Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas. [PDF]
Gupta P+29 more
europepmc +1 more source
Identification by Mutagenesis of Arginines in the Substrate Binding Site of the Porcine NADP-dependent Isocitrate Dehydrogenase [PDF]
Sambanthamurthy Soundar+2 more
openalex +1 more source
Bovine Endometrium Drives and Responds to Divergence of In Vitro Produced Conceptus Biochemistry
IVD versus IVP bovine conceptus‐endometrial microenvironment. Compared to the in vivo derived (IVD) bovine conceptus, the in vitro produced (IVP) conceptus has a reduced number of transcribed genes, mRNA abundance for genes transcribed and increased expression of inflammatory mediators in response to the endometrium.
Katheryn D. Peterson+14 more
wiley +1 more source
Comprehensive multicentre retrospective analysis for predicting isocitrate dehydrogenase-mutant lower-grade gliomas. [PDF]
Zhao D+12 more
europepmc +1 more source
Locations of the Regulatory Sites for Isocitrate Dehydrogenase Kinase/Phosphatase [PDF]
Stephen P. Miller+5 more
openalex +1 more source
A putative thrazarine biosynthetic gene cluster is discovered in the genome sequence of Streptomyces coerulescens MH802‐fF5. In vivo and in vitro analyses of ThzN, a hydrazine synthetase with cupin and methionyl‐tRNA synthetase‐like domains encoded in the cluster, showed that it synthesizes a key intermediate of thrazarine by catalyzing condensation ...
Yusuke Shikai+4 more
wiley +1 more source
Reciprocal diurnal changes of phosphoenolpyruvate carboxylase expression and cytosolic pyruvate kinase, citrate synthase and NADP‐isocitrate dehydrogenase expression regulate organic acid metabolism during nitrate assimilation in tobacco leaves [PDF]
Wolf‐Rüdiger Scheible+2 more
openalex +1 more source
Abstract Background Patients with recurrent glioblastoma (GBM) have a poor prognosis and limited treatment options. The authors report the efficacy and safety of lenvatinib plus pembrolizumab in participants with recurrent GBM enrolled in the phase 2, multicohort LEAP‐005 study (NCT03797326).
Sun Young Rha+19 more
wiley +1 more source