G T, Westermark, D F, Steiner, S, Gebre-Medhin, U, Engström, P, Westermark   +4 more
openaire   +2 more sources

Structural and Functional Versatility of the Amyloidogenic Non‐Amidated Variant of the Antimicrobial Peptide Citropin 1.3

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Citropin 1.3 is an antimicrobial peptide derived from amphibians that forms amyloid structures. Here, the structural and functional properties of citropin 1.3 are characterized. Using high‐resolution imaging approaches, a variety of canonical and undescribed fibril morphologies are identified.
Fabio Strati, Mariana Pigozzi Cali, Yehudi Bloch, Siavash Mostafavi, Jim Monistrol, Aleksandr Golubev, Bader Rayan, Emil Gustavsson, Meytal Landau   +8 more
wiley   +1 more source

RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes

Molecular Metabolism
Objective: Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 diabetes (T2D), but the mechanisms that underlie this process are incompletely ...
Noyonika Mukherjee, Christopher J. Contreras, Li Lin, Kaitlyn A. Colglazier, Egan G. Mather, Michael A. Kalwat, Nathalie Esser, Steven E. Kahn, Andrew T. Templin   +8 more
doaj   +1 more source

Porcine islet amyloid polypeptide fragments are refractory to amyloid formation

FEBS Letters, 2010
Of 10 variation sites between sequences of amyloid-resistant porcine islet amyloid polypeptide (pIAPP) and amyloid-prone human IAPP (hIAPP), seven locate within residues 17-29, the most amyloidogenic fragment within hIAPP. To investigate how these variations affect amyloidogenicity, 26 IAPP(17-29) or IAPP(20-29) variants were synthesized and their ...
Zhang, Xin, Cheng, Biao, Gong, Hao, Li, Chuanzhou, Chen, Hong, Zheng, Ling, Huang, Kun   +6 more
openaire   +3 more sources

Multiscale Construction, Evaluation, and Application of Organoids

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Organoids are pivotal models with transformative biomedical potential. A comprehensive multi‐scale perspective is presented, encompassing dual‐scale construction, four‐dimensional evaluation, triple‐point application, and an analysis of the current challenges faced by organoid technology, aiming to advance organoid research and its biomedical ...
Wanting Ma, Zhenglin Dong, Zhu'anzhen Zheng, Long Bai, Xingcai Zhang, Jiacan Su   +5 more
wiley   +1 more source

Single‐cell spatial transcriptomics reveals shared transcriptional responses to amyloid proximity in Alzheimer's disease and type 2 diabetes

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background The presence of amyloid pathology can have a profound effect on the surrounding cellular neighborhood. While this impact has been mainly investigated for amyloid plaques in the context of Alzheimer's disease (AD), other forms of amyloid deposits can also be found in the brain and in other organs.
Roy Lardenoije, Angela R. S. Kruse, Lukasz G. Migas, Claire F. Scott, Cody Marshall, Morad C. Malek, Adel Eskaros, Thai Pham, Kristie Aamodt, Madeline Colley, Melissa A. Farrow, Raf Van de Plas, Alvin C. Powers, Matthew Schrag, Jeffrey M. Spraggins, Joana P. Gonçalves   +15 more
wiley   +1 more source

Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway

Frontiers in Pharmacology, 2019
The human islet amyloid polypeptide (hIAPP), the major component of islet amyloid deposition, is one of the amyloidogenic peptides and has been associated with β cell loss and dysfunction in type 2 diabetes (T2D).
Jianzhen Lin, Ao Jiao, Ao Jiao, Wu Lv, Chengshuo Zhang, Yue Shi, Zhaoming Yang, Ning Sun, Xiaohang Li, Jialin Zhang   +9 more
doaj   +1 more source

Diabetes Mellitus and Reprogrammed Glucose Metabolism in Pancreatic Cancer: Features for Clinical Translation [PDF]

, 2016
The reprogrammed metabolism of cancer cells underlies the shift of glucose energetics from the highly efficient oxidative phosphorylation to the less efficient aerobic glycolysis, the Warburg effect.
BASSO, DANIELA, Fogar, Paola, PADOAN, ANDREA, PLEBANI, MARIO, ZAMBON, CARLO-FEDERICO   +4 more
core  

Loss of perlecan heparan sulfate glycosaminoglycans lowers body weight and decreases islet amyloid deposition in human islet amyloid polypeptide transgenic mice.

Protein engineering, design & selection : PEDS, 2019
Islet amyloid is a pathologic feature of type 2 diabetes (T2D) that is associated with β-cell loss and dysfunction. These amyloid deposits form via aggregation of the β-cell secretory product islet amyloid polypeptide (IAPP) and contain other molecules ...
Andrew T. Templin, Mahnaz Mellati, R. Soininen, Meghan F. Hogan, N. Esser, J. J. Castillo, S. Zraika, S. Kahn, R. Hull   +8 more
semanticscholar   +1 more source