Results 1 to 10 of about 360,449 (344)
Journal of Clinical Oncology, 2020 PURPOSE Ivosidenib is an oral inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme, approved for treatment of IDH1-mutant (mIDH1) acute myeloid leukemia (AML).
C. Dinardo +27 more
semanticscholar +1 more source
2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. [PDF]
PLoS ONE, 2011 Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). Several different amino acid substitutions recur at either IDH1 R132 or IDH2
Genglin Jin +7 more
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Frontiers in Bioengineering and Biotechnology, 2023 Introduction: Systematic gene knockout studies may offer us novel insights on cell metabolism and physiology. Specifically, the lipid accumulation mechanism at the molecular or cellular level is yet to be determined in the oleaginous yeast Y.
Jiang Zhu +9 more
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Scientific Reports, 2021 A unicellular cyanobacterium Synechocystis sp. PCC 6803 possesses a unique tricarboxylic acid (TCA) cycle, wherein the intracellular citrate levels are approximately 1.5–10 times higher than the levels of other TCA cycle metabolite.
Maki Nishii +3 more
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The relative isoform expression levels of isocitrate dehydrogenase in breast cancer: IDH2 is a potential target in MDA-MB-231 cells [PDF]
Korean Journal of Clinical Oncology, 2023 Purpose The isocitrate dehydrogenase (IDH) family plays an essential role in metabolism and energy production. The relative expression levels of IDH isoforms (IDH1, IDH2, and IDH3) have prognostic significance in several malignancies, including breast ...
Shuyu Piao +7 more
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Isocitrate Dehydrogenase Genes [PDF]
Deutsches Ärzteblatt international, 2015 The molecular classification and taxonomy of malignant diseases, such as the one successfully applied and published by The Cancer Genome Atlas Project TCGA (http://cancergenome.nih.gov/) for urinary bladder and colorectal cancer, adenocarcinoma of the stomach, and glioblastoma multiforme, provides the opportunity to define so-called driver mutations ...
openaire +2 more sources
Cancer-Associated Isocitrate Dehydrogenase Mutations [PDF]
The Oncologist, 2012 The role of isocitrate dehydrogenase mutations as a therapeutic target for cancer therapy is examined.
Katharine E, Yen, David P, Schenkein
openaire +2 more sources
Minimizing acetate formation in E. coli fermentations [PDF]
, 2007 Escherichia coli remains the best established production organisms in industrial biotechnology. However, during aerobic fermentation runs at high growth rates, considerable amounts of acetate are accumulated as by-product.
De Maeseneire, Sofie +3 more
core +2 more sources
Nature Communications, 2020 The prognostic and therapeutic relevance of molecular subtypes for the most aggressive isocitrate dehydrogenase 1/2 ( IDH ) wild-type glioblastoma (GBM) is currently limited due to high molecular heterogeneity of the tumors that impedes patient ...
Sejin Oh +24 more
semanticscholar +1 more source
A spatial analysis of physiological changes associated with infection of cotyledons of marrow plants with cucumber mosaic virus [PDF]
, 1996 Changes in host primary metabolism associated with the compatible interaction between cucumber mosaic virus and cotyledons of the marrow plant (Cucurbita pepo L.) have been localized, first by measuring activities of key enzymes in infected and ...
Leegood, R.C. +3 more
core +3 more sources