Results 171 to 180 of about 4,732 (200)

An insight into the therapeutic effects of isoliquiritigenin in breast cancer

Naunyn-Schmiedeberg's Archives of Pharmacology
Breast cancer ranks as the most widespread malignant condition in women, emerging as a primary contributor to mortality. The primary challenges in cancer treatments involve undesirable side effects. Therefore, exploring natural compounds as additional therapy could provide valuable insights. Isoliquiritigenin (ILN), an isoflavonoid featuring a chalcone
Divya Sharma, Mahaveer Dhobi, Viney Lather, Deepti Pandita   +3 more
openaire   +2 more sources

Anti-pseudo-allergy effect of isoliquiritigenin is MRGPRX2-dependent

Immunology Letters, 2018
Mast cell (MC) is the key mediate during allergy accours. The classical MC degranulation pathway is mediated by FcεRI aggregation and varies in strength among subjects, whereas a non-classical but analogous pseudo-allergic way was recently reported to occur via MRGPRX2.
Yajing, Hou, Delu, Che, Pengyu, Ma, Tingting, Zhao, Yingnan, Zeng, Nan, Wang   +5 more
openaire   +2 more sources

Isoliquiritigenin (ISL) and its Formulations: Potential Antitumor Agents

Current Medicinal Chemistry, 2019
Isoliquiritigenin (2’,4’,4-trihydroxychalcone, ISL) is one of the most important chalcone compounds which is mainly derived from licorice root and many other plants. It exhibits a remarkable range of potent biological and pharmacological activities such as antioxidative, antitumor, antiaging, anti-inflammatory, anti-diabetic activities, etc.
Ting-Ting, Zhao, Yu-Qing, Xu, Hui-Min, Hu, Hai-Bin, Gong, Hai-Liang, Zhu   +4 more
openaire   +2 more sources

Glabrene and Isoliquiritigenin as Tyrosinase Inhibitors from Licorice Roots

Journal of Agricultural and Food Chemistry, 2003
Tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. Various dermatological disorders, such as melasama, age spots, and sites of actinic damage, arise from the accumulation of an excessive level of epidermal pigmentation.
Ohad, Nerya, Jacob, Vaya, Ramadan, Musa, Sarit, Izrael, Ruth, Ben-Arie, Snait, Tamir   +5 more
openaire   +2 more sources

Suppression of homodimerization of toll-like receptor 4 by isoliquiritigenin

Phytochemistry, 2010
Toll-like receptors (TLRs) play important inductive roles in innate immune responses for host defense against invading microbial pathogens. Activation of TLR4 by lipopolysaccharide (LPS) induces dimerization of TLR4 and, subsequently, activation of downstream signaling pathways including nuclear factor-kappa B and interferon regulatory factor 3.
Se-Jeong, Park, Hyung-Sun, Youn
openaire   +2 more sources

The Voyage of Natural Chalcone: Isoliquiritigenin

Current Bioactive Compounds
Abstract: This review aims to provide a comprehensive summary of the pharmacological effects of isoliquiritigenin, a natural chalcone. The data was gathered from a variety of research papers published till 2022. The extensive pharmacological features of ISL, including its anti-inflammatory, anti-influenza, anti-tyrosinase, anti-bacterial, anti-sarcoma,
openaire   +1 more source

The Critical Role of Isoliquiritigenin and Glabridin in Anti-metastasis

Journal of Convergence Information Technology, 2011
Our present study focuses on the role of isoliquiritigenin and glabridin in the anti-metastasis effects and the inhibition of the tube-like structure formation of human umbilical vein endothelial cells ECV304. Cell viability assay of murine melanoma cells B16F1 was accomplished by using MTT detection method, the lethality rate was tested by trypan blue
Wang caixia -, Zheng qiusheng -, Wang yishan -, Chen xiaoyu -, Chen na -   +4 more
openaire   +1 more source

Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells

The Journal of Steroid Biochemistry and Molecular Biology, 2002
Licorice root contains chemically diverse compounds that exhibit estrogenic effects in vitro and in vivo. The chalcone isoliquiritigenin (ISL) is a component of licorice extract exhibiting either antitumorigenic activity or estrogen receptor (ER) alpha-dependent growth promoting effects on breast cancer cells.
Maggiolini M., Statti G., Vivacqua A., Gabriele S., Rago V., Loizzo M., Menichini F., Andò S.   +7 more
openaire   +3 more sources

Isoliquiritigenin: a potential drug candidate for the management of erectile dysfunction

Journal of Pharmacy and Pharmacology
Abstract Objective This study aimed to assess the erectogenic properties of isoliquiritigenin taking sildenafil (SDF) as the standard. Methods The binding affinity of isoliquiritigenin (ISL) with the erectile marker proteins ...
Queen Saikia, Kamal Adhikari, Airy Sanjeev, Ajit Hazarika, Kishore Sarma   +4 more
openaire   +2 more sources

Isoliquiritigenin: A New Aldose Reductase Inhibitor from Glycyrrhizae Radix

Planta Medica, 1990
Traditionally in Japan, some kampo medicines (traditional oriental herbal prescriptions) have long been used for the treatment of diabetic neuropathy. We have found that some aldose reductase inhibitors are included among these drugs. We further investigated the components of glycyrrhizae radix, a constituent of some kampo medicines, and isolated six ...
K, Aida, M, Tawata, H, Shindo, T, Onaya, H, Sasaki, T, Yamaguchi, M, Chin, H, Mitsuhashi   +7 more
openaire   +2 more sources