Results 141 to 150 of about 6,150 (181)
Some of the next articles are maybe not open access.
Regulation of Islet Amyloid Polypeptide in Human Pancreatic Islets
Diabetes, 1993This study investigated the effect of glucose on islet amyloid polypeptide secretion, content, and mRNA synthesis of human pancreatic islets. The release of islet amyloid polypeptide from fresh isolated islets in response to glucose was parallel to that of insulin.
A, Novials +4 more
openaire +2 more sources
Renal Elimination of Islet Amyloid Polypeptide
Biochemical and Biophysical Research Communications, 1997Six healthy volunteers showed significantly higher plasma islet amyloid polypeptide levels following an oral glucose tolerance test compared to fasting levels. The urine IAPP concentration before and after the OGTT was comparable to that in plasma. Reverse phase HPLC and radioimmunoassay analysis of urine samples revealed a single IAPP-immunoreactive ...
A, Leckström +4 more
openaire +2 more sources
Islet amyloid polypeptide and type 2 diabetes
Experimental Gerontology, 2003Type 2 diabetes is associated with progressive beta-cell failure manifest as a decline in insulin secretion and increasing hyperglycemia. A growing body of evidence suggests that beta-cell failure in type 2 diabetes correlates with the formation of pancreatic islet amyloid deposits, indicating that islet amyloid may have an important role in beta-cell ...
Bruce Verchere, Lucy Marzban
exaly +3 more sources
Molecular biology of islet amyloid polypeptide
Diabetes Research and Clinical Practice, 1992We investigated the relationship between non-insulin-dependent diabetes mellitus (NIDDM) and islet amyloid polypeptide (IAPP) gene by restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR)-direct sequencing analysis. Endonuclease BglII and/or PvuII RFLP analysis revealed no positive correlation of IAPP gene with NIDDM.
M, Nishi +7 more
openaire +2 more sources
Islet Amyloid Polypeptide (IAPP) A short review
Acta Oncológica, 1991The islet amyloid polypeptide (IAPP) was originally identified by chemical analysis of the amyloid component in a human pancreatic islet cell tumor. It consists of 37 amino acids and displays about 50% homology with the neuropeptide calcitonin gene-related peptide (CGRP).
E Wilander, M Stridsberg
exaly +3 more sources
Hormone and Metabolic Research, 1997
Islet amyloid polypeptide forms islet amyloid deposits in non-insulin-dependent diabetes mellitus. We have generated transgenic mice which express human islet amyloid polypeptide in their pancreatic beta cells yet do not develop islet amyloid deposits despite producing levels of the amyloidogenic human peptide 2 - 3 fold higher than the native (mouse ...
C B, Verchere +4 more
openaire +2 more sources
Islet amyloid polypeptide forms islet amyloid deposits in non-insulin-dependent diabetes mellitus. We have generated transgenic mice which express human islet amyloid polypeptide in their pancreatic beta cells yet do not develop islet amyloid deposits despite producing levels of the amyloidogenic human peptide 2 - 3 fold higher than the native (mouse ...
C B, Verchere +4 more
openaire +2 more sources
Diabetes, 1993
IAPP, or amylin, is a 37-amino acid peptide that is co-secreted with insulin from the pancreatic β-cells. We have determined the effects of IAPP and the antagonist 8–37 fragment of IAPP on the secretion of insulin from isolated rat islets studied in a perifusion system. Insulin secretion was stimulated by 8 mM glucose and 0.2 μM carbachol. IAPP at 10−7
Z L, Wang +5 more
openaire +2 more sources
IAPP, or amylin, is a 37-amino acid peptide that is co-secreted with insulin from the pancreatic β-cells. We have determined the effects of IAPP and the antagonist 8–37 fragment of IAPP on the secretion of insulin from isolated rat islets studied in a perifusion system. Insulin secretion was stimulated by 8 mM glucose and 0.2 μM carbachol. IAPP at 10−7
Z L, Wang +5 more
openaire +2 more sources
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide
Biopolymers, 2001Insoluble amyloid formation by islet amyloid polypeptide (IAPP) in the islets of Langerhans of the pancreas is a major pathophysiological feature of noninsulin dependent diabetes mellitus (NIDDM) or type II diabetes. Because in vivo formed amyloid colocalizes with areas of cell degeneration and IAPP amyloid aggregates are cytotoxic per se, the process ...
openaire +2 more sources
Structural Characterisation of Islet Amyloid Polypeptide Fibrils
Journal of Molecular Biology, 2004Islet amyloid is found in many patients suffering from type 2 diabetes. Amyloid fibrils found deposited in the pancreatic islets are composed of a 37-residue peptide, known as islet amyloid polypeptide (IAPP) (also known as amylin) and are similar to those found in other amyloid diseases.
O, Sumner Makin, Louise C, Serpell
openaire +2 more sources
Pancreas, 2000
Amyloid derived from the beta-cell product islet amyloid polypeptide (IAPP) has been implicated for a beta-cell lesion in Type II diabetes mellitus. The pathogenesis of islet amyloid is poorly understood, and in addition to an amyloidogenic IAPP molecule and possibly increased concentration of IAPP, other unknown factors seem to be included.
Z, Ma, P, Westermark, G T, Westermark
openaire +2 more sources
Amyloid derived from the beta-cell product islet amyloid polypeptide (IAPP) has been implicated for a beta-cell lesion in Type II diabetes mellitus. The pathogenesis of islet amyloid is poorly understood, and in addition to an amyloidogenic IAPP molecule and possibly increased concentration of IAPP, other unknown factors seem to be included.
Z, Ma, P, Westermark, G T, Westermark
openaire +2 more sources