Results 111 to 120 of about 344,376 (339)
Microbial Biotechnology, 2019 Summary Pichia pastoris KM71H (MutS) is an efficient producer of hard‐to‐express proteins such as the membrane protein P‐glycoprotein (Pgp), an ATP‐powered efflux pump which is expressed properly, but at very low concentration, using the conventional ...
Wan‐cang Liu +3 more
doaj +1 more source
Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase [PDF]
J Theor Biol 240: 464-474 (2006), 2005 Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to K562 erythroleukemia cells. MAP kinase pathway activation alters the expression of metabolic enzymes in K562 cells.
arxiv +1 more source
Single muscle fiber proteomics reveals unexpected mitochondrial specialization [PDF]
, 2015 Mammalian skeletal muscles are composed of multinucleated cells termed slow or fast fibers according to their contractile and metabolic properties. Here, we developed a high-sensitivity workflow to characterize the proteome of single fibers.
A. S., Deshmukh +8 more
core +1 more source
Annual Review of Biochemistry, 2017 The identification of heterozygous mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) in subsets of cancers, including secondary glioblastoma, acute myeloid leukemia, intrahepatic cholangiocarcinoma, and chondrosarcomas, led to intense ...
L. Dang, Shinsan M. Su
semanticscholar +1 more source
Advanced Science, EarlyView.This study presents a novel approach for intraoperative identification of the IDH1 genotype in glioma patients using a surface‐enhanced Raman scattering (SERS) probe to measure glutathione and hydrogen peroxide. By integrating AI‐driven deep learning algorithms, the method achieves rapid and accurate genotype differentiation, offering the potential to ...
Hang Yin +14 more
wiley +1 more source
Kinetic Model for a Threshold Filter in an Enzymatic System for Bioanalytical and Biocomputing Applications [PDF]
J. Phys. Chem. B 118, 12435-12443 (2014), 2014 A recently experimentally observed biochemical "threshold filtering" mechanism by processes catalyzed by the enzyme malate dehydrogenase is explained in terms of a model that incorporates an unusual mechanism of inhibition of this enzyme that has a reversible mechanism of action.
arxiv +1 more source
Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma. [PDF]
, 2017 Infiltrating low grade gliomas (LGGs) are heterogeneous in their behavior and the strategies used for clinical management are highly variable. A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase 1 and ...
Berger, Mitchel S +12 more
core +1 more source
A Novel Mixed Convolution Transformer Model for the Fast and Accurate Diagnosis of Glioma Subtypes
Advanced Intelligent Systems, EarlyView.The mixed convolutional transformer model represents a novel approach for the accurate and rapid diagnosis of glioma subtypes. This model employs advanced, complex layers and functions, establishing its uniqueness and enhancing its ability to deliver precise outcomes in glioma subtype detection.
S. M. Nuruzzaman Nobel +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.Ein schematischer Überblick über die schädlichen Wirkungen von Ciprofloxacin im Zusammenhang mit mitochondrialer Toxizität. AIFM1 spielt eine Rolle beim MIA40‐vermittelten Import in das IMS und bei der oxidativen Faltung von kernkodierten Proteinen, einschließlich der Untereinheiten der ETC‐Komplexe I und IV.
Till Reinhardt +14 more
wiley +1 more source
Molecular & Cellular Oncology, 2018 The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer.
Prachi Mishra, Wei Tang, Stefan Ambs
doaj +1 more source