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Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases

Pharmacological Research, 2022
Complex diseases such as neurodegenerative disorders and cancer constitute a growing public health problem due to the rising incidence and lack in effective therapies.
Erika Plazas +3 more
doaj

Photoinduced Hydrogen Evolution Catalyzed by Co(II) Complexes of N5‐Donor Ligands

Chemistry – A European Journal, Volume 31, Issue 28, May 19, 2025.
Cobalt(II) complexes of three related pentadentate ligands have been investigated as photoelectrochemical catalysts for proton reduction/hydrogen gas evolution in the presence of ruthenium, iridium, or copper‐based photosensitizers. Potential mechanisms for hydrogen evolution have been investigated by time‐resolved transient absorption spectroscopy and
Chuanshuai Li +14 more
wiley +1 more source

Lamellarin D Acts as an Inhibitor of Type I Collagen Production

ChemMedChem, Volume 20, Issue 9, May 5, 2025.
COL1A2 gene, encoding type I collagen, is a key target for pulmonary fibrosis. We established a screening system to identify small molecules that inhibit COL1A2 gene expression. Using this system, we screen a library of compounds and identify lamellarin D as a potent inhibitor of COL1A2 expression, suggesting lamellarin D is a promising new lung ...
Daisuke Okuno +19 more
wiley +1 more source

Rhodium-Catalyzed Isoquinoline Synthesis Using Vinyl Selenone as Oxidizing Acetylene Surrogate [PDF]

Inami A., Nishii Y., Hirano K., et al. Rhodium-Catalyzed Isoquinoline Synthesis Using Vinyl Selenone as Oxidizing Acetylene Surrogate. Organic Letters 25, 3206 (2023); https://doi.org/10.1021/acs.orglett.3c00826.Isoquinoline is a privileged structure in ...
Hirano, Koji +3 more
core +1 more source

A domino reaction for the synthesis of pyrrolo[2,1-a]isoquinolines from 2-aryl-pyrrolidines and alkynes promoted by a four-component catalytic system under aerobic conditions. [PDF]