Results 171 to 180 of about 1,450 (197)

Acute toxicity of samorin (Isometamidium chloride) in rabbits

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1984
Oral administration of samorin (isometamidium chloride) to rabbits in single oral doses of 6.25, 12.5, 25 and 50 mg/kg produced signs of toxicity which were dose-dependent. These were restlessness, hyperaesthesia, tremors, convulsions and finally death.
B H, Ali, E M, Haroun
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Pharmacokinetic and histopathological investigations of isometamidium in cattle

Research in Veterinary Science, 1988
The absorption and distribution patterns of the trypanocidal drug isometamidium and its effect on tissues in cattle were characterised. After intramuscular administration of a prophylactic dose of 0.5 mg kg-1 bodyweight, the drug was rapidly detectable in serum at a mean maximum concentration of only 20 ng ml-1 and declined to concentrations of lower ...
L D, Kinabo, J A, Bogan
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Preliminary pharmacokinetic study of isometamidium chloride in camels

Research in Veterinary Science, 1984
Isometamidium chloride was given to camels at a single intravenous dose rate of 0.5 or 1 mg kg-1 and the plasma drug concentration measured spectrophotometrically at frequent intervals for up to 48 hours. Isometamidium chloride concentrations were found to be 9.8 +/- 0.2 and 8.7 +/- 0.2 micrograms ml-1 half an hour after treatment with 1 and 0.5 mg kg ...
B H, Ali, T, Hassan
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Monitoring the correct use of isometamidium by farmers and veterinary assistants in Eastern Province of Zambia using the isometamidium-ELISA

Veterinary Parasitology, 2002
A survey to monitor the use of trypanocidal drugs by cattle breeders was conducted in Zambia. Use was made of a questionnaire and of the isometamidium-ELISA technique. One hundred and twenty-two farmers and 50 veterinary assistants were interviewed. The isometamidium-ELISA was used to monitor the isometamidium serum concentration in 72 cattle, 1 week ...
Delespaux, V., Geerts, S., Brandt, J., Elyn, R., Eisler, M.   +4 more
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Isometamidium in goats: Disposition kinetics, mammary excretion and tissue residues

British Veterinary Journal, 1990
The pharmacokinetics of the antitrypanosomal drug isometamidium were studied in lactating goats after intravenous and intramuscular administration at a dose of 0.5 mg/kg body weight, in a crossover design at an interval of 6 weeks. Following intravenous administration, the half-life of the disappearance of the drug from plasma during the terminal phase
L D, Kinabo, Q A, McKellar
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The appearance of isometamidium resistant "Trypanosoma congolense" in West Africa

Acta tropica, 1984
The frequent reappearance of patent parasitemia, mainly Trypanosoma congolense, in cattle maintained under isometamidium prophylaxis in the Upper Volta indicated that drug-resistant forms might be appearing. To investigate this possibility, trypanosome stocks were isolated in mice, their isometamidium sensitivity estimated and compared to that of ...
M, Pinder, E, Authie
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Isometamidium in pigs: disposition kinetics, tissue residues and adverse reactions

Research in Veterinary Science, 1991
The disposition and adverse effects of the anti-trypanosomal drug isometamidium in pigs were evaluated. Following intramuscular administration of the drug at doses of 0.5, 15 and 35 mg kg-1, the drug was rapidly absorbed within 15 to 30 minutes to reach maximum plasma concentrations of 12 to 477 (n = 6), 302 to 655 (n = 4) and 1620 (n = 1) ng ml-1 ...
L D, Kinabo, Q A, McKellar, P D, Eckersall   +2 more
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Metabolism of isometamidium in hepatocytes isolated from control and inducer‐treated rats

Journal of Veterinary Pharmacology and Therapeutics, 2006
Little is known about the metabolism and mechanism of action of the trypanocide, isometamidium (ISM), the major drug used for prophylaxis of trypanosomiasis. We have investigated its metabolism and distribution in isolated rat hepatocytes using liquid chromatography‐mass spectrometry and confocal laser scanning microscopy (CLSM).
I, Boibessot, J N A, Tettey, G G, Skellern, D G, Watson, M H, Grant   +4 more
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Susceptibility of dyskinetoplastic Trypanosoma evansi and T. equiperdum to isometamidium chloride

Parasitology Research, 1997
Isometamidium chloride (ISM) is an effective trypanocide with curative and prophylactive activity in husbandry animals. The mode of action of ISM against pathogenic trypanosomes is not fully understood, but there is evidence in the literature that kinetoplastic topoisomerase type II is selectively inhibited by the drug.
R, Kaminsky, C, Schmid, Z R, Lun
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The Toxic Effect of Intravenous Application of the Trypanocide Isometamidium (Samorin®)

Zentralblatt für Veterinärmedizin Reihe A, 1985
SummaryFor the trypanocide isometamidium chloride (Samorin®, May & Baker) the intramuscular route is recommended by the suppliers but application by this route is followed by local tissue irritation and necrosis. The intravenous administration leads to a dose‐dependent acute systemic toxicity, which can be fatal.
D, Schillinger, S H, Maloo, D, Röttcher
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