World Journal of Surgical Oncology, 2022 Background Maffucci syndrome (MS) is a rare, nonhereditary congenital mesodermal dysplasia characterized by multiple enchondromas and hemangiomas, associated with an increased risk of developing malignant tumors.
Haiyan Lv +10 more
doaj +1 more source
Comparison of Machine Learning Classifiers to Predict Patient Survival and Genetics of GBM: Towards a Standardized Model for Clinical Implementation [PDF]
arXiv, 2021 Radiomic models have been shown to outperform clinical data for outcome prediction in glioblastoma (GBM). However, clinical implementation is limited by lack of parameters standardization. We aimed to compare nine machine learning classifiers, with different optimization parameters, to predict overall survival (OS), isocitrate dehydrogenase (IDH ...
arxiv
Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development. [PDF]
, 2011 Label-free LC-MS/MS-based shot-gun proteomics was used to quantify the differential protein synthesis and metabolite profiling in order to assess metabolic changes during the development of citrus fruits.
Blumwald, Eduardo +8 more
core +3 more sources
Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes
The Scientific World Journal, 2014 Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε ...
Martin Krátký +6 more
doaj +1 more source
Isocitrate Dehydrogenase 1 and 2 Mutations in Pediatric Neuroblastoma Patients
Medeniyet Medical Journal, 2023 Objective: Neuroblastoma is one of the common tumors of childhood. The demonstration of new factors such as isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations will be important in the diagnosis and treatment.
Emre LEVENTOGLU +11 more
doaj +1 more source
Artificial intelligence-based locoregional markers of brain peritumoral microenvironment [PDF]
arXiv, 2022 In malignant primary brain tumors, cancer cells infiltrate into the peritumoral brain structures which results in inevitable recurrence. Quantitative assessment of infiltrative heterogeneity in the peritumoral region, the area where biopsy or resection can be hazardous, is important for clinical decision making.
arxiv
Changes in protein expression in two cholangiocarcinoma cell lines undergoing formation of multicellular tumor spheroids In vitro [PDF]
, 2015 Epithelial-to-Mesenchymal Transition (EMT) is relevant in malignant growth and frequently correlates with worsening disease progression due to its implications in metastases and re- sistance to therapeutic interventions.
Agostinelli, Enzo +15 more
core +2 more sources
CLINICAL STUDIES ON ISOCITRIC DEHYDROGENASE
Nihon Naika Gakkai Zasshi, 1963 イソクエン酸脱水素酵素(ICD)はTPNを補酵素とする脱水素酵素であり肝細胞中の糸粒体に主として認められているが,著者は正常者および各種疾患々者血清中の本酵素活性値を測定した.またこれと並行してトランスアミナーゼ活性値,乳酸脱水素酵素活性値を測定し,各酵素の変動および相関につき觀察した.イソクエン酸脱水素酵素は他の酵素に比べ,肝疾患に特異的であり,特に急性肝炎黄疸前期に著明な活性値上昇を来たし,また肝性昏睡時に中等度の活性値の上昇を来たすことを認めた.慢性肝炎,肝硬変では正常乃至は正常値を多少上廻る活性値を示したが,閉塞性黄疸では一般に上昇は認められず,二次的に肝細胞障害を来たした例には活性値上昇が認められた.その他の疾患ではICD値は正常値を示した ...
openaire +4 more sources
Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas
Journal of Clinical Investigation, 2017 Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 are among the first genetic alterations observed during the development of lower-grade glioma (LGG).
G. Kohanbash +14 more
semanticscholar +1 more source
Chemical modification of rat liver cytosolic NADP+-linked isocitrate dehydrogenase by N-ethylmaleimide Evidence for essential sulphydryl groups [PDF]
, 1993 Incubation of rat liver cytosolic isocitrate dehydrogenase with N-ethylmaleimide (NEM) resulted in the inactivation of the enzyme following pseudo-first order kinetics.
Eid Al-Nassar, Khalid +2 more
core +1 more source