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[Islet of Langerhans transplantation].
Annales de chirurgie, 1996Islet of Langerhans transplantation is considered to be the ideal treatment for type I insulin-dependent diabetes. The permanent and adapted insulin secretion obtained by this method ensures prevention or even regression of the degenerative lesions which now constitute the severity of this frequent disease.
K, Boudjema, E, Alexandre
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WHY ARE THE ISLETS OF LANGERHANS ?
The Lancet, 1969Abstract In the course of evolution, endocrine pancreatic tissue has moved away from its origin in the gut and become distributed throughout the exocrine pancreas as the islets of Langerhans. It is suggested that this is not an evolutionary accident, but that high local concentrations of islet hormones play a significant role in the metabolism of the ...
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Factors Influencing Isolation of Islets of Langerhans
Diabetes, 1989More efficient methods of islet isolation must be developed for islet transplantation to become clinically routine. During collagenase dispersal of human pancreas, an amorphous, viscous, gellike material often develops and entraps large numbers of islets, thereby reducing the yield.
G A, Burghen, L R, Murrell
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[Islets of Langerhans transplantation].
Nephrologie & therapeutique, 2007The objective of future therapy of type 1 diabetes is to prevent the development of the chronic complications of the disease, while reducing the constraints imposed by treatment and eliminating the risk of hypoglycaemia. In other words, the aim is to ensure automatic glycaemic control like the normal pancreas. We can then talk about a cure for diabetes.
Alfred, Penfornis +1 more
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Microtubule interactions in islets of Langerhans.
Hormone and metabolic research. Supplement series, 1980Morphologic and functional studies have implicated islet microtubules in the transport of the B-cell secretory product form the endoplasmic reticulum to the peripheral pool of secretory vesicles. The participation of the microtubular apparatus in the insulin release mechanism appears to be mediated through an increased rate of tubulin synthesis and of ...
Pipeleers, D G +3 more
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Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas
Diabetes, 1967P. Lacy, M. Kostianovsky
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Transplantation of islets of Langerhans
Journal of Hepato-Biliary-Pancreatic Surgery, 1994The present study attempts to evaluate the possibility of using cryopreserved pancreatic islets in rats. Insulin-releasing activity was studied for the purpose of clarifying the function of cryopreserved islets. Cryopreserved pancreatic islets were also transplanted into the portal veins of recipient rats.
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Identification of proliferative and mature β-cells in the islets of Langerhans
Nature, 2016Erik Bader +25 more
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Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates
Nature Medicine, 2022Yuanyuan Du, Shu-Sen Wang, Soon Yi Liew
exaly