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Influence of nutrition on trypanosome isometamidium chloride chemoprophylaxis
Animal Research International, 2012Thirty six weaner wistar rats were used to study the effect of protein nutrition on trypanosome isometamidium chloride prophylaxis. Two groups of rats A and B (n = 18 per group) were maintained on 21% and 14.5% crude protein diet respectively for the twenty eight days.
Nnadi, PA, Onyeyili, PA
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Some Effects of the Trypanocidal Drug Isometamidium on Encapsulation in Bovine Carrier Erythrocytes
Biotechnology and Applied Biochemistry, 1988Bovine erythrocyte exposure to isometamidium chloride causes increased osmotic fragility. Control cells tolerated up to 1 mg/ml drug with no effects. Carrier erythrocytes were highly susceptible to drug, with increased osmotic fragility and decreased encapsulation potential of sucrose and inulin.
J R, DeLoach, G G, Wagner
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Veterinary Parasitology, 2007
Chromosome profiles of 10 Trypanosoma (T.) congolense populations with different isometamidium sensitivities were compared using the pulsed field gel electrophoresis technique. The aim was to elucidate whether there was a karyotype pattern specific to eight isometamidium resistant phenotypes.
Francis, Shahada +4 more
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Chromosome profiles of 10 Trypanosoma (T.) congolense populations with different isometamidium sensitivities were compared using the pulsed field gel electrophoresis technique. The aim was to elucidate whether there was a karyotype pattern specific to eight isometamidium resistant phenotypes.
Francis, Shahada +4 more
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A Simple Competitive Enzyme Immunoassay for the Detection of the Trypanocidal Drug Isometamidium
Therapeutic Drug Monitoring, 1996A new competitive enzyme immunoassay technique has been developed for the determination of concentrations of the trypanocidal drug isometamidium chloride (Samorin) in bovine serum. The method has been shown to be highly repeatable and reproducible, and it has several advantages over previous immunoassay techniques for the drug.
Eisler, MC, Elliott, CT, Holmes, PH
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Influence of atropine on the acute toxicity of isometamidium.
Veterinary and human toxicology, 1993The effectiveness of atropine in blocking the acute toxic effects of the antitrypanosomal drug isometamidium (ISMM) was evaluated in mice and goats using lethality as the primary index. The median lethal dose (LD50) of ISMM in nonatropinized mice was 45.3 mg/kg bodyweight (SE +/- 5.3 mg/kg bodyweight), whereas the LD50 of ISMM in mice pre-treated with ...
A A, Gimbi, L D, Kinabo
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Action of isometamidium chloride on the insect vector form of Trypanosoma vivax
Research in Veterinary Science, 1985The effect of isometamidium chloride upon developing and mature Trypanosoma vivax occurring in Glossina palpalis palpalis flies was evaluated. Newly emerged G p palpalis flies were infected with T vivax by allowing them to feed on parasitaemic animals. Two experiments were conducted and in each the flies were divided into two groups.
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The pharmacology of isometamidium
Journal of Veterinary Pharmacology and Therapeutics, 1988L D, Kinabo, J A, Bogan
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Zeitschrift f�r Parasitenkunde Parasitology Research, 1984
The effect of chemoprophylaxis on developing and mature Trypanosoma vivax in Glossina tachinoides and G. palpalis palpalis was evaluated. Newly emerged G. tachinoides and G.p. palpalis flies were infected with T. vivax by allowing them to feed on parasitaemic animals.
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The effect of chemoprophylaxis on developing and mature Trypanosoma vivax in Glossina tachinoides and G. palpalis palpalis was evaluated. Newly emerged G. tachinoides and G.p. palpalis flies were infected with T. vivax by allowing them to feed on parasitaemic animals.
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Transactions of the Royal Society of Tropical Medicine and Hygiene, 1963
J. Hill, J.A. McFadzean
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J. Hill, J.A. McFadzean
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Some observations on the toxicosis of isometamidium chloride (samorin) in camels.
Veterinary and human toxicology, 1986Healthy camels were experimentally infected with Trypanosoma evansi and then treated with isometamidium chloride (samorin) at single intravenous doses of 0.5 or 1.0 mg/kg. Five to 10 min after the drug administration, the camels at both dosages showed lacrimation, salivation, trembling, restlessness, frequent urination and defecation, followed by ...
B H, Ali, T, Hassan
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