Results 91 to 100 of about 24,191 (225)

Effects of Drug Resistance on the Global Spread of Malaria: A Systematic Literature Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Malaria remains a major health crisis in tropical regions, with Sub‐Saharan Africa bearing the heaviest burden. While insecticide‐treated nets and artemisinin‐based combination therapies (ACTs) have reduced cases, emerging parasite resistance to artemisinin threatens these gains. This review synthesizes evidence on how drug
Ashenafi Woldemichael Woime
wiley   +1 more source

Advances in Organic Aggregates for Biomedical Phototheranostics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
Organic aggregates offer aggregation‐regulated photophysical properties for biomedical phototheranostics, enabling enhanced fluorescence, stabilized room‐temperature phosphorescence, and efficient photoacoustic/photothermal responses. This review highlights molecular design strategies, excited‐state energy modulation, biomedical applications, and ...
Bowen Fu, Yayun Peng, Ting Cai
wiley   +1 more source

Synthesis of 5-bromonaphthalimide derivatives with 3-aminocycloalkanespiro-5-hydantoins [PDF]

BIO Web of Conferences
The present work reports a study on the interaction of 5-bromo-1H,3H-naphtho[1,8-cd]pyran-1,3-dione with various 3-aminocycloalkanespiro-5-hydantoins, aimed at the development of new biologically active compounds.
Marinov Marin, Nikolova Iliana, Kostova Iliana   +2 more
doaj   +1 more source

Avoiding pitfalls when modelling ligands in macromolecular crystallography

Acta Crystallographica Section D, Volume 82, Issue 9, Page 1016-1029, September 2026.
Flawed protein–ligand X‐ray structures can misdirect drug discovery based on PDB‐deposited models. This review uses publicly available PDB examples to highlight potential pitfalls, from absent ligands to incorrect chemistry, and presents a practical validation approach to improve model reliability.The determination of protein–ligand complex structures ...
Oliver S. Smart, Andrew Sharff, Claus Flensburg, Clemens Vonrhein, Gérard Bricogne   +4 more
wiley   +1 more source

isoQUINOLINE DERIVATIVES. PART VII

, 1960
The conversion of the amide (I) into the fully aromatised isoquinoline (II) under the influence of P2O5 in boiling xylene involves decarbonylation.
T. N. GHOSH, BHABATOSH BHATTACHARYA, BINAY KUMAR GHOSH   +2 more
core   +1 more source

3-Methyl-5-phenyl-1-(3-phenylisoquinolin-1-yl)-1H-pyrazole

Acta Crystallographica Section E, 2010
The title compound, C25H19N3, is composed of an aryl-substituted pyrazole ring connected to an aryl-substituted isoquinoline ring system with a dihedral angle of 52.7 (1)° between the pyrazole ring and the isoquinoline ring system. The
F. Nawaz Khan, P. Manivel, Sriramakrishnaswamy Kone, Venkatesha R. Hathwar, Seik Weng Ng   +4 more
doaj   +1 more source

Cell‐Specific Expression and Cellular Compartmental Regulation in Camptothecin Biosynthesis

Plant Biotechnology Journal, Volume 24, Issue 9, Page 5114-5130, September 2026.
ABSTRACT Plant secondary metabolites such as monoterpenoid indole alkaloids (MIAs) show tightly regulated biosynthesis and accumulation in specific organelles of distinct cell types. However, the cell‐specific expression patterns of anticancer MIA camptothecin biosynthetic genes in Ophiorrhiza pumila and the regulatory mechanisms of camptothecin ...
Xiaolong Hao, Yinkai Yang, Tiantian Chen, Xiaoxuan Fan, Yiqing Peng, Qingyan Ruan, Qin Zhou, Fanghao Liu, Jiayi He, Yongpeng Li, Yue Feng, Jiyan Qi, Guoyin Kai   +12 more
wiley   +1 more source

Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid [PDF]

, 2013
Methanol extracts of the roots of B. brevissima and B. parkeriana were examined for antidiabetic and antimicrobial activities. Six compounds i.e berberine, 8-oxo-berberine, dehydrocheilanthifoline, columbamine, jatrorrhizine and glutamic acid were ...
Muhammad Rafiullah Khan, Alexander I. Gray, Ali, Saqib, Almazeb, Muhammad, John Igoli, Khan, M Rafiullah, Syed Qaisar Shah, Ferro, Valerie, Mamoon Ur Rashid, Muhammad Alamzeb, Shah, Syed Qaisar, Carol Clements, Gray, Alexander, Clements, Carol, Valerie A. Ferro, Igoli, John, Saqib Ali, Dima Semaan, Rashid, Mamoon-Ur, Semaan, Dima   +19 more
core   +1 more source

Number and Position of Methoxy Substituents Govern Photophysics and Visible‐Light Photocatalysis in Earth‐Abundant Cu(I) Complexes

ChemSusChem, Volume 19, Issue 16, 27 August 2026.
The number and position of methoxy substituents provide a versatile molecular toolbox for tuning the photophysics and visible‐light photocatalytic performance of heteroleptic Cu(I) photosensitizers. Earth‐abundant Cu(I) photosensitizers are promising systems for visible‐light‐driven photocatalysis, but further design guidelines are required to relate ...
Kurt J. Haseloff, Max Wolf, Katharina Rediger, Christian Kleeberg, Maria Wächtler, Stefanie Tschierlei, Michael Karnahl   +6 more
wiley   +1 more source

Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition

Molecules, 2013
Pyrrolo[2,1-a]isoquinoline derivatives were synthesized by one-pot three-component reactions starting from isoquinoline, 2-bromoacetophenones and different non-symmetrical acetylenic dipolarophiles using 1,2-epoxypropane as solvent.
Marcel Mirel Popa, Denisa Dumitrescu, Emilian Georgescu, Florentina Georgescu, Florea Dumitrascu   +4 more
doaj   +1 more source