Results 21 to 30 of about 343,303 (317)

The University of California San Francisco Preoperative Diffuse Glioma MRI (UCSF-PDGM) Dataset [PDF]

Radiology: Artificial Intelligence 4.6 (2022): e220058, 2021
Here we present the University of California San Francisco Preoperative Diffuse Glioma MRI (UCSF-PDGM) dataset. The UCSF-PDGM dataset includes 500 subjects with histopathologically-proven diffuse gliomas who were imaged with a standardized 3 Tesla preoperative brain tumor MRI protocol featuring predominantly 3D imaging, as well as advanced diffusion ...
arxiv   +1 more source

Studying the Phosphorylation of Isocitrate Dehydrogenase in Humans [PDF]

, 2023
Isocitrate dehydrogenase is an important enzyme in the citric acid cycle where it catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate.
Smith, Hannah
core   +3 more sources

Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia

Nature Medicine, 2015
Steven M Chan, Daniel Thomas, Suchita Rastogi   +2 more
exaly   +2 more sources

Ivosidenib in Isocitrate Dehydrogenase 1–Mutated Advanced Glioma

Journal of Clinical Oncology, 2020
PURPOSE Diffuse gliomas are malignant brain tumors that include lower-grade gliomas (LGGs) and glioblastomas. Transformation of low-grade glioma into a higher tumor grade is typically associated with contrast enhancement on magnetic resonance imaging ...
I. Mellinghoff, B. Ellingson, M. Touat, E. Maher, M. I. de la Fuente, M. Holdhoff, G. Cote, H. Burris, F. Janku, R. Young, Raymond Y Huang, Liewen Jiang, S. Choe, Bin Fan, K. Yen, Min Lu, C. Bowden, L. Steelman, S. Pandya, T. Cloughesy, P. Wen   +20 more
semanticscholar   +1 more source

Isocitrate dehydrogenase (IDH) status prediction in histopathology images of gliomas using deep learning

Scientific Reports, 2020
Mutations in isocitrate dehydrogenase genes IDH1 and IDH2 are frequently found in diffuse and anaplastic astrocytic and oligodendroglial tumours as well as in secondary glioblastomas.
Sidong Liu, Zubair Shah, A. Sav, C. Russo, S. Berkovsky, Y. Qian, E. Coiera, A. Di Ieva   +7 more
semanticscholar   +1 more source

Mutant Isocitrate Dehydrogenase 1 Inhibitor Ivosidenib in Combination With Azacitidine for Newly Diagnosed Acute Myeloid Leukemia

Journal of Clinical Oncology, 2020
PURPOSE Ivosidenib is an oral inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme, approved for treatment of IDH1-mutant (mIDH1) acute myeloid leukemia (AML).
C. Dinardo, A. Stein, E. Stein, A. Fathi, O. Frankfurt, A. Schuh, H. Döhner, G. Martinelli, P. Patel, E. Raffoux, P. Tan, A. Zeidan, S. de Botton, H. Kantarjian, R. Stone, M. Frattini, F. Lersch, J. Gong, D. Gianolio, V. Zhang, A. Franovic, Bin Fan, M. Goldwasser, S. Daigle, S. Choe, Bin Wu, T. Winkler, P. Vyas   +27 more
semanticscholar   +1 more source

Biochemical adaptation of Weigela florida «Variegata» Bunge A. D. C. microclones to salt- and copper induced stress [PDF]

Сибирский лесной журнал, 2017
Microclones of perennial shrub Weigela florida «Variegata» were prepared, adapted to the conditions of salinity and increased copper ions proportion during the three-step in vitro experiment.
O. A. Zemlyanukhina, V. N. Kalaev, V. S. Voronina, A. T. Eprintsev   +3 more
doaj   +1 more source

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. [PDF]

PLoS ONE, 2011
Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). Several different amino acid substitutions recur at either IDH1 R132 or IDH2
Genglin Jin, Zachary J Reitman, Ivan Spasojevic, Ines Batinic-Haberle, Jian Yang, Oleg Schmidt-Kittler, Darell D Bigner, Hai Yan   +7 more
doaj   +1 more source

Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications

Biomedicines, 2020
Mutations in isocitrate dehydrogenase (IDH) are commonly observed in lower-grade glioma and secondary glioblastomas. IDH mutants confer a neomorphic enzyme activity that converts α-ketoglutarate to an oncometabolite D-2-hydroxyglutarate, which impacts ...
Yang Liu, F. Lang, F. Chou, K. Zaghloul, Chunzhang Yang   +4 more
semanticscholar   +1 more source

Knocking out central metabolism genes to identify new targets and alternating substrates to improve lipid synthesis in Y. lipolytica

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Systematic gene knockout studies may offer us novel insights on cell metabolism and physiology. Specifically, the lipid accumulation mechanism at the molecular or cellular level is yet to be determined in the oleaginous yeast Y.
Jiang Zhu, Yang Gu, Yang Gu, Yijing Yan, Jingbo Ma, Jingbo Ma, Xiaoman Sun, Peng Xu, Peng Xu, Peng Xu   +9 more
doaj   +1 more source