Results 1 to 10 of about 1,401 (50)

Expression of IDH1, ATRX, p53 in Diagnosis of Gliomas as Per 2016 WHO Classification [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: The 2016 World Health Organisation (WHO) classification of tumours of the Central Nervous System (WHO CNS 2016 classification) is used to classify diffuse gliomas as astrocytoma, Oligodendroglioma (ODG), glioblastoma which are three ...
Lokesh Kumar, Manjiri Karandikar, NS Mani, RC Nimbargi   +3 more
doaj   +1 more source

Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas. [PDF]

PLoS ONE, 2015
Isocitrate dehydrogenase 1 gene mutations are found in most World Health Organization grade II and III gliomas and secondary glioblastomas. Isocitrate dehydrogenase 1 mutations are known to have prognostic value in high-grade gliomas.
Ming-Yang Li, Yin-Yan Wang, Jin-Quan Cai, Chuan-Bao Zhang, Kuan-Yu Wang, Wen Cheng, Yan-Wei Liu, Wei Zhang, Tao Jiang   +8 more
doaj   +1 more source

Pattern of Recurrence of Glioblastoma Versus Grade 4 IDH-Mutant Astrocytoma Following Chemoradiation: A Retrospective Matched-Cohort Analysis

Technology in Cancer Research & Treatment, 2022
Background and Purpose: To quantitatively compare the recurrence patterns of glioblastoma (isocitrate dehydrogenase-wild type) versus grade 4 isocitrate dehydrogenase-mutant astrocytoma (wild type isocitrate dehydrogenase and mutant isocitrate ...
James Stewart PhD, Arjun Sahgal MD, Aimee K M Chan MSc, Hany Soliman MD, Chia-Lin Tseng MD, Jay Detsky MD, PhD, Sten Myrehaug MD, Eshetu G Atenafu MSc, Ali Helmi MD, James Perry MD, Julia Keith MD, Mary Jane Lim-Fat MD, MSc, David G Munoz MD, MSc, Gelareh Zadeh MD, PhD, David B Shultz MD, PhD, Sunit Das MD, PhD, Catherine Coolens PhD, Paula Alcaide-Leon MD, Pejman Jabehdar Maralani MD   +18 more
doaj   +1 more source

Physiological regulation of isocitrate dehydrogenase and the role of 2-oxoglutarate in Prochlorococcus sp. strain PCC 9511. [PDF]

PLoS ONE, 2014
The enzyme isocitrate dehydrogenase (ICDH; EC 1.1.1.42) catalyzes the oxidative decarboxylation of isocitrate, to produce 2-oxoglutarate. The incompleteness of the tricarboxylic acids cycle in marine cyanobacteria confers a special importance to ...
María Agustina Domínguez-Martín, Antonio López-Lozano, Jesús Diez, Guadalupe Gómez-Baena, Oriol Alberto Rangel-Zúñiga, José Manuel García-Fernández   +5 more
doaj   +1 more source

Stochastic Microsensors Based on Carbon Nanotubes for Molecular Recognition of the Isocitrate Dehydrogenases 1 and 2

Nanomaterials, 2022
Two three-dimensional (3D) stochastic microsensors based on immobilization of protoporphyrin IX (PIX) in single-walled carbon nanotubes (SWCNT) and multi-walled carbon nanotubes (MWCNT) decorated with copper (Cu) and gold (Au) nanoparticles were designed
Raluca-Ioana Stefan-van Staden, Catalina Cioates Negut, Sorin Sebastian Gheorghe, Paula Sfirloaga   +3 more
doaj   +1 more source

IDH1(R132H) Immunoexpression in Glioma

Advanced Medical Journal, 2023
Background and objectives: Gliomas are the most common type of primary brain tumors. They result from accumu-- lation of multiple genetic alterations. Isocitrate dehydrogenase 1 mutations are detected in gliomas.
Nyan Saeed Omer, Jalal Ali Jalal , Ava Tahir Ismael   +2 more
doaj   +1 more source

Biochemical adaptation of Weigela florida «Variegata» Bunge A. D. C. microclones to salt- and copper induced stress [PDF]

Сибирский лесной журнал, 2017
Microclones of perennial shrub Weigela florida «Variegata» were prepared, adapted to the conditions of salinity and increased copper ions proportion during the three-step in vitro experiment.
O. A. Zemlyanukhina, V. N. Kalaev, V. S. Voronina, A. T. Eprintsev   +3 more
doaj   +1 more source

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. [PDF]

PLoS ONE, 2011
Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). Several different amino acid substitutions recur at either IDH1 R132 or IDH2
Genglin Jin, Zachary J Reitman, Ivan Spasojevic, Ines Batinic-Haberle, Jian Yang, Oleg Schmidt-Kittler, Darell D Bigner, Hai Yan   +7 more
doaj   +1 more source

Knocking out central metabolism genes to identify new targets and alternating substrates to improve lipid synthesis in Y. lipolytica

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Systematic gene knockout studies may offer us novel insights on cell metabolism and physiology. Specifically, the lipid accumulation mechanism at the molecular or cellular level is yet to be determined in the oleaginous yeast Y.
Jiang Zhu, Yang Gu, Yang Gu, Yijing Yan, Jingbo Ma, Jingbo Ma, Xiaoman Sun, Peng Xu, Peng Xu, Peng Xu   +9 more
doaj   +1 more source

Fluorometric determination of isocitrate dehydrogenase (EC 1.1.1.42; 1; NADP+ dependent) in ruminant milk

Animal, 2022
The enzyme isocitrate dehydrogenase (EC 1.1.1.42; 1; NADP+ dependent) located in the mammary cell cytosol mediates the synthesis of the majority of reducing equivalents for the energetically demanding milk fat and cholesterol synthesis in mammary cell ...
T. Larsen, R. Rupp, N.C. Friggens, J.A.A. Pires   +3 more
doaj   +1 more source