Results 51 to 60 of about 24,191 (225)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Synthesis and Pharmacological Evaluation of New 3,4-Dihydroisoquinolin Derivatives Containing Heterocycle as Potential Anticonvulsant Agents

Molecules, 2016
Two novel series of 3,4-dihydroisoquinolin with heterocycle derivatives (4a–t and 9a–e) were synthesized and evaluated for their anticonvulsant activity using maximal electroshock (MES) test and pentylenetetrazole (PTZ)-induced seizure test.
Hong-Jian Zhang, Qing-Kun Shen, Chun-Mei Jin, Zhe-Shan Quan   +3 more
doaj   +1 more source

Citronamine A, an Antiplasmodial Isoquinoline Alkaloid from the Australian Marine Sponge Citronia astra

, 2020
Citronamine A (1), an isoquinoline alkaloid containing an unprecedented pentacyclic ring system, was isolated from the Australian marine sponge Citronia astra.
Prebble, Dale W, Carroll, Anthony R, Avery, Vicky M, Holland, Darren C, Robertson, Luke P   +4 more
core   +1 more source

Biosynthesis of Isoquinoline Alkaloids [PDF]

Planta Medica, 1979
The isoquinoline alkaloids and their biosynthetic relatives include many compounds which show important physiological properties in animals: dopamine, mescaline, morphine, papaverine, and narcotine are pertinent examples. The biosynthetic routes to the members of this family start from the essential aminoacids tyrosine or phenylalanine. Decarboxylation
openaire   +2 more sources

Effect of mobile phase buffer ph on separation selectivity of some isoquinoline alkaloids in reversed-phase systems of Pressurized Planar Electrochromatography and High-Performance Thin-Layer Chromatography

Current Issues in Pharmacy and Medical Sciences, 2013
Separation of some isoquinoline alkaloids (narcotine, chelidonine, dihydrocodeine, cinchonine, berberine, cinchonidine, papaverine, apomorphine) has been investigated with pressurized planar electrochromatography (PPEC) and high-performance thin-layer ...
Ewelina Kopciał, Beata Polak, Rafał Pietraś, Paulina Mączka, Tadeusz H. Dzido   +4 more
doaj   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Synthesis of 3,4,5,6,7,8-hexahydro-1-substituted phenyl isoquinoline and 3,4,5,6,7,8-hexahydro-1-substituted benzyl isoquinoline [PDF]

, 2007
Isoquinoline derivatives are obtained from amides using AlCl3-KI in acetonitrile solvent. This cyclo dehydrating Lewis acid produced no side product and yield is above 95% isoquinoline derivative at room ...
Birendra N. Goswami, GOSWAMI, B N, BORTHAKUR , S K, Susanta Kr. Borthakur   +3 more
core   +1 more source

Cross‐Dehydrogenative Coupling Reactions With Redox‐Active Guanidine Reagents

Chemistry – A European Journal, EarlyView.
ABSTRACT Cross‐dehydrogenative coupling (CDC) reactions are attractive and environmentally friendly ways to form new C‐C and other element‐element bonds. Here, we report the first CDC reactions triggered by a redox‐active guanidine reagent. N‐phenyltetrahydroisoquinoline and derivatives with electron‐donating and withdrawing substituents at the N ...
Petra Walter, Olaf Hübner, Hans‐Jörg Himmel   +2 more
wiley   +1 more source

A Naphthalene Monoimide Meisenheimer Complex as Strong Organic Hydride Donor for Metal‐Free CO2 Reduction

Chemistry – A European Journal, EarlyView.
A Meisenheimer complex derived from two‐fold reduction and protonation of naphthalene monoamide has been identified as a strong organic hydride donor which is able to reduce CO2. ABSTRACT Selective CO2 reduction to formate is challenging due to similar thermodynamics for the reaction to other products such as carbon monoxide and molecular hydrogen ...
C. Jasslie Nielsen, Catriona C. James, Maartje C. van Rijn, Bente Reus, Bettina Baumgartner, Sonja Pullen   +5 more
wiley   +1 more source