Results 41 to 50 of about 16,127 (272)

Intramolecular cyclization of b,b-difluorostyrenes bearing an iminomethyl or a diazenyl group at the ortho position: synthesis of 3-fluorinated isoquinoline and cinnoline derivatives [PDF]

, 2007
journal ...
ICHIKAWA Junji, Kuroki Hiroyuki, Mihara Jun, Nadano Ryo, Wada Yukinori   +4 more
core   +1 more source

Rapid Methylation of Aryl Bromides Using Air‐Stable DABCO‐Bis(Trimethylaluminum) via Nickel Metallaphotoredox Catalysis

Angewandte Chemie, EarlyView.
Herein, we report the use of bis(trimethylaluminum)‐1,4‐diazabicyclo[2.2.2]octane (DABAl‐Me3) as practical source of radicals for the introduction of valuable methyl groups to aryl bromides via a Nickel/metallaphotocatalytic cross coupling strategy.
Jonas Djossou, Andrea Aloia, Luca Capaldo, Demi D. Snabilié, Morgan Regnier, Jasper H.A. Schuurmans, Antonio Monopoli, Bas de Bruin, Timothy Noël   +8 more
wiley   +2 more sources

Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]

, 2013
Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Amann, Kerstin, Babelova, Andrea, Brandes, Ralf Peter Louis, Daniel, Christoph, Fork, Christian, Jansen, Felix, Jung, Oliver, Löhn, Matthias, Pavenstädt, Hermann, Plettenburg, Oliver, Ruetten, Hartmut, Sander, Kerstin, Schäfer, Liliana, Stark, Holger   +13 more
core   +4 more sources

Synthesis and properties of Thieno[3,2-f]isoquinolines and Benzothieno[3,2-f]isoquinolines [PDF]

, 2022
A variety of thieno[3,2-f]isoquinolines were prepared by combination of Pd catalysed cross-coupling reactions with Brønsted acid mediated cycloisomerisations. The reactions tolerate various functional groups and proceed with high selectivity. In addition,
Blanco Ponce, Marian, Ehlers, Peter, Hermosilla Espinosa, Robinson, Langer, Peter, Mangione, Maria Ines, Torres Rodriguez, Eugenio   +5 more
core   +1 more source

2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19 [PDF]

, 2016
We demonstrate a designed scaffold-hop approach to the discovery of 2,8-disubstituted-1,6-naphthyridine- and 4,6-disubstituted-isoquinoline-based dual CDK8/19 ligands.
Blagg, Julian, Burke, Rosemary, Busch, Michael, Clarke, Paul A., Czodrowski, Paul, Eccles, Suzanne A., Esdar, Christina, Honey, Mark A., Mallinger, Aurélie, Musil, Djordje, Poeschke, Oliver, Raynaud, Florence I., Rink, Christian, Rohdich, Felix, Schiemann, Kai, Schneider, Richard, Schwartz, Daniel, Sejberg, Jimmy, Stubbs, Mark, Urbahns, Klaus, Wienke, Dirk, Workman, Paul   +21 more
core   +5 more sources

Discovery of thiazolo [5,4-c] isoquinoline based compounds as acetylcholinesterase inhibitors through computational target prediction, molecular docking and bioassay [PDF]

, 2023
We thank Nathalie Reichmann and Leendert Hamoen (University of Amsterdam) for critical reading of the manuscript, Ana Velic (Proteome Center Tübingen) for help with proteome analysis and Mike VanNieuwenhze (Indiana University) for the generous gift of ...
Costa, Letícia D., Faustino, Maria Amparo F., Pereira, Florbela, Pinto, Diana C. G. A., Silva, Artur M. S., Silva, Carlos F. M., Tomé, Augusto C.   +6 more
core   +1 more source

Dopaminergic isoquinolines with hexahydrocyclopenta[ ij ]-isoquinolines as D 2 -like selective ligands

European Journal of Medicinal Chemistry, 2016
Dopamine receptors (DR) ligands are potential drug candidates for treating neurological disorders including schizophrenia or Parkinson's disease. Three series of isoquinolines: (E)-1-styryl-1,2,3,4-tetrahydroisoquinolines (series 1), 7-phenyl-1,2,3,7,8,8a-hexahydrocyclopenta[ij]-IQs (HCPIQs) (series 2) and (E)-1-(prop-1-en-1-yl)-1,2,3,4 ...
Párraga, Javier, Andujar, Sebastian Antonio, Rojas, Sebastian, Gutierrez, Lucas Joel, El Aouad, Noureddine, Sanz, M. Jesús, Enriz, Ricardo Daniel, Cabedo, Nuria, Cortes, Diego   +8 more
openaire   +6 more sources

Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions

Nature Communications, 2019
Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral ...
Qian Xiong, Shunxi Dong, Yushuang Chen, Xiaohua Liu, Xiaoming Feng   +4 more
doaj   +1 more source

Synthesis of pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines via three-component [3 + 2] cycloaddition followed by one-pot N-allylation and intramolecular Heck reactions

Beilstein Journal of Organic Chemistry, 2020
Two kinds of [3 + 2] cycloaddition intermediates generated from the three-component reactions of 2-bromobenzaldehydes and maleimides with amino esters or amino acids were used for a one-pot N-allylation and intramolecular Heck reactions to form ...
Xiaoming Ma, Suzhi Meng, Xiaofeng Zhang, Qiang Zhang, Shenghu Yan, Yue Zhang, Wei Zhang   +6 more
doaj   +1 more source

Benzo[de]naphtho[1,8-gh]quinolines: synthesis, photophysical studies and nitro explosives detection

Chimica Techno Acta, 2021
A rational synthetic approach to substituted naphtho[1,8-gh]quinolines using intramolecular cyclization in the presence of potassium in the series of (naphthalen-1-yl)isoquinolines is described. The photophysical properties of the obtained compounds were
Igor L. Nikonov, Igor A. Khalymbadzha, Leila К. Sadieva, Maria I. Savchuk, Ekaterina S. Starnovskaya, Dmitry S. Kopchuk, Igor S. Коvalev, Grigory А. Kim, Oleg N. Chupakhin   +8 more
doaj   +1 more source