Results 1 to 10 of about 402,880 (225)
Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
Biomarker Research, 2019 Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to α-ketoglutarate (α-KG) in the tricarboxylic acid (TCA) cycle. IDH mutation produces a neomorphic enzyme, which can lead to the abnormal accumulation of R-2-HG and ...
Xiaoyan Liu, Yuping Gong
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Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics
Frontiers in Oncology, 2019 The identification of heterozygous neomorphic isocitrate dehydrogenase (IDH) mutations across multiple cancer types including both solid and hematologic malignancies has revolutionized our understanding of oncogenesis in these malignancies and the ...
Danielle Golub +13 more
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Isocitrate dehydrogenase mutations in gliomas [PDF]
Neuro-Oncology, 2015 Over the last decade, extraordinary progress has been made in elucidating the underlying genetic causes of gliomas. In 2008, our understanding of glioma genetics was revolutionized when mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) were identified in the vast majority of progressive gliomas and secondary glioblastomas (GBMs).
Matthew S, Waitkus +2 more
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Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH). [PDF]
PLoS Genetics, 2017 DJ-1 is one of the causative genes for early onset familiar Parkinson's disease (PD) and is also considered to influence the pathogenesis of sporadic PD. DJ-1 has various physiological functions which converge on controlling intracellular reactive oxygen
Jinsung Yang +11 more
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Isocitrate dehydrogenase mutations as potential tumour agnostic targets [PDF]
EJC SupplementsThe isocitrate dehydrogenase (IDH) family of proteins comprises three important metabolic enzymes that convert isocitrate to alpha ketoglutarate (α-KG) via oxidative decarboxylation.
Teresa Macarulla +3 more
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protocols.io, 2020 Isocitrate dehydrogenase is an enzyme which converts isocitrate to 2-oxoglutarate in the TCA cycle. IDH2 uses NADP and IDH3 uses NAD. Our IDH2/3 assay examines accumulation of NADH/NADPH over time.
Kimberly Chapman, Parith Wongkittichote
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Isocitrate dehydrogenase mutations in myeloid malignancies [PDF]
Leukemia, 2016 Alterations to genes involved in cellular metabolism and epigenetic regulation are implicated in the pathogenesis of myeloid malignancies. Recurring mutations in isocitrate dehydrogenase (IDH) genes are detected in approximately 20% of adult patients with acute myeloid leukemia (AML) and 5% of adults with myelodysplastic syndromes (MDS).
Medeiros, B C +5 more
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Expression of IDH1, ATRX, p53 in Diagnosis of Gliomas as Per 2016 WHO Classification [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: The 2016 World Health Organisation (WHO) classification of tumours of the Central Nervous System (WHO CNS 2016 classification) is used to classify diffuse gliomas as astrocytoma, Oligodendroglioma (ODG), glioblastoma which are three ...
Lokesh Kumar +3 more
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The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer
Acta Pharmaceutica Sinica B, 2023 Reprogramming of energy metabolism is one of the basic characteristics of cancer and has been proved to be an important cancer treatment strategy. Isocitrate dehydrogenases (IDHs) are a class of key proteins in energy metabolism, including IDH1, IDH2 ...
Yang Liu +7 more
semanticscholar +1 more source