Results 31 to 40 of about 5,646 (167)

Chaperones ameliorate beta cell dysfunction associated with human islet amyloid polypeptide overexpression. [PDF]

PLoS ONE, 2014
In type 2 diabetes, beta-cell dysfunction is thought to be due to several causes, one being the formation of toxic protein aggregates called islet amyloid, formed by accumulations of misfolded human islet amyloid polypeptide (hIAPP). The process of hIAPP
Lisa Cadavez, Joel Montane, Gema Alcarraz-Vizán, Montse Visa, Laia Vidal-Fàbrega, Joan-Marc Servitja, Anna Novials   +6 more
doaj   +1 more source

Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus

Journal of Diabetes Research, 2016
Human islet amyloid polypeptide (hIAPP) is the major component of the amyloid deposits found in the pancreatic islets of patients with type 2 diabetes mellitus (T2DM).
Lucie Caillon, Anais R. F. Hoffmann, Alexandra Botz, Lucie Khemtemourian   +3 more
doaj   +1 more source

Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation. [PDF]

PLoS ONE, 2011
BACKGROUND: Recent research supports that aggregation of islet amyloid polypeptide (IAPP) leads to cell death and this makes islet amyloid a plausible cause for the reduction of beta cell mass, demonstrated in patients with type 2 diabetes.
Sebastian Wolfgang Schultz, K Peter R Nilsson, Gunilla Torstensdotter Westermark   +2 more
doaj   +1 more source

Interactions of human islet amyloid polypeptide with lipid structure of different curvatures

Theoretical and Applied Mechanics Letters, 2020
: Curvature is one of the most important features of lipid membranes in living cells, which significantly influences the structure of lipid membranes and their interaction with proteins.
Le Mei, Wenhui Shen, Xuwei Wu, Jie Liu, Dechang Li, Baohua Ji   +5 more
doaj   +1 more source

A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models

Nature Communications, 2023
In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose.
Fabian Wirth, Fabrice D. Heitz, Christine Seeger, Ioana Combaluzier, Karin Breu, Heather C. Denroche, Julien Thevenet, Melania Osto, Paolo Arosio, Julie Kerr-Conte, C. Bruce Verchere, François Pattou, Thomas A. Lutz, Marc Y. Donath, Christoph Hock, Roger M. Nitsch, Jan Grimm   +16 more
doaj   +1 more source

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman, Claudio Pedrick, Cara A. Kreck, Ricardo L. Mancera   +3 more
wiley   +1 more source

The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity [PDF]

Amyloid, 2010
Type 2 diabetes involves aberrant misfolding of human islet amyloid polypeptide (h-IAPP) and resultant pancreatic amyloid deposits. Curcumin, a biphenolic small molecule, has offered potential benefits in other protein misfolding diseases, such as Alzheimer's disease.
Marie, Daval, Sahar, Bedrood, Tatyana, Gurlo, Chang-Jiang, Huang, Safia, Costes, Peter C, Butler, Ralf, Langen   +6 more
openaire   +2 more sources

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate

eLife, 2017
Membrane-assisted amyloid formation is implicated in human diseases, and many of the aggregating species accelerate amyloid formation and induce cell death.
Diana C Rodriguez Camargo, Kyle J Korshavn, Alexander Jussupow, Kolio Raltchev, David Goricanec, Markus Fleisch, Riddhiman Sarkar, Kai Xue, Michaela Aichler, Gabriele Mettenleiter, Axel Karl Walch, Carlo Camilloni, Franz Hagn, Bernd Reif, Ayyalusamy Ramamoorthy   +14 more
doaj   +1 more source