The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]
, 2008 Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
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Chemical modification of rat liver cytosolic NADP+-linked isocitrate dehydrogenase by N-ethylmaleimide Evidence for essential sulphydryl groups [PDF]
, 1993 Incubation of rat liver cytosolic isocitrate dehydrogenase with N-ethylmaleimide (NEM) resulted in the inactivation of the enzyme following pseudo-first order kinetics.
Eid Al-Nassar, Khalid +2 more
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Cancer, 2018 Acute myeloid leukemia (AML) cells harboring mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) produce the oncometabolite 2‐hydroxyglutarate (2HG).
A. Brunner +24 more
semanticscholar +1 more source
Molecular & Cellular Oncology, 2018 The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer.
Prachi Mishra, Wei Tang, Stefan Ambs
doaj +1 more source
Studying the Phosphorylation of Isocitrate Dehydrogenase in Humans [PDF]
, 2023 Isocitrate dehydrogenase is an important enzyme in the citric acid cycle where it catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate.
Smith, Hannah
core +3 more sources
Clofibrate elevates enzyme activities of the tricarboxylic acid cycle in rat liver.
Journal of Lipid Research, 1993 Activities of the tricarboxylic acid cycle enzymes were measured in subcellular fractions of liver from rats that had been fed clofibrate for 3 weeks. Large changes in these activities per gram tissue were found in the large particle fraction, which also
C Prager +6 more
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Comparison of Biochemical Activities between High and Low Lipid-Producing Strains of Mucor circinelloides: An Explanation for the High Oleaginicity of Strain WJ11. [PDF]
PLoS ONE, 2015 The oleaginous fungus, Mucor circinelloides, is one of few fungi that produce high amounts of γ-linolenic acid (GLA); however, it usually only produces
Xin Tang +6 more
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Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]
, 2019 York University ...
Bhattacharya, Debasmita, Scimè, Anthony
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Cancer Discovery, 2016 UNLABELLED Intrahepatic cholangiocarcinoma (ICC) is an aggressive liver bile duct malignancy exhibiting frequent isocitrate dehydrogenase (IDH1/IDH2) mutations.
Supriya K. Saha +27 more
semanticscholar +1 more source
Glioblastoma with extracranial parotid, lymph node, and pulmonary metastases: a case report
Radiology Case Reports, 2019 We present a rare case of an isocitrate dehydrogenase-wildtype glioblastoma with histologically proven parotid, cervical lymph node, and lung metastases.
Jeroen Swinnen, MD +4 more
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