Results 21 to 30 of about 4,349 (172)

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan, Yunguang Qiu, Shreyans Sethi, Diwakar Mahajan, Hongyang Li, Yuxin Yang, Elif Eyigoz, Aldo Guzmán‐Sáenz, Daniel E. Platt, Timothy H. Rumbell, Kenney Ng, Sanjoy Dey, Myson Burch, Bum Chul Kwon, Pablo Meyer, Feixiong Cheng, Jianying Hu, Joseph A. Morrone   +17 more
wiley   +1 more source

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source

THE CHOICE OF NITRATE THERAPY IN PATIENTS WITH STABLE ANGINA: COMPARATIVE STUDY OF ISOSORBIDE DINITRATE (IN USUAL TABLETS) WITH ISOSORBIDE-5-MONONITRATE (IN VARIOUS PRESENTATIONS)

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study efficacy and tolerability of isosorbide-5-mononitrate (IMN) in various presentations in comparison with isosorbide dinitrate (IDN) in usual tablets in patients with stable angina.Material and Methods.
V. A. Egoro, E. V. Shilova, S. Y. Martsevich   +2 more
doaj   +1 more source

Safety and Efficacy of Endoluminal Vasodilators on the Prevention of Vasospasm in Deep Inferior Epigastric Perforator Flap Breast Reconstruction: A Prospective Controlled Study

Journal of Reconstructive Microsurgery Open, 2016
Background The spasm of the internal mammary artery (IMA) and inferior epigastric pedicle (IEP) is critical in deep inferior epigastric perforator (DIEP) flap breast reconstruction.
Barbara Hersant, Romain Bosc, Mounia SidAhmed-Mezi, Mathieu Kerneis, Jean-Paul Meningaud   +4 more
doaj   +1 more source

Drug-Induced Hemolysis in G6PD Deficiency: an Unusual Presentation of a Common Clinical Condition

Acta Medica, 2020
Glucose-6-phosphate dehydrogenase (G6PD) deficiency can present a diagnostic dilemma owing to the varying degrees of disease severity and the wide range of precipitating factors.
Anudeep Padakanti, Ashok Shenoy, Ashwin Kamath, Mahabala Chakrapani   +3 more
doaj   +1 more source

Executive Summary of the 2024 Philippine Clinical Practice Guidelines on the Diagnosis and Management of Acute Severe Blood Pressure Elevation

The Journal of Clinical Hypertension, Volume 28, Issue 2, February 2026.
ABSTRACT A recent survey in the Philippines, PRESYON‐4, showed increasing prevalence of hypertension from 22% in the 1990s to 37% in 2021, of which only 52% were aware of their diagnosis. While rates of treatment and adherence were 68% and 86%, respectively, the rate of BP control was low at 37%. Furthermore, there remained a high degree of unawareness
Deborah Ignacia D. Ona, Felix Eduardo Punzalan, Raymond V. Oliva, Ma. Sergia Fatima Sucaldito, Noel Espallardo, Richard Santos, Hannah Almenario, Karl Murillo, Valentin Dones III, Elmer Jasper Llanes, Lourdes Ella Santos, Maria Cristina San Jose, Alyssa Samantha Fusingan‐Peralta, Rommel Bataclan, Maria Katrina Mata, Pauline Convocar, Aurelia Leus, Gilbert Vilela   +17 more
wiley   +1 more source

Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers

Drug Design, Development and Therapy, 2014
Maria Vittoria Cossu,1 Dario Cattaneo,1 Serena Fucile,1 Paolo Pellegrino,1 Sara Baldelli,1 Valeria Cozzi,1 Amedeo Capetti,2 Emilio Clementi1,3 1Unit of Clinical Pharmacology, Consiglio Nazionale delle Ricerche Institute of Neuroscience, Department of ...
Cossu MV, Cattaneo D, Fucile S, Pellegrino P, Baldelli S, Cozzi V, Capetti A, Clementi E   +7 more
doaj  

Lithium Nitrate Effects for Lithium‐Based Chemical Batteries: A Review

Carbon Energy, Volume 8, Issue 1, January 2026.
Lithium nitrate (LiNO3) has been widely used to address uneven Li plating/stripping and stabilize the Li/electrolyte interface, and to date, many strategies on how to use nitrates have been explored. This review focuses attention on the effects of LiNO3 in lithium‐based batteries, aiming to provide scientific guidance for the optimization of electrode ...
Xianshu Wang, Junru Wu, Huirong Wang, Xiangshao Yin, Zhuo Zhou, Yuanyuan Huang, Yelong Zhang, Weishan Li, Baohua Li   +8 more
wiley   +1 more source

Involvement of Guanylate Cyclase and K+ Channels in Relaxation Evoked by Ferulate Nitrate in Rat Aorta Artery

Journal of Pharmacological Sciences, 2012
Vasorelaxant properties of N-2-(ferulamidoethyl)-nitrate (ferulate nitrate, FLNT), a newly synthesized nitrate, were compared with those of isosorbide dinitrate, nicorandil, nitroglycerin, and 8-bromoguanosine 3,5-cyclic monophosphate (8-Br-cGMP) in rat ...
Zhan-Qing Wang, Jing-Feng Xu, Jin-Ping Wang, Wei-Juan Zhao, Ming Zeng   +4 more
doaj   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source