Results 41 to 50 of about 17,105 (265)
Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]
, 2013 Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Amann, Kerstin +13 more
core +4 more sources
Stable BF2 Boracycles as Versatile Reagents for Selective Ortho C–H Functionalization
Angewandte Chemie, EarlyView.We report a robust, metal‐free and scalable synthesis of stable BF2 boracycles via directed ortho CH borylation, delivering isolable, shelf‐stable reagents without chromatographic purification. These BF2 boracycles exhibit unique and tunable reactivity, enabling highly selective ipso‐functionalization across a broad range of transformations.
Ganesh H. Shinde +11 more
wiley +2 more sources
Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]isoquinolines
Molecules, 2022 A new series of pyrazolo[3,4-g]isoquinoline derivatives, diversely substituted at the 4- or 8-position, were synthesized. The results of the kinase inhibitory potency study demonstrated that the introduction of a bromine atom at the 8-position was ...
Mathilde Defois +8 more
doaj +1 more source
Angewandte Chemie, EarlyView.An iron‐catalyzed protocol for the cascade cyclization of N‐aryl and N‐benzoyl acrylamides promoted by methane and other gaseous alkanes is reported. The current protocol provides an efficient platform for the conversion of feedstock gaseous alkanes into complex and medicinally relevant N‐heterocycles.
Akshay M. Nair +3 more
wiley +2 more sources
Beilstein Journal of Organic Chemistry, 2018 Highly-substituted isoquinolines are important scaffolds in syntheses of natural products and in drug development and hence, effective synthetic approaches are required.
Benedikt C. Melzer +2 more
doaj +1 more source
Organocatalytic Kinetic Resolution of Ferroceno[c]isoquinolines through Asymmetric Transfer Hydrogenation [PDF]
JACS AuYan-Jiang Yu +5 more
doaj +2 more sources
Hypecoum spp.—Chemistry and Biological Activity of Alkaloids
Diversity, 2023 Genus Hypecoum Tourn. ex L. belongs to the poppy family Papaveraceae and comprises about 19 species occurring in Europe, Northern Africa and Asia.
Nadezhda Kostova, Tsvetelina Doncheva
doaj +1 more source
Tertiary Alcohols as Radical Precursors for the Introduction of Tertiary Substituents into Heteroarenes [PDF]
, 2019 Despite many recent advances in the radical alkylation of electron-deficient heteroarenes since the seminal reports by Minisci and co-workers, methods for the direct incorporation of tertiary alkyl substituents into nitrogen heteroarenes are limited ...
Fishman, DA +3 more
core +2 more sources
Asymmetric addition of chiral boron-ate complexes to cyclic iminium ions [PDF]
, 2014 Boron-ate complexes derived from enantioenriched secondary benzylic boronic esters and aryl lithiums have been reacted with quinolinium, pyridinium and dihydroisoquinolinium salts to give enantioenriched heterocyclic structures with very high ...
Aggarwal, Varinder K. +4 more
core +2 more sources
Molecules, 2002 Different types of novel 1,2-disubstituted 1,2-dihydro isoquinolines were synthesized by addition reactions of organolithium, alcoholates and borohydride reagents with various isoquinolinium salts.
Jean Pierre Bazureau +1 more
doaj +1 more source