Results 21 to 30 of about 358,941 (349)

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. [PDF]

PLoS ONE, 2011
Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). Several different amino acid substitutions recur at either IDH1 R132 or IDH2
Genglin Jin, Zachary J Reitman, Ivan Spasojevic, Ines Batinic-Haberle, Jian Yang, Oleg Schmidt-Kittler, Darell D Bigner, Hai Yan   +7 more
doaj   +1 more source

Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities

Nature Communications, 2020
The prognostic and therapeutic relevance of molecular subtypes for the most aggressive isocitrate dehydrogenase 1/2 ( IDH ) wild-type glioblastoma (GBM) is currently limited due to high molecular heterogeneity of the tumors that impedes patient ...
Sejin Oh, Jeonghun Yeom, H. Cho, Ju-Hwa Kim, S. Yoon, Hakhyun Kim, J. Sa, Shinyeong Ju, Hwanho Lee, M. Oh, Wonyeop Lee, Yumi Kwon, Honglan Li, Seunghyuk Choi, Jang Hee Han, Jong-Hee Chang, E. Choi, Ja-Young Kim, N. Her, S. H. Kim, S. Kang, Eunok Paek, D. Nam, Cheolju Lee, Hyun Seok Kim   +24 more
semanticscholar   +1 more source

Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications

Biomedicines, 2020
Mutations in isocitrate dehydrogenase (IDH) are commonly observed in lower-grade glioma and secondary glioblastomas. IDH mutants confer a neomorphic enzyme activity that converts α-ketoglutarate to an oncometabolite D-2-hydroxyglutarate, which impacts ...
Yang Liu, F. Lang, F. Chou, K. Zaghloul, Chunzhang Yang   +4 more
semanticscholar   +1 more source

Knocking out central metabolism genes to identify new targets and alternating substrates to improve lipid synthesis in Y. lipolytica

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Systematic gene knockout studies may offer us novel insights on cell metabolism and physiology. Specifically, the lipid accumulation mechanism at the molecular or cellular level is yet to be determined in the oleaginous yeast Y.
Jiang Zhu, Yang Gu, Yang Gu, Yijing Yan, Jingbo Ma, Jingbo Ma, Xiaoman Sun, Peng Xu, Peng Xu, Peng Xu   +9 more
doaj   +1 more source

Isocitrate dehydrogenase mutations in leukemia [PDF]

Journal of Clinical Investigation, 2013
Recent genome-wide discovery studies have identified a spectrum of mutations in different malignancies and have led to the elucidation of novel pathways that contribute to oncogenic transformation. The discovery of mutations in the genes encoding isocitrate dehydrogenase (IDH) has uncovered a critical role for altered metabolism in oncogenesis, and the
Anna Sophia, McKenney, Ross L, Levine
openaire   +2 more sources

Biochemical elucidation of citrate accumulation in Synechocystis sp. PCC 6803 via kinetic analysis of aconitase

Scientific Reports, 2021
A unicellular cyanobacterium Synechocystis sp. PCC 6803 possesses a unique tricarboxylic acid (TCA) cycle, wherein the intracellular citrate levels are approximately 1.5–10 times higher than the levels of other TCA cycle metabolite.
Maki Nishii, Shoki Ito, Noriaki Katayama, Takashi Osanai   +3 more
doaj   +1 more source

Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue

Experimental and Molecular Medicine, 2020
Isocitrate dehydrogenase 2 (IDH2) is an NADP+-dependent enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate in the mitochondrial matrix, and is critical for the production of NADPH to limit the accumulation of ...
Jae-Ho Lee, Y. Go, Do-Young Kim, S. H. Lee, O. Kim, Y. Jeon, T. Kwon, J. Bae, D. Song, I. Rhyu, I. Lee, M. Shong, Byung-Chul Oh, C. Petucci, Jeen-Woo Park, T. Osborne, S. Im   +16 more
semanticscholar   +1 more source

The relative isoform expression levels of isocitrate dehydrogenase in breast cancer: IDH2 is a potential target in MDA-MB-231 cells [PDF]

Korean Journal of Clinical Oncology, 2023
Purpose The isocitrate dehydrogenase (IDH) family plays an essential role in metabolism and energy production. The relative expression levels of IDH isoforms (IDH1, IDH2, and IDH3) have prognostic significance in several malignancies, including breast ...
Shuyu Piao, Seonhee Kim, Youngduk Seo, Jinsun Lee, Sunhee Jeon, Giang-Huong Vu, Min-Kyung Yeo, Cuk-Seong Kim   +7 more
doaj   +1 more source

Minimizing acetate formation in E. coli fermentations [PDF]

, 2007
Escherichia coli remains the best established production organisms in industrial biotechnology. However, during aerobic fermentation runs at high growth rates, considerable amounts of acetate are accumulated as by-product.
De Maeseneire, Sofie, De Mey, Marjan, Soetaert, Wim, Vandamme, Erick   +3 more
core   +2 more sources

A spatial analysis of physiological changes associated with infection of cotyledons of marrow plants with cucumber mosaic virus [PDF]

, 1996
Changes in host primary metabolism associated with the compatible interaction between cucumber mosaic virus and cotyledons of the marrow plant (Cucurbita pepo L.) have been localized, first by measuring activities of key enzymes in infected and ...
Leegood, R.C., Maule, A.J., Smith, A.M., Tecsi, L.I.   +3 more
core   +3 more sources