Results 21 to 30 of about 5,646 (167)
Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets
Endocrine Connections, 2017 Islet amyloid and beta cell death in type 2 diabetes are heterogeneous events, where some islets are affected early in the disease process, whereas others remain visibly unaffected.
Sara Ullsten +5 more
doaj +1 more source
Amyloid-Mediated Mechanisms of Membrane Disruption
Biophysica, 2021 Protein aggregation and amyloid formation are pathogenic events underlying the development of an increasingly large number of human diseases named “proteinopathies”.
Michele F. M. Sciacca +2 more
doaj +1 more source
Scientific Reports, 2021 Amyloid deposits in pancreatic islets, mainly formed by human islet amyloid polypeptide (hIAPP) aggregation, have been associated with loss of β-cell mass and function, and are a pathological hallmark of type 2 diabetes (T2D).
Sara de Pablo +9 more
doaj +1 more source
Molecular Metabolism, 2017 Objectives: β-cell dysfunction and apoptosis associated with islet inflammation play a key role in the pathogenesis of type 2 diabetes (T2D). Growing evidence suggests that islet amyloid, formed by aggregation of human islet amyloid polypeptide (hIAPP ...
Queenie Hui +6 more
doaj +1 more source
Amyloids in Site-Specific Autoimmune Reactions and Inflammatory Responses
Frontiers in Immunology, 2020 Amyloid deposition is a histological hallmark of common human disorders including Alzheimer's disease (AD) and type 2 diabetes. Although some reports highlight that amyloid fibrils might activate the innate immunity system via pattern recognition ...
Yan-Mei Huang +14 more
doaj +1 more source
Foldamer-mediated manipulation of a pre-amyloid toxin
Nature Communications, 2016 Intrinsically disordered proteins that form amyloid fibrils are hard to target with traditional therapeutic approaches. Here, the authors report on an oligoquinoline derivative that binds the human islet amyloid polypeptide, stabilising an alpha-helical ...
Sunil Kumar +5 more
doaj +1 more source
Role and Cytotoxicity of Amylin and Protection of Pancreatic Islet β-Cells from Amylin Cytotoxicity
Cells, 2018 Amylin, (or islet amyloid polypeptide; IAPP), a 37-amino acid peptide hormone, is released in response to nutrients, including glucose, lipids or amino acids. Amylin is co-stored and co-secreted with insulin by pancreatic islet β-cells.
Yoshimitsu Kiriyama, Hiromi Nochi
doaj +1 more source
Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation. [PDF]
Proc Natl Acad Sci U S A, 2017 Significance Protein assembly into amyloid fibers underlies such neurodegenerative disorders as Alzheimer’s disease and Parkinson’s disease. Type 2 diabetes (T2D) also involves amyloid formation, although in the pancreas. Because there are no cures for amyloid diseases and T2D is on the rise due to an increasing prevalence of obesity,
Ribeiro D +5 more
europepmc +5 more sources
Pharmaceuticals, 2021 The number of people worldwide suffering from Alzheimer’s disease (AD) and type 2 diabetes (T2D) is on the rise. Amyloid polypeptides are thought to be associated with the onset of both diseases.
Taisei Tanaka +4 more
doaj +1 more source
Frontiers in Pharmacology, 2019 The human islet amyloid polypeptide (hIAPP), the major component of islet amyloid deposition, is one of the amyloidogenic peptides and has been associated with β cell loss and dysfunction in type 2 diabetes (T2D).
Jianzhen Lin +9 more
doaj +1 more source