Results 141 to 150 of about 86,651 (264)

The Role of Plasticity in Replay: Stability Through Anti‐Hebbian Rules

Hippocampus, Volume 36, Issue 3, May 2026.
ABSTRACT Hippocampal replay is now considered to be a cornerstone of memory consolidation, yet the synaptic plasticity rules governing its dynamics remain elusive. Under the standard asymmetric Hebbian spike‐timing dependent plasticity (STDP) model, the same spike patterns that promote activity propagation along one direction of sequential activation ...
Lior Baron, Kamran Diba, Asohan Amarasingham   +2 more
wiley   +1 more source

Should TNF inhibitors be avoided in psoriasis patients with latent tuberculosis?

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Fabià Torres‐Betato, Lluís Puig
wiley   +1 more source

Acquired Angioedema Associated With Systemic Lupus Erythematosus Presenting as Acute Abdomen: A Case Report

Journal of General and Family Medicine, Volume 27, Issue 3, May 2026.
ABSTRACT Acquired angioedema (AAE) due to C1 inhibitor deficiency can present as acute abdomen. A 24‐year‐old woman developed severe abdominal pain and bowel wall edema initially suggestive of hereditary angioedema, but genetic testing excluded it. She later manifested fever, arthritis, rash, and serological abnormalities consistent with systemic lupus
Seiji Shiota, Shogo Kodama, Kouichirou Tahara   +2 more
wiley   +1 more source

A model‐based analysis of the CYP2C9 genotype effects on fluconazole inhibition using flurbiprofen, ketoprofen and tolbutamide as probe drugs

British Journal of Pharmacology, Volume 183, Issue 10, Page 2482-2496, May 2026.
Background The activity of CYP2C9, an important drug metabolism enzyme, is subject to the impact of genetic polymorphism. The single nucleotide polymorphism *3 is significantly associated with the increased exposure of CYP2C9 substrates. In addition, metabolic enzyme inhibitors such as fluconazole may also increase the drug exposure of CYP2C9 ...
Shen Cheng, Darcy R. Flora, Mutaz M. Jaber, Allan E. Rettie, Richard C. Brundage, Timothy S. Tracy   +5 more
wiley   +1 more source

Fatal spinal cord compression in a horse with chronic actinobacterial cranial nuchal bursitis

Equine Veterinary Education, Volume 38, Issue 5, Page e235-e242, May 2026.
Summary A 14‐year‐old warmblood gelding was managed for waxing and waning cranial nuchal bursitis for 2 years. Intensive medical and surgical management was not curative, and the patient was subjected to euthanasia after becoming acutely recumbent. Ante‐mortem and post‐mortem next generation sequencing of bursal tissue and post‐mortem conventional PCR ...
H. Mesch, C. Frank, J. B. Daniels, E. Acutt, E. Contino   +4 more
wiley   +1 more source

Structure and Dynamics of Imidazolium in an Ionic Liquid‐PEGDA Iongel via IR, 2D‐IR, and NMR Spectroscopy

ChemPhysChem, Volume 27, Issue 8, 28 April 2026.
Linear and nonlinear vibrational spectroscopies detect tight and loose complexes between imidazolium cations and poly(ethyleneoxide) chains in an iongel. Fourier transform infrared absorption spectroscopy, ultrafast two‐dimensional infrared spectroscopy, nuclear magnetic resonance spectroscopy, and density functional theory calculations show that, in ...
Kallol Mukherjee, Matthew R. Liberatore, Tyler A. Parrack, Sean Garrett‐Roe   +3 more
wiley   +1 more source

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Anticonvulsant Effects of Citronellal, Daidzin, and Phytol, Possibly Through GABAA Receptor and Voltage‐Gated Sodium Channel Interaction Pathways: In Vivo and In Silico Studies

Brain and Behavior, Volume 16, Issue 4, April 2026.
Citronellal, daidzin, and phytol exert significant anticonvulsant effects in a chick seizure model by enhancing GABAergic transmission and blocking voltage‐gated sodium channels, with combination therapies showing enhanced efficacy and a favorable safety profile.
Emon Mia, Md. Anisur Rahman, Md. Nasimul Haque Shipon, Moushumi Afroza Mou, Proma Mandal, Imam Hossen Rakib, Md. Abu Sayeed, Muhammad Torequl Islam, Md. Sakib Al Hasan, Mushtaq Ahmad Ansari   +9 more
wiley   +1 more source

Second Line Treatment Decision as Per Standard of Care or Foundation Medicine in Patients With Locally Advanced or Metastatic Non‐Small Cell Lung Cancer

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background Molecular genetic profiling is crucial for treatment choice in patients with advanced non‐small cell lung cancer (NSCLC). The Lung‐ONE study aimed to determine the clinical utility of comprehensive genomic profile (CGP) tests, such as FoundationOne CDx or FoundationOne Liquid, in guiding second line therapy decisions for advanced ...
Federico Rojo, Enriqueta Felip, Oscar Juan Vidal, Rosario García Campelo, David Aguiar Bujanda, Josefa Terrasa Pons, Rafael López‐Castro, Antonio Calles, Alfredo Paredes Lario, Reyes Bernabé Caro, Isidoro Barneto Aranda, Luis García‐Palacios, Javier De Castro Carpeño   +12 more
wiley   +1 more source