Results 71 to 80 of about 5,646 (167)

Amylin receptor: a common pathophysiological target in Alzheimer’s Disease and Diabetes Mellitus

Frontiers in Aging Neuroscience, 2013
Amylin (islet amyloid polypeptide) and amyloid beta protein (Abeta), which are deposited within pancreatic islets of diabetics and brains of Alzheimer’s patients respectively, share many biophysical and physiological properties.
Wen eFu, Aarti ePatel, Jack H. Jhamandas
doaj   +1 more source

Fibrillar dimer formation of islet amyloid polypeptides

AIP Advances, 2015
Amyloid deposits of human islet amyloid polypeptide (hIAPP), a 37-residue hormone co-produced with insulin, have been implicated in the development of type 2 diabetes.
Chi-cheng Chiu, Juan J. de Pablo
doaj   +1 more source

A small molecule improves diabetes in mice expressing human islet amyloid polypeptide. [PDF]

Islets, 2023
Bhagat V, Verchere CB.
europepmc   +1 more source

Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mechanisms

Molecular Metabolism
Objectives: Carriers of PAM (peptidylglycine alpha-amidating monooxygenase) coding variant alleles have reduced insulinogenic index, higher risk of developing type 2 diabetes (T2D), and islets from heterozygous carriers of the PAM p.Asp563Gly variant ...
Yi-Chun Chen, Nils E. Bäck, Jenicia Zhen, Lena Xiong, Mitsuhiro Komba, Anna L. Gloyn, Patrick E. MacDonald, Richard E. Mains, Betty A. Eipper, C. Bruce Verchere   +9 more
doaj   +1 more source

The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer's diseases. [PDF]

Diabetol Metab Syndr, 2023
Alrouji M, Al-Kuraishy HM, Al-Gareeb AI, Alexiou A, Papadakis M, Saad HM, Batiha GE.   +6 more
europepmc   +1 more source

On-Pathway Oligomer of Human Islet Amyloid Polypeptide Induced and Stabilized by Mechanical Rotation during Magic Angle Spinning Nuclear Magnetic Resonance. [PDF]

J Phys Chem Lett, 2023
McCalpin SD, Widanage MCD, Fu R, Ramamoorthy A.   +3 more
europepmc   +1 more source

Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus

Clinical Interventions in Aging, 2015
Hye Rin Jeong, Seong Soo A AnDepartment of Bionano Technology, Gachon Medical Research Institute, Gachon University, Gyeonggi-do, Republic of KoreaAbstract: Human islet amyloid polypeptide (h-IAPP) is a peptide hormone that is synthesized and cosecreted ...
Jeong HR, An SSA
doaj  

Fibril elongation by human islet amyloid polypeptide is the main event linking aggregation to membrane damage. [PDF]

BBA Adv, 2023
Elenbaas BOW, Kremsreiter SM, Khemtemourian L, Killian JA, Sinnige T.   +4 more
europepmc   +1 more source

Influence of force field choice on the conformational landscape of rat and human islet amyloid polypeptide. [PDF]

Proteins, 2023
Moore SJ, Deplazes E, Mancera RL.
europepmc   +1 more source

Human Islet Amyloid Polypeptide (hIAPP) Protofibril-Specific Antibodies for Detection and Treatment of Type 2 Diabetes. [PDF]

Adv Sci (Weinh), 2022
Bortoletto AS, Graham WV, Trout G, Bonito-Oliva A, Kazmi MA, Gong J, Weyburne E, Houser BL, Sakmar TP, Parchem RJ.   +9 more
europepmc   +1 more source