Results 41 to 50 of about 24,191 (225)

Catalyst-Free Spontaneous Aza-Mannich/Lactamization Cascade Reaction: Easy Access to Polycyclic δ-Lactams

Molecules
Ring-fused azacyclic compounds are important building blocks in the synthesis of natural products and pharmaceutical agents. Herein, we report an effective and valuable one-pot approach to obtaining polycyclic fused δ-lactams from readily available 2 ...
Antonia Di Mola, Caterina Vietri, Consiglia Tedesco, Antonio Massa   +3 more
doaj   +1 more source

Synthesis of 8-Fluoro-3,4-dihydroisoquinoline and Its Transformation to 1,8-Disubstituted Tetrahydroisoquinolines

Molecules, 2018
A simple procedure for the synthesis of 8-fluoro-3,4-dihydroisoquinoline is described below, based on a directed ortho-lithiation reaction. This key intermediate was then applied in various transformations.
Csilla Hargitai, Tamás Nagy, Judit Halász, Gyula Simig, Balázs Volk   +4 more
doaj   +1 more source

Secondary Metabolites with Antifungal Activities from Mangrove Derived Fungus Monascus purpureus WMD2424

Marine Drugs, 2023
The mold Monascus, also called red yeast rice, anka, or koji, has been used as the natural food coloring agent and food additives for more than 1000 years in Asian countries. It has also been used in Chinese herbology and traditional Chinese medicine due
Ming-Der Wu, Jih-Jung Chen, Ming-Jen Cheng   +2 more
doaj   +1 more source

The Role of Hydrogen Bond Interactions in Crystal Formation of Pyrrolo-Azines Alcohols

Crystals
New secondary alcohols of type Ar-CHOH-hetaryl and MeCHOH-hetaryl, the radical hetaryl being a pyrroloazine, were investigated in solid state by X-ray single-crystal diffraction analysis, Hirshfeld analysis and DFT methods to assess their ...
Marcel Mirel Popa, Mihai Răducă, Isabela C. Man, Florea Dumitrascu   +3 more
doaj   +1 more source

Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents

Acta Pharmaceutica, 2016
As a part of ongoing studies in developing new anticancer agents, novel 1,2-dihydropyridine 4, thienopyridine 5, isoquinolines 6–20, acrylamide 21, thiazolidine 22, thiazoles 23–29 and thiophenes 33–35 bearing a biologically active quinoline nucleus were
Ghorab Mostafa M., Alsaid Mansour S., Al-Dosari Mohammed S., Ragab Fatma A., Al-Mishari Abdullah A., Almoqbil Abdulaziz N.   +5 more
doaj   +1 more source

Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy

Pharmaceutics, 2022
Nowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens.
Dorina Amariucai-Mantu, Violeta Mangalagiu, Iustinian Bejan, Aculina Aricu, Ionel I. Mangalagiu   +4 more
doaj   +1 more source

Facile Synthesis of 3-Substituted Thiazolo[2,3-α]tetrahydroisoquinolines

Molecules, 2021
It was found that 4-hydroxy-2-butenoic ester (11) could not react with 3,4-dihydro-isoquinoline (4a). Individual addition reactions of γ-mercapto-α,β-unsaturated esters (18) and -unsaturated amide (19) with 3,4-dihydroisoquinolines (4) were carried out ...
Sheng-Han Huang, Wan-Yu Huang, Guo-Lun Zhang, Te-Fang Yang   +3 more
doaj   +1 more source

Microcalorimetric study on the bacteriostatic activity of isoquinoline alkaloids

, 2007
The isoquinoline alkaloids were isolated from traditional Chinese drugs of Phellodendri Cortex, Radix Stephaniae Tetrandrae, Corydalis Yanhusuo and Corydalis Bungeana. The power-time curves of growth of E. coli at different concentrations of isoquinoline
Tan, Z.-C., Liu, X. J., Zhang, H. L., 谭志诚, Han, K. L., Sun, L. X.   +5 more
core   +1 more source

Synthesis of New β-enaminones of Isoquinolines with 5,5-dimethyl-cyclohexanedione

Molbank, 2008
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Stoyanka Nikolova, Iliyan Ivanov
doaj   +1 more source

Stereochemistry of the methylidene-bridged quinazoline-isoquinoline alkaloid 3-{[6,7-dimethoxy-1-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]methylidene}-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-9-one methanol monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2020
Two potentially bioactive fragments, namely a tricyclic quinazoline derivative with an exocyclic alkene moiety and a substituted isoquinoline, are coupled to give 3-{[6,7-dimethoxy-1-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]methylidene}-1,2,3,9-
Akmal Tojiboev, Sherzod Zhurakulov, Valentina Vinogradova, Ulli Englert, Ruimin Wang   +4 more
doaj   +1 more source