Results 121 to 130 of about 527 (157)

A comparative study of the pharmacokinetics of isometamidium chloride in sheep and goats

Small Ruminant Research, 2004
Abstract A study was carried out to determine and compare the pharmacokinetics of isometamidium in groups of six animals each of sheep and goats treated by intramuscular injection with isometamidium chloride (Samorin ® , Rhone Merieux, Lyon, France) at 0.5 mg/kg body weight.
T W Jones
exaly   +3 more sources

The appearance of isometamidium resistant "Trypanosoma congolense" in West Africa

Acta tropica, 1984
The frequent reappearance of patent parasitemia, mainly Trypanosoma congolense, in cattle maintained under isometamidium prophylaxis in the Upper Volta indicated that drug-resistant forms might be appearing. To investigate this possibility, trypanosome stocks were isolated in mice, their isometamidium sensitivity estimated and compared to that of ...
M, Pinder, E, Authie
openaire   +2 more sources

Concentrations of isometamidium in the sera of cattle challenged with drug-resistant Trypanosoma congolense

Acta Tropica, 1997
The relationship between serum concentrations of the prophylactic trypanocidal drug isometamidium chloride and protection against tsetse challenge with two populations of Trypanosoma congolense was investigated in Boran (Bos indicus) cattle, using an isometamidium-ELISA.
Andrew Peregrine, M C Eisler, P H Holmes   +2 more
exaly   +4 more sources

The Toxic Effect of Intravenous Application of the Trypanocide Isometamidium (Samorin®)

Zentralblatt für Veterinärmedizin Reihe A, 1985
SummaryFor the trypanocide isometamidium chloride (Samorin®, May & Baker) the intramuscular route is recommended by the suppliers but application by this route is followed by local tissue irritation and necrosis. The intravenous administration leads to a dose‐dependent acute systemic toxicity, which can be fatal.
D, Schillinger, S H, Maloo, D, Röttcher
openaire   +2 more sources

A Simple Competitive Enzyme Immunoassay for the Detection of the Trypanocidal Drug Isometamidium

Therapeutic Drug Monitoring, 1996
A new competitive enzyme immunoassay technique has been developed for the determination of concentrations of the trypanocidal drug isometamidium chloride (Samorin) in bovine serum. The method has been shown to be highly repeatable and reproducible, and it has several advantages over previous immunoassay techniques for the drug.
Eisler, MC, Elliott, CT, Holmes, PH
openaire   +2 more sources

Isometamidium in pigs: disposition kinetics, tissue residues and adverse reactions

Research in Veterinary Science, 1991
The disposition and adverse effects of the anti-trypanosomal drug isometamidium in pigs were evaluated. Following intramuscular administration of the drug at doses of 0.5, 15 and 35 mg kg-1, the drug was rapidly absorbed within 15 to 30 minutes to reach maximum plasma concentrations of 12 to 477 (n = 6), 302 to 655 (n = 4) and 1620 (n = 1) ng ml-1 ...
L D, Kinabo, Q A, McKellar, P D, Eckersall   +2 more
openaire   +2 more sources

Susceptibility of dyskinetoplastic Trypanosoma evansi and T. equiperdum to isometamidium chloride

Parasitology Research, 1997
Isometamidium chloride (ISM) is an effective trypanocide with curative and prophylactive activity in husbandry animals. The mode of action of ISM against pathogenic trypanosomes is not fully understood, but there is evidence in the literature that kinetoplastic topoisomerase type II is selectively inhibited by the drug.
Kaminsky R, Schmid C, Lun ZR
openaire   +3 more sources

Isometamidium in goats: Disposition kinetics, mammary excretion and tissue residues

British Veterinary Journal, 1990
The pharmacokinetics of the antitrypanosomal drug isometamidium were studied in lactating goats after intravenous and intramuscular administration at a dose of 0.5 mg/kg body weight, in a crossover design at an interval of 6 weeks. Following intravenous administration, the half-life of the disappearance of the drug from plasma during the terminal phase
L D, Kinabo, Q A, McKellar
openaire   +2 more sources

HPTLC and HPLC determination of isometamidium in the presence of its manufacturing and degradation impurities

Journal of Pharmaceutical and Biomedical Analysis, 1998
The determination of the phenanthridine trypanocide, isometamidium chloride hydrochloride (ISM), in the presence of four process-related and degradation impurities, by RP-HPLC using a Licrospher-60 RP-select B column with a mobile phase composition of acetonitrile/KH2PO4 (PH 3.0, 20 mM) (25:75 v/v) with UV detection at 320 nm, is described.
M H Grant, M H Grant, G G Skellern
exaly   +3 more sources

Influence of atropine on the acute toxicity of isometamidium.

Veterinary and human toxicology, 1993
The effectiveness of atropine in blocking the acute toxic effects of the antitrypanosomal drug isometamidium (ISMM) was evaluated in mice and goats using lethality as the primary index. The median lethal dose (LD50) of ISMM in nonatropinized mice was 45.3 mg/kg bodyweight (SE +/- 5.3 mg/kg bodyweight), whereas the LD50 of ISMM in mice pre-treated with ...
A A, Gimbi, L D, Kinabo
openaire   +1 more source