Results 121 to 130 of about 475 (151)

Animal Trypanosomiasis: Challenges and Prospects for New Vaccination Strategies. [PDF]

Microorganisms
Pereira SH, Alves FP, Teixeira SMR.
europepmc   +1 more source

[Prothidium and isometamidium as drugs against Trypanosomia brucei in dogs].

Revue d'elevage et de medecine veterinaire des pays tropicaux, 1971
openaire   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Development of a radioimmunoassay for isometamidium

Veterinary Research Communications, 1988
A radioimmunoassay for the trypanocidal drug isometamidium (ISMM) has been developed using antibodies produced in sheep immunized against the drug cross-linked to human serum albumin. With 14C-ISMM as a radioligand, cross-reactivity of the antibodies was determined and found to be less than 3% with pyrithidium, diminazene and quinapyramine and about 13%
L D, Kinabo, J A, Bogan
openaire   +2 more sources

Effect of isometamidium on Trypanosoma congolense infectivity

Veterinary Parasitology, 1991
Isometamidium chloride (Samorin, RMB, England) is a widely used and highly effective trypanocide for the treatment of bovine trypanosomiases. However, the appearance of isometamidium-resistant populations of T. congolense in Africa makes it necessary to develop methods for the rapid and reliable detection of drug resistance in the laboratory. Currently
I A, Sutherland, A, Mounsey, P H, Holmes
openaire   +2 more sources

Acute toxicity of samorin (Isometamidium chloride) in rabbits

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1984
Oral administration of samorin (isometamidium chloride) to rabbits in single oral doses of 6.25, 12.5, 25 and 50 mg/kg produced signs of toxicity which were dose-dependent. These were restlessness, hyperaesthesia, tremors, convulsions and finally death.
B H, Ali, E M, Haroun
openaire   +2 more sources

Pharmacokinetic and histopathological investigations of isometamidium in cattle

Research in Veterinary Science, 1988
The absorption and distribution patterns of the trypanocidal drug isometamidium and its effect on tissues in cattle were characterised. After intramuscular administration of a prophylactic dose of 0.5 mg kg-1 bodyweight, the drug was rapidly detectable in serum at a mean maximum concentration of only 20 ng ml-1 and declined to concentrations of lower ...
L D, Kinabo, J A, Bogan
openaire   +2 more sources

Preliminary pharmacokinetic study of isometamidium chloride in camels

Research in Veterinary Science, 1984
Isometamidium chloride was given to camels at a single intravenous dose rate of 0.5 or 1 mg kg-1 and the plasma drug concentration measured spectrophotometrically at frequent intervals for up to 48 hours. Isometamidium chloride concentrations were found to be 9.8 +/- 0.2 and 8.7 +/- 0.2 micrograms ml-1 half an hour after treatment with 1 and 0.5 mg kg ...
B H, Ali, T, Hassan
openaire   +2 more sources

Monitoring the correct use of isometamidium by farmers and veterinary assistants in Eastern Province of Zambia using the isometamidium-ELISA

Veterinary Parasitology, 2002
A survey to monitor the use of trypanocidal drugs by cattle breeders was conducted in Zambia. Use was made of a questionnaire and of the isometamidium-ELISA technique. One hundred and twenty-two farmers and 50 veterinary assistants were interviewed. The isometamidium-ELISA was used to monitor the isometamidium serum concentration in 72 cattle, 1 week ...
Delespaux, V., Geerts, S., Brandt, J., Elyn, R., Eisler, M.   +4 more
openaire   +3 more sources

Isometamidium in goats: Disposition kinetics, mammary excretion and tissue residues

British Veterinary Journal, 1990
The pharmacokinetics of the antitrypanosomal drug isometamidium were studied in lactating goats after intravenous and intramuscular administration at a dose of 0.5 mg/kg body weight, in a crossover design at an interval of 6 weeks. Following intravenous administration, the half-life of the disappearance of the drug from plasma during the terminal phase
L D, Kinabo, Q A, McKellar
openaire   +2 more sources

The appearance of isometamidium resistant "Trypanosoma congolense" in West Africa

Acta tropica, 1984
The frequent reappearance of patent parasitemia, mainly Trypanosoma congolense, in cattle maintained under isometamidium prophylaxis in the Upper Volta indicated that drug-resistant forms might be appearing. To investigate this possibility, trypanosome stocks were isolated in mice, their isometamidium sensitivity estimated and compared to that of ...
M, Pinder, E, Authie
openaire   +2 more sources