Results 61 to 70 of about 693,247 (202)
IatreiaIntroduction: Gliomas, neoplasms of the central nervous system, are associated with high mortality and morbidity; the IDH1 gene mutation, particularly R132H, is a key diagnostic and prognostic marker in these neoplasms.
Palencia-Palacios, Maribel +6 more
doaj +1 more source
Location and type of isocitrate dehydrogenase mutations influence clinical characteristics and disease outcome of acute myeloid leukemia [PDF]
, 2013 Background: Mutations of isocitrate dehydrogenase 1 and 2 are novel common genetic alterations identified in acute myeloid leukemia. Aims: To investigate the frequency, clinical associations and prognostic effect of isocitrate dehydrogenase 1 and 2 ...
Dolgos, Janos +19 more
core +1 more source
Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis
Advanced Science, EarlyView.Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran +10 more
wiley +1 more source
Scientific Reports, 2021 To explore the value of contrast-enhanced CT texture analysis in predicting isocitrate dehydrogenase (IDH) mutation status of intrahepatic cholangiocarcinomas (ICCs). Institutional review board approved this study.
Yong Zhu +6 more
doaj +1 more source
, 2019 Additional file 1: Figure S1. ROC plots for predicting isocitrate dehydrogenase (IDH) mutation and chromosome 1p/19q codeletion simultaneously. We trained SVM, RF, and AB with feature selection within each fold (10-fold cross validation) to classify ...
Emily Su (341331) +3 more
core +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Sinonasal neuroendocrine carcinoma (SNEC) and sinonasal undifferentiated carcinoma (SNUC) are rare aggressive malignancies with no established prognostic markers. Because features of POU2F3+ small cell lung carcinomas have been identified in both tumors, we evaluated immunostaining for POU2F3, a tuft cell transcription factor, and ...
Nikolina Dioufa +6 more
wiley +1 more source
Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome
Annals of Neurology, EarlyView.Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca +24 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum +5 more
wiley +1 more source
Kinetic Properties of Partially Purified Isocitrate Dehydrogenase [PDF]
, 1973 Within the past few years kinetic studies of NADP+- specific isocitrate dehydrogenase have been conducted extensively following isolation from bacteria, yeast and vertebrates.
Dedhia, Devji
core
The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster. [PDF]
PLoS Genetics, 2013 Dominant mutations in the alpha-B crystallin (CryAB) gene are responsible for a number of inherited human disorders, including cardiomyopathy, skeletal muscle myopathy, and cataracts.
Heng B Xie +8 more
doaj +1 more source