Results 61 to 70 of about 97,287 (310)

Herbo-vitamin medicine Livogrit Vital ameliorates isoniazid induced liver injury (IILI) in human liver (HepG2) cells by decreasing isoniazid accumulation and oxidative stress driven hepatotoxicity

BMC Complementary Medicine and Therapies
Background Tuberculosis (TB) is a leading cause of infection related mortality. Isoniazid is one of the frontline drugs for anti-TB therapy. Hepatotoxicity induced by isoniazid is a major cause of drug-discontinuation which may lead to development of ...
Acharya Balkrishna, Vivek Gohel, Meenu Tomer, Rishabh Dev, Anurag Varshney   +4 more
doaj   +1 more source

Association Between the Phenotype and Genotype of Isoniazid Resistance Among Mycobacterium tuberculosis Isolates in Thailand

Infection and Drug Resistance, 2020
Ratchanu Charoenpak, 1 Wichai Santimaleeworagun, 2 Gompol Suwanpimolkul, 3–5 Weerawat Manosuthi, 6 Paweena Kongsanan, 6 Suthidee Petsong, 7 Chankit Puttilerpong 8 1College of Pharmacotherapy Thailand, Nonthaburi, Thailand; 2Department of Pharmacy,
Charoenpak R, Santimaleeworagun W, Suwanpimolkul G, Manosuthi W, Kongsanan P, Petsong S, Puttilerpong C   +6 more
doaj  

Chemoprophylaxis for the prevention of tuberculosis in kidney transplant recipients: A systematic review and meta-analysis

Frontiers in Pharmacology, 2023
Background: A systematic review and meta-analysis was performed to investigate the efficacy and safety of isoniazid (INH) prophylaxis to prevent tuberculosis (TB) infection in kidney transplant recipients (KTRs).Methods: Web of Science, SCOPUS, and ...
Zhihui Yuan, Sheng Chao, Yuan Xu, Yulin Niu   +3 more
doaj   +1 more source

Oxygenated Solanapyrone Analogs From Nigrospora sp. IQ‐064, a Mangrove Associated Fungus

Chemistry &Biodiversity, EarlyView.
ABSTRACT Two new oxygenated solanapyrone analogues, nigrosporapyrone E (1) and nigrosporapyrone F (2), were isolated from Nigrospora sp. strain IQ‐064, a fungus associated with the bark of black mangrove (Avicennia germinans L.), along with seven known compounds.
Carlos A. Fajardo‐Hernández, Ángel Sahid Aguilar‐Colorado, Leslie Maribel Corona‐Cabello, Ingrid Y. Martínez‐Aldino, José Rivera‐Chávez   +4 more
wiley   +1 more source

Antimicrobial effects of folk medicinal plants from the North of Iran against Mycobacterium tuberculosis [PDF]

, 2015
Background: Medicinal plants have been used traditionally in Golestan province (north of Iran), against Mycobacterium tuberculosis or the clinical signs of tuberculosis (TB).
Davoodi, H., Ghaemi, E.A., Ghazisaidi, K., Jahanpour, N., Jahanpour, S., Mazandarani, M., Samet, M.   +6 more
core  

Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain [PDF]

, 2015
The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a
Balloux, Francois, Eldholm, Vegard, Lopez, Beatriz, Monteserin, Johana, Rieux, Adrien, Ritacco, Gloria Viviana, Sobkowiak, Benjamin   +6 more
core   +4 more sources

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Bioprospecting of Labdane‐Type Diterpenes From Austroeupatorium laetevirens: Molecular Networking, Structural Elucidation, and Biological Activity Evaluation

Chemistry &Biodiversity, EarlyView.
ABSTRACT Labdane‐type diterpenes are the main specialized metabolites in the Austroeupatorium genus, known for diverse biological activities. This study employed molecular networking to facilitate the identification of labdanes in Austroeupatorium laetevirens, alongside isolation, structural elucidation, and evaluation of anti‐Mycobacterium ...
Francielli A. P. Valeze, Maria Eduarda V. de Souza, Beatriz P. Moreno, Bianca D. B. Sahm, Andressa L. Ieque, Cleverton S. Fernandes, Regiane B. L. Scodro, Leticia V. Costa‐Lotufo, Marta R. B. do Carmo, Andrea N. L. Batista, João M. Batista Junior, Ernani A. Basso, Maria H. Sarragiotto, Debora C. Baldoqui   +13 more
wiley   +1 more source

Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives

Molecules, 2020
Starting from isoniazid and carboxylic acids as precursors, thirteen new hydrazides and 1,3,4-oxadiazoles of 2-(4-substituted-phenoxymethyl)-benzoic acids were synthesized and characterized by appropriate means. Their biological properties were evaluated
Irina Zarafu, Lilia Matei, Coralia Bleotu, Petre Ionita, Arnaud Tatibouët, Anca Păun, Ioana Nicolau, Anamaria Hanganu, Carmen Limban, Diana Camelia Nuta, Roxana Maria Nemeș, Carmen Cristina Diaconu, Cristiana Radulescu   +12 more
doaj   +1 more source

Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance. [PDF]

, 2015
In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4 ...
Cabrera, JL, Caviedes, L, Chavez, G, Evans, CA, Friedland, JS, Gilman, RH, Kirwan, DE, Lymph Node TB Working Group, Peru, Matos, ED, Moore, DAJ, Rizvi, H, Ticona, E, Ugarte-Gil, C   +12 more
core   +3 more sources