β-Hairpin Peptide Mimics Decrease Human Islet Amyloid Polypeptide (hIAPP) Aggregation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Amyloid diseases are degenerative pathologies, highly prevalent today because they are closely related to aging, that have in common the erroneous folding of intrinsically disordered proteins (IDPs) which aggregate and lead to cell death. Type 2 Diabetes
Jacopo Lesma +13 more
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Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model [PDF]
Scientific Reports, 2023 Metal homeostasis is tightly regulated in cells and organisms, and its disturbance is frequently observed in some diseases such as neurodegenerative diseases and metabolic disorders.
Ayako Fukunaka +18 more
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O-glycosylated peptides curtail the aggregation and toxicity of human islet amyloid polypeptide [PDF]
Communications BiologyA key pathogenetic pathway of type 2 diabetes (T2D) is pancreatic beta cell failure, losing their capability of producing insulin and regulating blood glucose.
Qian Zhang +9 more
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XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation [PDF]
Genes and DiseasesAs a pathological hallmark of type 2 diabetes mellitus (T2DM), islet amyloid is formed by the aggregation of islet amyloid polypeptide (IAPP). Endoplasmic reticulum (ER) stress interacts with IAPP aggregates and has been implicated in the pathogenesis of
Yun Zhang +7 more
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Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate. [PDF]
PLoS ONE, 2016 Pancreatic amyloid formation by islet amyloid polypeptide (IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta-cells and co-secreted with insulin to maintain glucose homeostasis.
Ingrid C Rulifson +16 more
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3D analysis of human islet amyloid polypeptide crystalline structures in Drosophila melanogaster. [PDF]
PLoS ONE, 2019 Expression of the Alzheimer's disease associated polypeptide Aβ42 and the human polypeptide hormon islet amyloid polypeptide (hIAPP) and the prohormone precursor (hproIAPP) in neurons of Drosophila melanogaster leads to the formation of protein ...
Ling Xie +4 more
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Interaction of Human Resistin with Human Islet Amyloid Polypeptide at Charged Phospholipid Membranes [PDF]
ACS Omega, 2022 Susanne Dogan +4 more
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The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells. [PDF]
PLoS ONE, 2015 Amyloid formation and mitochondrial dysfunction are characteristics of type 2 diabetes. The major peptide constituent of the amyloid deposits in type 2 diabetes is islet amyloid polypeptide (IAPP).
Hanjun Guan +5 more
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SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition
Molecular Metabolism, 2022 Objective: Sorting-related receptor with type A repeats (SORLA) is a neuronal sorting receptor that prevents accumulation of amyloid-beta peptides, the main constituent of senile plaques in Alzheimer disease. Recent transcriptomic studies show that SORLA
Alexis Z.L. Shih +6 more
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Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling. [PDF]
PLoS ONE, 2018 Amyloid formation in the pancreatic islets due to aggregation of human islet amyloid polypeptide (hIAPP) contributes to reduced β-cell mass and function in type 2 diabetes (T2D) and islet transplantation. Protein kinase B (PKB) signaling plays a key role
Yun Zhang +6 more
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