Impact of IDH1 Mutation on Long-Term Survival in Patients with Diffuse Glioma
Central Asian Journal of Medical Sciences, 2019 Objectives: Diffuse brain gliomas are common primary brain tumor associated with a poor prognosis. In this study, we aimed to determine the impact of IDH1 mutation status on long term survival.
Enkhee Ochirjav +3 more
doaj +1 more source
Cognitive functioning in a cohort of high-grade glioma patients
Radiology and Oncology, 2023 High grade gliomas are associated with cognitive problems. The aim of the study was to investigate cognitive functioning in a cohort of patients with high grade glioma, according to isocitrate dehydrogenase (IDH) and methyl guanine methyl transferase ...
Skufca Smrdel Andreja Cirila +6 more
doaj +1 more source
5-hydroxymethylcytosine profiling as an indicator of cellular state [PDF]
, 2013 A Laird is supported by the Medical Research Council Scottish Clinical Pharmacology and Pathology Programme, The Royal College of Surgeons of Edinburgh Robertson’s Trust and The Melville Trust for the Care and Cure of Cancer.
Harrison, David J. +3 more
core +1 more source
Neuro-Oncology, 2016 BACKGROUND The majority of WHO grades II and III gliomas harbor a missense mutation in the metabolic gene isocitrate dehydrogenase (IDH) and accumulate the metabolite R-2-hydroxyglutarate (R-2HG). Prior studies showed that this metabolite can be detected
M. I. de la Fuente +26 more
semanticscholar +1 more source
Isocitrate Dehydrogenase (IDH)1/2 Mutations as Prognostic Markers in Patients With Glioblastomas
Medicine, 2016 The purpose of this study was to perform a meta-analysis examining the association of isocitrate dehydrogenase (IDH)1/2 mutations with overall survival (OS) and progression-free survival (PFS) in patients with glioblastomas.Medline, Cochrane, EMBASE, and
Jun-rui Chen +3 more
semanticscholar +1 more source
Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. [PDF]
, 2018 Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumorigenesis in several cancers. Although significant research has focused on the hypermethylation phenotypes associated with (D)2-hydroxyglutarate (D2HG ...
Badur, Mehmet G +8 more
core
Nuclear mutations affecting mitochondrial structure and function in Chlamydomonas [PDF]
, 1977 Wild type cells of the green alga Chlamydomonas reinhardtii can grow in the in the dark by taking up and respiring exogenously supplied acetate. Obligate photoautotrophic (dark dier, dk) mutants of this alga have been selected which grow at near wild ...
Boynton, J. E. +2 more
core +1 more source
Effects of mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency on fructose-induced obesity in mice [PDF]
, 2018 Obesity prevalence in the United States continues to increase and is associated with health consequences such as type 2 diabetes, hypertension, atherosclerosis, and hyperlipidemia.
Beane, Kaleigh Elizabeth +1 more
core +2 more sources
Pay32p of the Yeast Yarrowia lipolytica Is an Intraperoxisomal Component of the Matrix Protein Translocation Machinery [PDF]
, 1995 Pay mutants of the yeast Yarrowia lipolytica fail to assemble functional peroxisomes. One mutant strain, pay32-1, has abnormally small peroxisomes that are often found in clusters surrounded by membranous material.
Rachubinski, Richard A., +3 more
core +3 more sources
Molecular Psychiatry, 2016 Although evidence for mitochondrial dysfunction in the pathogenesis of bipolar disorder (BD) has been reported, the precise biological basis remains unknown, hampering the search for novel biomarkers.
N. Yoshimi +13 more
semanticscholar +1 more source