Results 51 to 60 of about 5,646 (167)

Antiglycation of Insulin by Selected Six Bioactive Peanut Sprout Stilbenoids and Demonstration of Methylglyoxal‐Mediated Biphasic Insulin Glycation by O‐Phenylenediamine Derivatization

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Graphical abstract demonstrates 6 peanut sprout containing stilbenoids exhibiting varied structure‐activity potency in protection of insulin integrity from glycation mediated by methylglyoxal (MG), glucose and fructose. Meanwhile, MG‐mediated biphasic insulin glycation was evidenced in Tricine SDS‐PAGE analysis and supported by O‐phenylenediamine (OPD)
Po‐Chang Chiu, Shu‐Mei Lin, Yu‐Jang Li, Chih‐Yu Lo, Robin Y.‐Y. Chiou   +4 more
wiley   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes

Molecular Metabolism
Objective: Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 diabetes (T2D), but the mechanisms that underlie this process are incompletely ...
Noyonika Mukherjee, Christopher J. Contreras, Li Lin, Kaitlyn A. Colglazier, Egan G. Mather, Michael A. Kalwat, Nathalie Esser, Steven E. Kahn, Andrew T. Templin   +8 more
doaj   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

Nanoscale Control of Amyloid Self-Assembly Using Protein Phase Transfer by Host-Guest Chemistry

Scientific Reports, 2017
Amyloid fibrils have recently been highlighted for their diverse applications as functional nanomaterials in modern chemistry. However, tight control to obtain a targeted fibril length with low heterogeneity has not been achieved because of the ...
Tae Su Choi, Hong Hee Lee, Young Ho Ko, Kwang Seob Jeong, Kimoon Kim, Hugh I. Kim   +5 more
doaj   +1 more source

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

Molecular Neurodegeneration, 2007
Background Amyloid-related degenerative diseases are associated with the accumulation of misfolded proteins as amyloid fibrils in tissue. In Alzheimer disease (AD), amyloid accumulates in several distinct types of insoluble plaque deposits, intracellular
Rasool Suhail, Thompson Jennifer L, Breydo Leonid, Wu Jessica, Margol Lawrence, Necula Mihaela, Cotman Carl W, Saing Tommy, Sarsoza Floyd, Head Elizabeth, Kayed Rakez, Gurlo Tatyana, Butler Peter, Glabe Charles G   +13 more
doaj   +1 more source

α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice

Scientific Reports, 2020
Type 2 diabetes (T2D), alike Parkinson’s disease (PD), belongs to the group of protein misfolding diseases (PMDs), which share aggregation of misfolded proteins as a hallmark.
Marija Mucibabic, Pär Steneberg, Emmelie Lidh, Jurate Straseviciene, Agnieszka Ziolkowska, Ulf Dahl, Emma Lindahl, Helena Edlund   +7 more
doaj   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, Volume 13, Issue 37, 3 July 2026.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

A Prodrug Approach for Activity‐Based Chemical Modulation toward Multiple Pathological Targets in Alzheimer's Disease

Small, Volume 22, Issue 41, 22 July 2026.
We present a pathology‐responsive, activity‐based prodrug strategy that tackles multiple hallmarks of Alzheimer's disease (AD). Rationally designed BE compounds convert under oxidative stress into redox‐active aminophenols, neutralizing ROS and redirecting both metal‐free and metal‐bound Aβ aggregation.
Jimin Lee, Eunseo Hong, Chanju Na, Yan Li, Jun Go, Ju‐Eun Kim, Hyun‐Hee Seo, Jong‐Min Suh, Jimin Kwak, Young‐Ho Lee, Kyoung‐Shim Kim, Chul‐Ho Lee, Mingeun Kim, Mi Hee Lim   +13 more
wiley   +1 more source

Janus Polymeric Nanorods Inhibit human Amylin Oligomerization and Fibrillation for Potential Type 2 Diabetes Treatment

Small Science, Volume 6, Issue 7, July 2026.
We demonstrate that polymeric Janus nanorods (JNRs) delay both oligomerization and fibrillation of human islet amyloid polypeptide (hIAPP) through high‐affinity and sequence‐specific interactions. JNRs display a β‐hairpin mimetic ligand (LP2) on one face, enabling multivalent binding.
Mathilde Jégo, Sandra Kalem, Irene Antignano, David Siefker, Mingsheng Ji, Julia Kaffy, Lynda Benrabah, Chloé Cayrou, Kawthar Bouchemal, Mélanie Hery, Erwan Nicol, Sandrine Pensec, Jutta Rieger, Claire Smadja, Sandrine Ongeri, Laurent Bouteiller, Olivier Colombani, Myriam Taverna   +17 more
wiley   +1 more source