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Origins and consequences of kinetoplast loss in trypanosomes
Ridgway M +6 more
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A comparative study of the pharmacokinetics of isometamidium chloride in sheep and goats
Small Ruminant Research, 2004Abstract A study was carried out to determine and compare the pharmacokinetics of isometamidium in groups of six animals each of sheep and goats treated by intramuscular injection with isometamidium chloride (Samorin ® , Rhone Merieux, Lyon, France) at 0.5 mg/kg body weight.
T W Jones
exaly +5 more sources
Journal of Chemotherapy, 1993
The levels of absorption of isometamidium chloride (Samorin) in the stomach and intestine of the rat were determined because of problems usually associated with parenteral administration of the drug. The in situ loop method and in situ recirculation technique were used to determine the absorption of the drug in the stomach and intestine respectively ...
C O, Ogun, K I, Eghianruwa
exaly +3 more sources
The levels of absorption of isometamidium chloride (Samorin) in the stomach and intestine of the rat were determined because of problems usually associated with parenteral administration of the drug. The in situ loop method and in situ recirculation technique were used to determine the absorption of the drug in the stomach and intestine respectively ...
C O, Ogun, K I, Eghianruwa
exaly +3 more sources
Veterinary Parasitology, 2006
In large parts of Africa the control of livestock trypanosomiasis relies on the use of trypanocidal drugs. Resistance against the available compounds is developing rapidly in the trypanosome population. The effect of the development of drug resistance on the fitness of the trypanosome is not well known.
T Marcotty, P Van Den Bossche
exaly +4 more sources
In large parts of Africa the control of livestock trypanosomiasis relies on the use of trypanocidal drugs. Resistance against the available compounds is developing rapidly in the trypanosome population. The effect of the development of drug resistance on the fitness of the trypanosome is not well known.
T Marcotty, P Van Den Bossche
exaly +4 more sources
Acta Tropica, 1995
The duration of prophylaxis provided by isometamidium chloride and homidium bromide, each at a dose rate of 1 mg kg-1 bodyweight, was compared in a 12-month field trial involving groups of 30 zebu cattle in south-west Kenya. The trial took place between February 1990 and February 1991 and included several months of high trypanosome challenge. Cattle in
P Stevenson
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The duration of prophylaxis provided by isometamidium chloride and homidium bromide, each at a dose rate of 1 mg kg-1 bodyweight, was compared in a 12-month field trial involving groups of 30 zebu cattle in south-west Kenya. The trial took place between February 1990 and February 1991 and included several months of high trypanosome challenge. Cattle in
P Stevenson
exaly +3 more sources
Veterinary Parasitology, 2007
Chromosome profiles of 10 Trypanosoma (T.) congolense populations with different isometamidium sensitivities were compared using the pulsed field gel electrophoresis technique. The aim was to elucidate whether there was a karyotype pattern specific to eight isometamidium resistant phenotypes.
Francis Shahada +2 more
exaly +3 more sources
Chromosome profiles of 10 Trypanosoma (T.) congolense populations with different isometamidium sensitivities were compared using the pulsed field gel electrophoresis technique. The aim was to elucidate whether there was a karyotype pattern specific to eight isometamidium resistant phenotypes.
Francis Shahada +2 more
exaly +3 more sources
Acute toxicity of samorin (Isometamidium chloride) in rabbits
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1984Oral administration of samorin (isometamidium chloride) to rabbits in single oral doses of 6.25, 12.5, 25 and 50 mg/kg produced signs of toxicity which were dose-dependent. These were restlessness, hyperaesthesia, tremors, convulsions and finally death.
B H, Ali, E M, Haroun
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Preliminary pharmacokinetic study of isometamidium chloride in camels
Research in Veterinary Science, 1984Isometamidium chloride was given to camels at a single intravenous dose rate of 0.5 or 1 mg kg-1 and the plasma drug concentration measured spectrophotometrically at frequent intervals for up to 48 hours. Isometamidium chloride concentrations were found to be 9.8 +/- 0.2 and 8.7 +/- 0.2 micrograms ml-1 half an hour after treatment with 1 and 0.5 mg kg ...
B H, Ali, T, Hassan
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Susceptibility of dyskinetoplastic Trypanosoma evansi and T. equiperdum to isometamidium chloride
Parasitology Research, 1997Isometamidium chloride (ISM) is an effective trypanocide with curative and prophylactive activity in husbandry animals. The mode of action of ISM against pathogenic trypanosomes is not fully understood, but there is evidence in the literature that kinetoplastic topoisomerase type II is selectively inhibited by the drug.
Kaminsky R, Schmid C, Lun ZR
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