Results 101 to 110 of about 347,846 (181)

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations

Cell Reports Medicine, 2021
Ingvild Hvinden, T. Cadoux-Hudson, C. Schofield, J. Mccullagh   +3 more
semanticscholar   +1 more source

Radiomic model for predicting mutations in the isocitrate dehydrogenase gene in glioblastomas

OncoTarget, 2017
The present study proposed a computer-aided diagnosis system based on radiomic features extracted through magnetic resonance imaging to determine the isocitrate dehydrogenase status in glioblastomas.
K. Hsieh, Cheng-Yu Chen, Chung-Ming Lo
semanticscholar   +1 more source

Adjunctive perampanel for glioma-associated epilepsy

Epilepsy and Behavior Case Reports, 2018
Glioma-associated epilepsy is associated with excessive glutamate signaling. We hypothesized that perampanel, an amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist, would treat glioma-related epilepsy.
Anastasie M. Dunn-Pirio, Sarah Woodring, Eric Lipp, James E. Herndon, II, Patrick Healy, Mallika Weant, Dina Randazzo, Annick Desjardins, Henry S. Friedman, Katherine B. Peters   +9 more
doaj  

Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer?

Biochemical Society Transactions, 2016
In the early 1920s Otto Warburg observed that cancer cells have altered metabolism and from this, posited that mitochondrial dysfunction underpinned the aetiology of cancers.
G. Laurenti, D. Tennant
semanticscholar   +1 more source

How robust are the data in vorasidenib for isocitrate dehydrogenase-1 or isocitrate dehydrogenase-2 mutant low-grade glioma?

Glioma, 2023
Eric T Wong
doaj   +1 more source

The β and γ subunits play distinct functional roles in the α2βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase

Scientific Reports, 2017
Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP.
T. Ma, Yingjie Peng, Wei Huang, Yabing Liu, Jianping Ding   +4 more
semanticscholar   +1 more source

Tricarboxylic acid cycle enzyme activities in a mouse model of methylmalonic aciduria [PDF]

, 2019
Methylmalonic acidemia (MMA) is a propionate pathway disorder caused by dysfunction of the mitochondrial enzyme methylmalonyl-CoA mutase (MMUT). MMUT catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA, an anaplerotic reaction which feeds into ...
Baumgartner, Matthias R, Chapman, Kimberly A, Cunningham, Gary, Forny, Patrick, Pumbo, Elena, Summar, Marshall L, Wongkittichote, Parith   +6 more
core   +1 more source

Peptidase Polymorphism in Natural Populations of the Cocoa Pest, Helopeltis theobromae Miller [PDF]

, 1986
Helopeltis theobromae caught off cocoa plants in Kuala Selangor and off Acalypha plants in Serdang, Selangor, Malaysia were investigated electrophoretically for nine biochemical markers: peptidase, a -glycerophosphate dehydrogenase, 6-phosphogluconate ...
Gan, Yik Yuen, Mohd Saahlan, Rusnah, Muhamad Awang, Rita, Tan, Soon Guan   +3 more
core  

Outcomes of Isocitrate Dehydrogenase Wild Type Glioblastoma after Re-irradiation

Clinical and Translational Radiation Oncology, 2023
Purpose: Glioblastomas (GBM) are the most common malignant primary brain tumors in adults and have a dismal prognosis. Patients frequently suffer from local tumor recurrences, with limited therapeutic options.
Felix Ehret, Josy Wolfgang, Luisa Allwohn, Julia Onken, David Wasilewski, Siyer Roohani, Joachim Oertel, Daniel Zips, David Kaul   +8 more
doaj  

The Key Enzymes of Carbon Metabolism and the Glutathione Antioxidant System Protect Yarrowia lipolytica Yeast Against pH-Induced Stress

Journal of Fungi
In this study, we first thoroughly assayed the response of the key enzymes of energy metabolism and the antioxidant system in Yarrowia lipolytica yeast at extreme pH.
Tatyana I. Rakhmanova, Natalia N. Gessler, Elena P. Isakova, Olga I. Klein, Yulia I. Deryabina, Tatyana N. Popova   +5 more
doaj   +1 more source