Results 41 to 50 of about 8,875 (220)

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers

Drug Design, Development and Therapy, 2014
Maria Vittoria Cossu,1 Dario Cattaneo,1 Serena Fucile,1 Paolo Pellegrino,1 Sara Baldelli,1 Valeria Cozzi,1 Amedeo Capetti,2 Emilio Clementi1,3 1Unit of Clinical Pharmacology, Consiglio Nazionale delle Ricerche Institute of Neuroscience, Department of ...
Cossu MV, Cattaneo D, Fucile S, Pellegrino P, Baldelli S, Cozzi V, Capetti A, Clementi E   +7 more
doaj  

Drug-Induced Hemolysis in G6PD Deficiency: an Unusual Presentation of a Common Clinical Condition

Acta Medica, 2020
Glucose-6-phosphate dehydrogenase (G6PD) deficiency can present a diagnostic dilemma owing to the varying degrees of disease severity and the wide range of precipitating factors.
Anudeep Padakanti, Ashok Shenoy, Ashwin Kamath, Mahabala Chakrapani   +3 more
doaj   +1 more source

Multisystem Sarcoidosis Presenting With Hypercalcemia, Lytic Bone Lesion, and Mesenteric Panniculitis in Chronic Kidney Disease

Clinical Case Reports, Volume 14, Issue 4, April 2026.
The clinical photograph shows bilateral leg swelling with right‐sided predominance and cutaneous changes. CT images (A–C) demonstrate abdominal and retroperitoneal lymphadenopathy, and image D shows a hypodense lytic spinal lesion, suggesting multifocal disease involving the abdomen, retroperitoneum, and spine.
Aishwarya Holi, Karuna Rayamajhi, Satya Rijal, Niket Shah, Aaron Sousa, Gina Chacon Osorio   +5 more
wiley   +1 more source

Involvement of Guanylate Cyclase and K+ Channels in Relaxation Evoked by Ferulate Nitrate in Rat Aorta Artery

Journal of Pharmacological Sciences, 2012
Vasorelaxant properties of N-2-(ferulamidoethyl)-nitrate (ferulate nitrate, FLNT), a newly synthesized nitrate, were compared with those of isosorbide dinitrate, nicorandil, nitroglycerin, and 8-bromoguanosine 3,5-cyclic monophosphate (8-Br-cGMP) in rat ...
Zhan-Qing Wang, Jing-Feng Xu, Jin-Ping Wang, Wei-Juan Zhao, Ming Zeng   +4 more
doaj   +1 more source

A Double-Blind Randomized Trial Comparing the Effectiveness and Safety of Nifedipine and Isosorbide Dinitrate in Chronic Anal Fissure [PDF]

, 2015
Background: Chronic anal fissure is a common disease that is accompanied with pain and bleeding during defecation. Various surgical and non-surgical methods have been offered for the treatment of this condition.
Khaledifar, Borzoo., Mobasheri, Mahmoud., Yousefi Ahmad Mahmoudi, Mehran.   +2 more
core   +1 more source

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan, Yunguang Qiu, Shreyans Sethi, Diwakar Mahajan, Hongyang Li, Yuxin Yang, Elif Eyigoz, Aldo Guzmán‐Sáenz, Daniel E. Platt, Timothy H. Rumbell, Kenney Ng, Sanjoy Dey, Myson Burch, Bum Chul Kwon, Pablo Meyer, Feixiong Cheng, Jianying Hu, Joseph A. Morrone   +17 more
wiley   +1 more source

Impairment by Hypoxia or Hypoxia/Reoxygenation of Nitric Oxide–Mediated Relaxation in Isolated Monkey Coronary Artery: the Role of Intracellular Superoxide

Journal of Pharmacological Sciences, 2011
.: To investigate the effect of hypoxia or hypoxia/reoxygenation on vascular smooth muscle function, mechanical response of monkey coronary artery without endothelium was studied under normoxia, hypoxia, and hypoxia/reoxygenation.
Masashi Tawa, Kohei Yamamizu, Ayman Geddawy, Takashi Shimosato, Takeshi Imamura, Kazuhide Ayajiki, Tomio Okamura   +6 more
doaj   +1 more source

Response of conductance and resistance coronary vessels to scalar concentrations of acetylcholine: Assessment with quantitative angiography and intracoronary Doppler echography in 29 patients with coronary artery disease [PDF]

, 1994
Abnormal vasoreactivity of the large conductance arteries has been observed in the presence of impaired endothelial function. More recently, experimental and clinical reports have shown that in early coronary atherosclerosis the impairment of the ...
Feyter, P.J. (Pim) de, Gil, R. (Robert), Jaegere, P.P.T. (Peter) de, Mario, C. (Carlo) di, Serruys, P.W.J.C. (Patrick), Strikwerda, S. (Sipke)   +5 more
core   +1 more source

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source