Results 81 to 90 of about 68,056 (282)

Predicting medical prognosis in patients with glioblastoma during inpatient rehabilitation using bed mobility function

PM&R, EarlyView.
Abstract Background Determining appropriate suitability and goals for inpatient rehabilitation of patients with glioblastoma, isocitrate dehydrogenase‐wildtype (GBM) requires real‐time prognostic information. Functional measures, such as bed mobility, are standardized scores that can be assessed by members of the care team at the bedside and may aid ...
Tomasz Gruchala, Christopher W. Lewis, Kathryn Abplanalp, Prakash Jayabalan, Theresa L. Walunas, Jodi L. Johnson, Derek A. Wainwright, Rimas V. Lukas, Gayle Spill, Ishan Roy   +9 more
wiley   +1 more source

Noninvasive electrical stimulation enhances the diabetic osseointegration via alleviating mitochondrial damage

VIEW, EarlyView.
A high‐glucose environment induced an imbalance in mitochondrial homeostasis, which resulted in the inhibition of bone tissue regeneration. In this study, we first introduce the exogenous noninvasive direct current electric field (DCEF) strategy for regulating mitochondrial homeostasis and explore its effect on bone regeneration in high‐glucose ...
Dongzong Huang, Rongchen Xu, Changzhen Xu, Peng Xue, Lin Liu, Yiping Fan, Miaoshen Guan, Menglin Luo, Shaoyuan Cui, Xiaoyu Wang, Jin Liu, Chunyu Zhang, Bo Fu, Hua Jiang, Hongbo Li   +14 more
wiley   +1 more source

Control of the citric acid cycle by glyoxylate. The mechanism of inhibition of oxoglutarate dehydrogenase, isocitrate dehydrogenase and aconitate hydratase [PDF]

, 1969
A Adinolfi, Remigio Moratti, S. Olezza, A Ruffo   +3 more
openalex   +1 more source

IDH Genotyping and Glioma Prognosis Research Based on an Interpretable Transformer Learning Framework

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Accurate genotyping and prognosis of glioma patients present significant clinical challenges, often dependent on subjective judgement and insufficient scientific evidence. This study aims to develop a robust, noninvasive preoperative multi‐modal MRI‐based transformer learning model to predict IDH genotyping and glioma prognosis.
Xuan Yu, Yaping Wu, Yan Bai, Nan Meng, Shuting Jin, Qingxia Wu, Lijuan Chen, Ningli Wang, Xiaosheng Song, Guofeng Shen, Meiyun Wang   +10 more
wiley   +1 more source

Cytoplasmic isocitrate dehydrogenase variation within the C3H inbred strain [PDF]

, 1969
Anne McLaren, Andrew Taita
openalex   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

A non‐redox role of the coenzyme in the catalysis of isocitrate dehydrogenase [PDF]

, 1976
Marie F. Carlier, Dominique Pantaloni, Guy Branlant, J.F. Biellmann   +3 more
openalex   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Temperature and enzyme activity in poikilotherms. Isocitrate dehydrogenases in rainbow-trout liver [PDF]

, 1971
Thomas W. Moon, Peter W. Hochachka
openalex   +1 more source