Results 41 to 50 of about 3,059 (210)

The wider perspective: Barriers and recommendations for transfusion support for patients with sickle cell disease in low‐ and middle‐income countries

British Journal of Haematology, EarlyView.
Globally, sickle cell disease (SCD) is the most common inherited haemoglobinopathy. The highest burden of SCD is encountered in low‐ and middle‐income countries (LMICs), most of which lack the resources to contend with the disease. Blood transfusion remains central to the emergent treatment and prevention of complications of SCD.
Jeremy W. Jacobs, Luiz Amorim, France Pirenne, Claude Tayou, Ijele Adimora, Lydia H. Pecker, Aaron A. R. Tobian, Jeannie Callum, Julie Makani, Mark T. Gladwin, Meghan Delaney, Darrell J. Triulzi, Isaac Odame, Evan M. Bloch   +13 more
wiley   +1 more source

Physiological Aspects of Genetics [PDF]

, 1954
A considerable amount of evidence indicates that desoxyribonucleic acid is capable of duplicating itself, a property also possessed by genes. (By a self-duplicating material, we mean one which plays some essential role in its own production.) Watson ...
Horowitz, N. H., Owen, Ray D.
core   +1 more source

Repeated injection of pooled frozen allogeneic umbilical cord blood mesenchymal stromal cells in 5 flat‐racing horses

Equine Veterinary Education, EarlyView.
Summary Background Tendinopathies in racehorses are challenging to treat, and restoring normal tendon composition remains elusive despite extensive research. Equine multipotent mesenchymal stromal cells (MSC) have shown promise for tendon repair, and various sources of MSC have been described.
A. Merchan Muñoz, N. Coté, T. Koch, S. Mehrpouyan, A. H. Alizadeh, K. A. Russell, G. Monteith, J. Koenig   +7 more
wiley   +1 more source

SEROLOGICAL ANALYSIS OF THYMUS AND SPLEEN GRAFTS [PDF]

, 1968
Thymus and spleen grafts from neonatal C57BL mice were implanted beneath the kidney capsule of (A x C57BL) F1 hybrids. At various intervals after implantation, the grafts were analyzed serologically.
Hurvitz, Dahlia, Schlesinger, Michael
core   +3 more sources

Obstetric and Gynaecological Challenges and Outcomes in Women and Girls With Glanzmann's Thrombasthenia

Haemophilia, EarlyView.
ABSTRACT Introduction Glanzmann's thrombasthenia (GT) is an inherited platelet function disorder that may manifest with significant bleeding symptoms; in women and girls (W&Gs), heavy menstrual bleeding (HMB) is very common. GT in pregnancy is associated with an increased risk of postpartum haemorrhage (PPH).
Deborah Obeng‐Tuudah, Ahmad Tarawah, Melike Ozkan, Rezan Abdul‐Kadir   +3 more
wiley   +1 more source

Pregnancy with anti-PP1Pk antibody managed with prednisolone and low-molecular-weight heparin – A case report and literature review

Case Reports in Women's Health, 2020
The anti-PP1Pk is a rare antibody associated with recurrent miscarriages, mainly in the first half of pregnancy. There seems to be a direct correlation between the antibody titer and risk of miscarriage.
Sara Nascimento, Marta Rodrigues, Manuel Gonçalves Henriques, Fernanda Paixão Duarte, António Barra, Teresa Matos   +5 more
doaj  

Cytotoxic Isoantibodies and Immunologic Enhancement in Mice.

Experimental Biology and Medicine, 1966
Summary1. Cytotoxic isoantibodies and hemagglutinins are stimulated in response to H-2 isoantigenic differences between graft and host in mice. 2. This study offers data correlating cytotoxic isoantibody and immunological enhancement. 3. The mechanism of immunological enhancement has been shown to be associated with peripheral as well as central ...
openaire   +3 more sources

Longitudinal Evaluation of Immunological Biomarkers in Previously Untreated/Minimally Treated Patients With Severe and Moderately Severe Haemophilia A During Exposure to Factor VIII: Results From the HEMFIL Study

Haemophilia, EarlyView.
ABSTRACT Background Haemophilia A (HA) is an inherited bleeding disorder due to Factor VIII (FVIII) deficiency. Treatment with FVIII can activate immune mechanisms, which may lead to inhibitor development. Objectives This study aimed to perform a longitudinal and exploratory analysis of immunological biomarkers during replacement with FVIII concentrate
Márcio Antônio Portugal Santana, Daniel Gonçalves Chaves, Renan Pedra Souza, Leticia Lemos Jardim, Luciana Werneck Zuccherato, Brendon Ayala Silva Santos, Mônica Hermida Cerqueira, Claudia Santos Lorenzato, Vivian Karla Brognoli Franco, Suely Meireles Rezende   +9 more
wiley   +1 more source

Incorrect blood typing and mis‐transfusion due to low‐titer group O whole blood resuscitation

Transfusion, EarlyView.
Abstract Background Resuscitation strategies for massive hemorrhage increasingly involve the use of low‐titer group O whole blood (LTOWB) due to evidence suggesting improved patient outcomes. However, the potential risk of incorrect ABO typing following LTOWB administration, possibly leading to mis‐transfusion, remains insufficiently explored.
Miriam Brown, Deva Sharma, Kaycie Atchison, Bradley M. Dennis, Erika Hall, Angela Mueller, Christine Schaeffer, Jessica E. Schucht, Jill R. Streams, Toufik Tahiri, Garrett S. Booth, Jeremy W. Jacobs   +11 more
wiley   +1 more source

Vesiculation as potential novel pathogenic mechanism in autoimmune hemolytic anemia

Transfusion, EarlyView.
Abstract Background Autoimmune hemolytic anemia (AIHA) is typically mediated by immunoglobulin G (IgG) or immunoglobulin M (IgM) antibodies, and more rarely by immunoglobulin A (IgA). The mechanism of red blood cell (RBC) destruction in IgA‐mediated AIHA is not well understood.
Esther C. W. de Boer, Femke V. M. Mulder, Silvia Neri, Marije Wiskerke ‐ van Stuijvenberg, Janine J. G. Arts, Simon Tol, Boukje Beuger, Matthieu C. J. Bosman, Noortje Thielen, René van der Griend, Claudia C. Folman, Masja de Haas, Robin van Bruggen, Richard B. Pouw, Josephine M. I. Vos   +14 more
wiley   +1 more source