Merging Biocatalysis and Chemocatalysis in Flow: State-of-the-Art and Future Directions for Sustainable Synthesis. [PDF]
Siasiaridis P, Damian M, Mutti FG.
europepmc +1 more source
Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao +8 more
wiley +1 more source
Purified zymogens reveal mechanisms of snake venom metalloproteinase auto-activation. [PDF]
Hall S +17 more
europepmc +1 more source
Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
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Biosynthesis of conjugated linoleic acid: current status and future perspectives. [PDF]
Lin L +5 more
europepmc +1 more source
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi +12 more
wiley +1 more source
Genomic context analysis enables the discovery of an unusual NAD-dependent racemase in phosphonate catabolism. [PDF]
Ruffolo F +8 more
europepmc +1 more source
Edible Insect Allergens: An Emerging Food Safety Challenge
Allergic responses to edible insects arise via two main pathways: cross‐reactivity with homologous arthropod allergens and primary sensitization to edible insect proteins, both leading to IgE‐mediated immune activation. ABSTRACT Edible insects are increasingly promoted as sustainable protein sources; however, their allergenic potential remains a ...
Changqi Liu +5 more
wiley +1 more source
Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival. [PDF]
Xie J +29 more
europepmc +1 more source
Molecular insights and translational opportunities to enhance heat tolerance in rice
Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana +7 more
wiley +1 more source

