Results 131 to 140 of about 6,150 (181)

The islet tissue plasminogen activator/plasmin system is upregulated with human islet amyloid polypeptide aggregation and protects beta cells from aggregation-induced toxicity. [PDF]

Diabetologia
Esser N, Hogan MF, Templin AT, Akter R, Fountaine BS, Castillo JJ, El-Osta A, El-Osta A, Manathunga L, Zhyvoloup A, Raleigh DP, Zraika S, Hull RL, Kahn SE.   +13 more
europepmc   +1 more source

Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA _<i>A</i> receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells. [PDF]

Front Cell Neurosci
Netsyk O, Korol SV, Westermark GT, Birnir B, Jin Z.   +4 more
europepmc   +1 more source

Non-fibril form but not fibril form of human islet amyloid polypeptide 8-20 changes brain functions in mice. [PDF]

PLoS One
Suginoma H, Owada R, Katano-Toki A, Mori A, Fujioka J, Nakamura K.   +5 more
europepmc   +1 more source

XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation. [PDF]

Genes Dis
Zhang Y, Lin S, Yao J, Cai W, Chen H, Aierken A, Wang Z, Song W.   +7 more
europepmc   +1 more source

The Inhibition Effect of Epigallocatechin-3-Gallate on the Co-Aggregation of Amyloid-β and Human Islet Amyloid Polypeptide Revealed by Replica Exchange Molecular Dynamics Simulations. [PDF]

Int J Mol Sci
Li X, Zhang Y, Yang Z, Zhang S, Zhang L.
europepmc   +1 more source

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Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

Physiological Reviews, 2011
Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both locally in the islets, where it inhibits insulin and glucagon secretion, and at distant targets.
Per, Westermark, Arne, Andersson, Gunilla T, Westermark   +2 more
openaire   +2 more sources

Islet Amyloid, Islet-Amyloid Polypeptide, and Diabetes Mellitus

New England Journal of Medicine, 1989
Islet-amyloid deposits, which are a common feature of Type II diabetes mellitus, are derived from the polymerization of a putative hormone identified as IAPP. IAPP is synthesized by normal islet beta cells and probably is cosecreted with insulin. Although the physiologic function of IAPP and its role in the pathogenesis of Type II diabetes mellitus are
Franklin H. Epstein, Kenneth H. Johnson, Timothy D. O'Brien, Christer Betsholtz, Per Westermark   +4 more
openaire   +2 more sources

Islet Amyloid Polypeptide and Diabetes

Current Protein & Peptide Science, 2013
Islet amyloid polypeptide (IAPP, amylin) is a 37 amino acid residue hormone expressed mainly by pancreatic islet beta cells and to less extent by some gastrointestinal endocrine cells and by certain regions in central nervous system. In experimental systems a number of different effects have been ascribed to IAPP but the in vivo importance of many of ...
Gunilla T, Westermark, Per, Westermark
openaire   +2 more sources