Results 81 to 90 of about 24,191 (225)

SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic, Jovana Rajkovic, Radmila Novakovic, Javad Sharifi‐Rad, Daniela Calina   +4 more
wiley   +1 more source

Aminomethylation/hydrogenolysis as an alternative to direct methylation of metalated isoquinolines – a novel total synthesis of the alkaloid 7-hydroxy-6-methoxy-1-methylisoquinoline

Beilstein Journal of Organic Chemistry, 2018
Highly-substituted isoquinolines are important scaffolds in syntheses of natural products and in drug development and hence, effective synthetic approaches are required.
Benedikt C. Melzer, Jan G. Felber, Franz Bracher   +2 more
doaj   +1 more source

Iridium‐Catalyzed Ionic Hydrogenation of Multi‐Aza Heterocycles

Angewandte Chemie, Volume 138, Issue 35, 24 August 2026.
Saturated nitrogen‐containing heterocycles are ubiquitous in bioactive molecules and are thus attractive synthetic targets. A readily accessible cyclometalated iridium(III) complex reduces 14 different aromatic aza heterocycles to (partially)saturated multi aza‐heterocycles enlarging accessible chemical space while displaying high tolerance toward ...
Arthur Despois, Nicolai Cramer
wiley   +2 more sources

Isoxazole–Thiazole Hybrids: Synthesis, Structural Characterisation, Carbonic Anhydrase Inhibition, and Molecular Docking Studies

Molecules
A new series of isoxazole-fused thiazole–oxazole derivatives (11a–n) was rationally designed and synthesised with the aim of developing potent carbonic anhydrase (CA) I and II inhibitors.
Nurcan Berber, Özge Nur Türkeri, Faika Başoğlu, Kubra Çıkrıkcı, Adem Ergün, Nahit Gencer   +5 more
doaj   +1 more source

isoquinoline alkaloid biosynthesis-png

, 2014
unigenes associated with isoquinoline alkaloid ...
Karen Fugate (480954)
core   +1 more source

The First Glycosides with Pyrazolo[3,4-C]isoquinoline Aglycone Moiety. Synthesis and NMR Structure Investigation [PDF]

, 2020
we describe the methods of obtaining N- and O-glycosides with the pyrazolo[3,4-c]isoquinoline as aglycone moiety. O-glycosides are obtained in good yields under phase transfer catalysis.
Vladimir, Kyryanov, Sergej, Sujkov, Andrii, Khairulin, Tatiana, Chupakhina, SERGE, BOGZA, Natalia, Bogdan, Dalila, Bousta, Andriy, Grafov, Olena, Holembiovska   +8 more
core   +2 more sources

Phytochemical Profiling and Evaluation of Antibacterial, Anticancer, Anti‐inflammatory, and Wound‐Healing Activities of Endophytic Fungi Isolated From Atalantia racemosa

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
ABSTRACT Endophytic fungi are recognized as prolific sources of structurally diverse secondary metabolites with significant pharmaceutical potential. In the present study, endophytic fungi were isolated from healthy tissues of Atalantia racemosa (Rutaceae), an ethnomedicinal plant traditionally used for respiratory disorders and blood purification.
Sushma M, Arun Shettar, Joy Hoskeri, Vedamurthy A B   +3 more
wiley   +1 more source

Isoquinoline skeleton synthesis via chelation-assisted C−H activation [PDF]

, 2014
Transition-metal-catalyzed isoquinoline synthesis that profits from the strategy of chelation-assisted C−H activation has flourished over the past decade.
Huang, Zhi-Tang, Zheng, Qi-Yu, He, Ruoyu, Wang, Congyang   +3 more
core   +1 more source

1-[3-(4-Chlorophenyl)isoquinolin-1-yl]-3,5-diethyl-1H-pyrazole

Acta Crystallographica Section E, 2010
The title compound, C22H20ClN3, is composed of a dialkyl-substituted pyrazole ring connected to an aryl-substituted isoquinoline ring system with a dihedral angle of 55.8 (1)° between the pyrazole ring and and the isoquinoline ring ...
F. Nawaz Khan, P. Manivel, K. Prabakaran, Venkatesha R. Hathwar, Seik Weng Ng   +4 more
doaj   +1 more source

Investigating isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins for ovarian cancer treatment

, 2017
Chen Chen,1,* Jie Wu,2,* Pengfei Zhu,3 Congjian Xu,1 Liangqing Yao1 1Obstetrics and Gynecology Hospital and Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, 2Department of Chemistry, Fudan University, Shanghai, 3Department of ...
Yao L, Wu J, Zhu P, Xu C, Chen C
core