Results 141 to 150 of about 87,478 (258)

Effects of Jobelyn® on Isoniazid-Induced Seizures, Biomarkers of Oxidative Stress and Glutamate Decarboxylase Activity in Mice

Basic and Clinical Neuroscience, 2018
Introduction: Isoniazid-induced seizure, often described as Status Epilepticus (SE), is an emergency condition characterized by repeated convulsive episodes that responds poorly to the currently available anticonvulsant drugs.
Stephen Asehinde, Abayomi Ajayi, Adewale Bakre, Osarume Omorogbe, Adaeze Adebesin, Solomon Umukoro   +5 more
doaj  

Epicutaneous and Drug Provocation Testing in Severe Cutaneous Adverse Reactions: A 20‐Year Single‐Centre Experience

Contact Dermatitis, Volume 94, Issue 6, Page 677-688, June 2026.
This study provides reassuring evidence in favour of early skin testing in patients with SCARs, argues against the necessity of a 6‐month delay, and underscores the pivotal role of oral provocation tests in the safe reintroduction of essential therapies. ABSTRACT Background Identifying and discontinuing the offending drug(s) in severe cutaneous adverse
Zohra Chadli, Khadija Mansour, Ghada Jaouahdou, Manel Ben Belgacem, Yosra Soua, Nadia Ben Fredj, Jameleddine Zili, Haifa Ben Romdhane, Karim Aouam   +8 more
wiley   +1 more source

Rapid Eukaryotic Impedimetric Biosensing of Naproxen and Isoniazid: A Proof-of-Concept for Acute Toxicity Monitoring. [PDF]

Biosensors (Basel)
Štukovnik Z, Perko N, Bren U.
europepmc   +1 more source

Mechanism‐Based Polypharmacy as a Repurposing Strategy: The Case of D‐Cycloserine and Lurasidone

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Modern psychiatric treatment often necessitates polypharmacy, yet combination regimens carry significant risks of metabolic burden and drug–drug interactions. There is growing interest in and clinical acceptance of rational, mechanism‐based drug combinations that are designed around desirable pharmacological properties rather than trial and ...
Avery D. Franzen, John S. Svendsen, Cassidy J. Kline, Susan Q. Shen   +3 more
wiley   +1 more source

Cost-effectiveness of latent tuberculosis infection screening using interferon-gamma release assays among migrants to Japan: a Markov modelling study incorporating social vulnerability and access barriers. [PDF]

BMJ Open
Kowada A.
europepmc   +1 more source

Uneinheitliche Standards beim Tuberkulose‐Screening und der präventiven Tuberkulosetherapie vor Beginn einer systemischen Psoriasistherapie

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 6, Page 737-745, June 2026.
Zusammenfassung Hintergrund und Ziele Die präventive Therapie einer Tuberkulose (TB) vor der Einleitung von Methotrexat (MTX) oder IL‐17/IL‐23/IL‐12/23p40‐Inhibitoren bei latenter Tuberkuloseinfektion (LTBI) wird indirekt durch ein nachweislich erhöhtes TB‐Reaktivierungsrisiko unter TNF‐Inhibitoren gestützt.
Christoph Zeyen, Ruben Heuer, Brit Haecker, Tom Schaberg, Alexander Nast   +4 more
wiley   +1 more source

Therapeutic drug monitoring of first-line anti-tuberculosis drugs: impact of dose modification on plasma drug concentrations in pulmonary and extrapulmonary tuberculosis. [PDF]

J Clin Tuberc Other Mycobact Dis
Alavandar A.
europepmc   +1 more source

Effortful Control and Cortical Brain Structure in 5‐Year‐Old Children: Findings From the FinnBrain Birth Cohort Study

European Journal of Neuroscience, Volume 63, Issue 11, June 2026.
The structural correlates of effortful control in typically developing 5‐year‐olds were found in the left supramarginal/superior parietal region and in the right inferior temporal region. The results differed from those seen in older participants in earlier studies.
Meri Frantti, Jetro J. Tuulari, Saara Nolvi, Elisabeth Nordenswan, Anni Copeland, Venla Kumpulainen, Eero Silver, Harri Merisaari, Ekaterina Saukko, Eeva‐Leena Kataja, Riikka Korja, Linnea Karlsson, Hasse Karlsson, Elmo P. Pulli   +13 more
wiley   +1 more source

Preparation of a chloride salt of covalently modified isoniazid. [PDF]

Acta Crystallogr E Crystallogr Commun
Mahwasane R, Smith MG.
europepmc   +1 more source

Typhoid Toxin of Salmonella enterica Induces ISG15 Responses Mediating Host Cell Survival and Counteracting Intracellular Infection

Molecular Microbiology, Volume 125, Issue 6, Page 475-492, June 2026.
Toxigenic Salmonella enterica exocytose the typhoid toxin during infection causing host cell DNA damage, which activates a Type‐1 Interferon‐like response characterised by interferon‐stimulated gene 15 (ISG15) expression. ISG15 was required for host cell survival during Interferon responses and suppressed intracellular growth of Salmonella. Thus, ISG15
Daniel S. Stark, Michelle King, Angela E. M. Ibler, Salma Srour, Francesca Brown, James Sheffield, Nadia Baseer, Ellen G. Vernon, Yifeng Zhang, Christopher Staples, Lilliana Radoshevich, Daniel Humphreys   +11 more
wiley   +1 more source