Results 1 to 10 of about 197,005 (375)

l-Isoleucine Administration Alleviates DSS-Induced Colitis by Regulating TLR4/MyD88/NF-κB Pathway in Rats

Frontiers in Immunology, 2022
Inflammatory bowel disease (namely, colitis) severely impairs human health. Isoleucine is reported to regulate immune function (such as the production of immunoreactive substances).
Xiangbing Mao, Xiangbing Mao, Xiangbing Mao, Xiangbing Mao, Rui Sun, Rui Sun, Rui Sun, Rui Sun, Qingxiang Wang, Qingxiang Wang, Qingxiang Wang, Qingxiang Wang, Daiwen Chen, Daiwen Chen, Daiwen Chen, Daiwen Chen, Bing Yu, Bing Yu, Bing Yu, Bing Yu, Jun He, Jun He, Jun He, Jun He, Jie Yu, Jie Yu, Jie Yu, Jie Yu, Junqiu Luo, Junqiu Luo, Junqiu Luo, Junqiu Luo, Yuheng Luo, Yuheng Luo, Yuheng Luo, Yuheng Luo, Hui Yan, Hui Yan, Hui Yan, Hui Yan, Jianping Wang, Jianping Wang, Jianping Wang, Jianping Wang, Huifen Wang, Huifen Wang, Huifen Wang, Huifen Wang, Quyuan Wang, Quyuan Wang, Quyuan Wang, Quyuan Wang   +51 more
doaj   +2 more sources

Isoleucine-to-valine substitutions support cellular physiology during isoleucine deprivation. [PDF]

Nucleic Acids Res
Abstract Aminoacyl-tRNA synthetases (ARSs) couple tRNAs with their corresponding amino acids. While ARSs can bind structurally similar amino acids, extreme specificity is ensured by subsequent editing activity. Yet, we found that upon isoleucine (I) restriction, healthy fibroblasts consistently incorporated valine (V) into proteins at ...
Kok G, Schene IF, Ilcken EF, Alcaraz PS, Mendes MI, Smith DEC, Salomons G, Shehata S, Jans JJM, Maroofian R, Hoek TA, van Es RM, Rehmann H, Nieuwenhuis EES, Vos HR, Fuchs SA.   +15 more
europepmc   +4 more sources

Circulating branched-chain amino acids and the risk of major adverse cardiovascular events in the UK biobank [PDF]

Frontiers in Endocrinology
ObjectiveTo investigate the relationship between circulating branched-chain amino acids (BCAAs) and the risk of major adverse cardiovascular events (MACE) in a national population-based cohort study.MethodsUK Biobank, a prospective study involving 22 ...
Wanwan Sun, Ruilang Lin, Yiming Li, Ye Yao, Bin Lu, Yongfu Yu   +5 more
doaj   +2 more sources

Studies on the the Isoleucine Fermentation

Agricultural and Biological Chemistry, 1962
Accumulation of L-isoleucine and L-valine was studied on 14 genera, 47 species and 110 strains of aerobic bacteria using bacterial type cultures. A large amount of L-isoleucine and a small amount of L-valine accumulated when 1% of DL-α-aminobutyric acid was added to the culture medium.
Masaya Hayashibe, Toshihiko Watanabe
openalex   +4 more sources

Atypical Presentation of IARS1‐Related Disorder: Expanding the Phenotype and Genotype [PDF]

JIMD Reports
Aminoacyl‐tRNA synthetases (ARSs) catalyze the formation of aminoacyl‐tRNA, which is required for protein translation. A growing number of cases are associated with ARS deficiencies.
Parith Wongkittichote, Kira E. Jonatzke, Benjamin T. Hyde, Lance W. Peterson, Mai He, Robert C. McKinstry, Anthony Antonellis, Marwan Shinawi   +7 more
doaj   +2 more sources

The association between dietary branched-chain amino acids and the risk of cardiovascular diseases in Chinese patients with type 2 diabetes: A hospital-based case–control study

Frontiers in Nutrition, 2022
BackgroundPrevious studies showed conflicting evidence on the association between the intake of dietary branched-chain amino acid (BCAA) and the risk of cardiovascular disease (CVD). However, this relationship has not been studied in patients with type 2
Lu Zheng, Jun Cai, Yong-hui Feng, Xin Su, Shi-yun Chen, Jia-zi Liu, Wan-lin Li, Rui-qing Ouyang, Jun-rong Ma, Chen Cheng, Ying-jun Mu, Shi-wen Zhang, Kai-yin He, Fang-fang Zeng, Yan-bin Ye, Yan-bin Ye   +15 more
doaj   +1 more source

Isoleucine Hydroxamate, an Isoleucine Antagonist [PDF]

Journal of Bacteriology, 1971
Isoleucine hydroxamate (Ile·Hdx) was found to inhibit the growth of Serratia marcescens and to antagonize isoleucine. At a low concentration of Ile·Hdx, at which the growth of the wild strain was completely inhibited, the growth of an isoleucine auxotroph was not inhibited in the medium containing a limiting amount ...
Ichiro Chibata, Masaki Sugiura, Saburo Komatsubara, Masahiko Kisumi   +3 more
openaire   +3 more sources

Anomalies in the refinement of isoleucine [PDF]

Acta Crystallographica Section D Biological Crystallography, 2014
A study of isoleucines in protein structures solved using X-ray crystallography revealed a series of systematic trends for the two side-chain torsion angles χ1and χ2dependent on the resolution, secondary structure and refinement software used. The average torsion angles for the nine rotamers were similar in high-resolution structures solved using ...
Berntsen, K.R.M., Vriend, G.
openaire   +4 more sources

Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study

Frontiers in Endocrinology, 2021
BackgroundThis study aimed to explore the association between serum amino acids (AAs) levels and bone mineral density (BMD).MethodsWe performed a two-sample Mendelian randomization (MR) analysis to analyze the associations between the levels of eight AAs
Zhiyong Cui, Zhiyong Cui, Zhiyong Cui, Hui Feng, Hui Feng, Hui Feng, Baichuan He, Baichuan He, Baichuan He, Jinyao He, Jinyao He, Jinyao He, Yun Tian, Yun Tian, Yun Tian   +14 more
doaj   +1 more source

TFIIIR Is an Isoleucine tRNA [PDF]

Molecular and Cellular Biology, 1994
Promoter-specific transcription by silkworm RNA polymerase III is dependent on several transcription factors (TFs) in addition to the polymerase itself. The activities present in silk gland nuclear extracts that are necessary to reconstitute transcription from class III genes in vitro have been resolved into several partially purified components. These
H M Dunstan, Lisa S. Young, Karen U. Sprague   +2 more
openaire   +3 more sources