Results 111 to 120 of about 41,694 (206)

The Evolution of Pneumocystis jirovecii Pneumonia Prophylaxis for Pediatric Patients With Extracranial Solid Tumors: A Review of Historical Insights and Future Directions

Pediatric Blood &Cancer, Volume 73, Issue 3, March 2026.
ABSTRACT Pneumocystis jirovecii pneumonia (PJP) remains a modern‐day complication for pediatric patients receiving treatment for extracranial solid tumors (ST), highlighting the need for reconsideration of our current approach toward PJP prophylaxis. This critical review aims to evaluate both universal and risk‐stratified approaches to PJP prophylaxis ...
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Isocitrate Dehydrogenase Inhibitor [PDF]

, 2020
openaire   +1 more source

Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice

Aging Cell, Volume 25, Issue 3, March 2026.
The left panel shows cerebral lactate homeostasis in young mice. The middle panel displays accelerated ANLS rates due to FGF21 secretion in aging mice. The right panel demonstrates that lactate uptake and usage inhibition contribute to lactate extracellular accumulation, followed by HCA1‐mediated learning and memory decline in mice.
Keru Ji, Hongde Wei, Ruguang Wang, Yutong Wu, Chen Li, Hongchang Gao, Liangcai Zhao   +6 more
wiley   +1 more source

Inhibitors of mutant isocitrate dehydrogenase for isocitrate dehydrogenase-mutant gliomas: A new standard of care?

Glioma
Emilie Le Rhun, Zhong-ping Chen, Michael Weller   +2 more
doaj   +1 more source

Analysis of Patients With Monocytic and Monocytic‐Like Acute Myeloid Leukemia, Including AML‐M4 and AML‐M5, Treated With Venetoclax Plus Azacitidine

American Journal of Hematology, Volume 101, Issue 3, Page 577-580, March 2026.
Marina Konopleva, Courtney D. DiNardo, Yan Sun, Paul Jung, Sanam Loghavi, Jalaja Potluri, Monique Dail, Brenda Chyla, Daniel A. Pollyea   +8 more
wiley   +1 more source

Targeting MCL‐1 and MAPK overcomes venetoclax resistance in FLT3‐ITD‐positive AML cells harbouring activating PTPN11 (SHP‐2) mutations

British Journal of Haematology, Volume 208, Issue 3, Page 905-915, March 2026.
Summary Venetoclax (VEN)‐based therapies have improved the treatment of acute myeloid leukaemia (AML); however, the emergence of resistance remains a major limitation. Mutations in protein tyrosine phosphatase (PTP) non‐receptor type 11 (PTPN11) and FMS like tyrosine kinase 3 with internal tandem duplication (FLT3‐ITD) are common in resistant patients ...
Maximilian Fleischmann, Ole Hansen, Diana Voigtländer, Julia Bechwar, Lenny‐Joseph Schwietzer, Sanja Bahr, Ulf Schnetzke, Mike Fischer, Florian H. Heidel, Tina M. Schnöder, Jörg P. Müller, Andreas Hochhaus, Sebastian Scholl   +12 more
wiley   +1 more source

Synchronous diagnosis of multicentric glioma with distinct isocitrate dehydrogenase molecular profiles: a case report. [PDF]

CNS Oncol
Mohan AA, Batich K, Wang SJ, López GY, Salacz ME, Peters KB.   +5 more
europepmc   +1 more source

Discrete and cell‐specific hypoxic responses in Arabidopsis roots resolved by single‐nuclei transcriptomics

New Phytologist, Volume 249, Issue 6, Page 2652-2667, March 2026.
Summary With the intensification of unpredictable flooding events because of global warming, there is a need to understand how root cells perceive and respond to oxygen deprivation. The use of high‐throughput single‐nuclei RNA‐sequencing (snRNA‐Seq) allows the examination of gene expression profiles in discrete cell types.
Robert D. Hill, Sean M. Robertson, Abir U. Igamberdiev, Mohammed M. Mira, Olivia Wilkins, Claudio Stasolla   +5 more
wiley   +1 more source

A Case of Multicentric Isocitrate Dehydrogenase-Wildtype Glioblastoma With Divergent Clonal Evolution. [PDF]

Cureus
Shibuya N, Higa N, Akahane T, Yonezawa H, Kirishima M, Tanimoto A, Hanaya R.   +6 more
europepmc   +1 more source

Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings

Plant, Cell &Environment, Volume 49, Issue 3, Page 1598-1616, March 2026.
ABSTRACT Phosphate (Pi) is an essential macronutrient for plant development that is often limited in soil. Plants have evolved dynamic biochemical, physiological and morphological adaptations to cope with Pi deficiency, known as the Pi starvation response (PSR).
Milena A. Smith, Lauren E. Grubb, Kirsten H. Benidickson, Devang Mehta, William C. Plaxton, R. Glen Uhrig   +5 more
wiley   +1 more source